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Ting-Li Han
University of Auckland
40Publications
9H-index
216Citations
Publications 40
Newest
Published on Apr 8, 2019
Ting-Li Han9
Estimated H-index: 9
(CQMU: Chongqing Medical University),
Richard D. Cannon36
Estimated H-index: 36
(University of Otago)
+ 1 AuthorsSilas G. Villas-Bôas2
Estimated H-index: 2
(University of Auckland)
There are two glutamate dehydrogenases in the pathogenic fungus Candida albicans. One is an NAD+-dependent glutamate dehydrogenase (GDH2) and the other is an NADPH-dependent glutamate dehydrogenase (GDH3). These two enzymes are part of the nitrogen and nicotinate/nicotinamide metabolic pathways, which have been identified in our previous studies as potentially playing an important role in C. albicans morphogenesis. In this study, we created single gene knockout mutants of both dehydrogenases in ...
Published on Sep 6, 2018in Journal of Maternal-fetal & Neonatal Medicine1.57
Jinjin Li1
Estimated H-index: 1
(CQMU: Chongqing Medical University),
Chao Tong8
Estimated H-index: 8
(CQMU: Chongqing Medical University)
+ 10 AuthorsShunping Gui (CQMU: Chongqing Medical University)
AbstractObjective: Oxidative stress plays a significant role in the pathogenesis of preeclampsia (PE), by inducing trophoblast cell death and consequent placental dysfunction. Quiescin sulfhydryl oxidase 1 (QSOX1) is upregulated in many types of cancer cells; it promotes disulfide bond formation as well as hydrogen peroxide (H2O2) production. The aims of present study are to investigate the expression pattern of QSOX1 in placentae of pregnancies complicated by PE and the role of QSOX1 in the reg...
Published on Aug 1, 2019in Experimental Cell Research3.33
Andi Wang , Ting-Li Han9
Estimated H-index: 9
+ 5 AuthorsHua Zhang9
Estimated H-index: 9
Abstract Maternal obesity is associated with adverse effects on the health of offsprings. Consumption of a high-carbohydrate (HC) diet has been found to promote abnormal fatty acid metabolism in adipose tissue. Therefore, we hypothesised that maternal obesity combined with an offspring HC diet would alter the fatty acid metabolism of adipose tissue and subsequently contribute to offspring obesity. Lepr db/+ mice were used to model pre-pregnancy maternal obesity and the C57BL/6 wildtype were used...
Published on May 1, 2019in Experimental Cell Research3.33
Yunlin Chen1
Estimated H-index: 1
(CQMU: Chongqing Medical University),
Jinqi Fan (CQMU: Chongqing Medical University)+ 5 AuthorsYin Yuehui13
Estimated H-index: 13
(CQMU: Chongqing Medical University)
Abstract Background Cell metabolic pathways are highly conserved among species and change rapidly in response to drug stimulation. Therefore, we explore the effects of angiotensin-(1-7) in a primary cell model of cardiac fibrosis established in angiotensin II-stimulated cardiac fibroblasts via metabolomics analysis and further clarify the potential protective mechanism of angiotensin-(1-7). Methods and Results After exposing cardiac fibroblasts to angiotensin II and/or angiotensin-(1-7), 172 met...
Published on Apr 1, 2019in GigaScience4.69
Kang Kang2
Estimated H-index: 2
(Leibniz Association),
Basti Bergdahl2
Estimated H-index: 2
(DTU: Technical University of Denmark)
+ 7 AuthorsGianni Panagiotou21
Estimated H-index: 21
(Leibniz Association)
G.P. would like to thank Deutsche Forschungsgemeinschaft (DFG) CRC/Transregio 124 “Pathogenic fungi and their human host: Networks of interaction,” subproject B5. B.B., L.D., M.J.H., and J.F. thank the Novo Nordisk Foundation for financial support.
Published on Feb 1, 2019in Environmental Toxicology2.65
Ting-Ting Mo1
Estimated H-index: 1
(CQMU: Chongqing Medical University),
Hua Dai (CDC: Centers for Disease Control and Prevention)+ 21 AuthorsChengzhi Chen4
Estimated H-index: 4
(CQMU: Chongqing Medical University)
Published on Dec 18, 2018in BioMed Research International2.20
Thibaut D. J. Delplancke (CQMU: Chongqing Medical University), Yue Wu (CQMU: Chongqing Medical University)+ 4 AuthorsPhilip N. Baker26
Estimated H-index: 26
(University of Leicester)
In recent years, the study of metabolomics has begun to receive increasing international attention, especially as it pertains to medical research. This is due in part to the potential for discovery of new biomarkers in the metabolome and to a new understanding of the “exposome”, which refers to the endogenous and exogenous compounds that reflect external exposures. Consequently, metabolomics research into pregnancy-related issues has increased. Biomarkers discovered through metabolomics may shed...
Published on Dec 1, 2018in Scientific Reports4.01
Thibaut Delplancke3
Estimated H-index: 3
(CQMU: Chongqing Medical University),
Jamie V. de Seymour4
Estimated H-index: 4
(University of Auckland)
+ 5 AuthorsPhilip N. Baker16
Estimated H-index: 16
(CQMU: Chongqing Medical University)
The hair metabolome has been recognized as a valuable source of information in pregnancy research, as it provides stable metabolite information that could assist with studying biomarkers or metabolic mechanisms of pregnancy and its complications. We tested the hypothesis that hair segments could be used to reflect a metabolite profile containing information from both endogenous and exogenous compounds accumulated during the nine months of pregnancy. Segments of hair samples corresponding to the ...
Published on Dec 1, 2018in Scientific Reports4.01
Beatrix Jones5
Estimated H-index: 5
(University of Auckland),
Ting-Li Han9
Estimated H-index: 9
(CQMU: Chongqing Medical University)
+ 5 AuthorsPhilip N. Baker26
Estimated H-index: 26
(CQMU: Chongqing Medical University)
The fetus undergoes a crucial period of neurodevelopment in utero. The maternal hair metabolome provides an integrated record of the metabolic state of the mother prior to, and during pregnancy. We investigated whether variation in the maternal hair metabolome was associated with neurodevelopmental differences across infants. Maternal hair samples and infant neurocognitive assessments (using the Bayley III Scales of Infant Development at 24 months) were obtained for 373 infant-mother dyads betwe...
Published on Dec 1, 2018in Scientific Reports4.01
Lianlian Wang5
Estimated H-index: 5
,
Ting-Li Han9
Estimated H-index: 9
+ 10 AuthorsRichard Saffery44
Estimated H-index: 44
(University of Melbourne)
The selective intrauterine growth restriction (sIUGR) of monochorionic diamniotic (MCDC) twins causes phenotypic growth discordance, which is correlated with metabolomic pertubations. A global, untargeted identification of the metabolic fingerprint may help elucidate the etiology of sIUGR. Umbilical cord blood and placentas collected from 15 pairs of sIUGR monochorionic twins, 24 pairs of uncomplicated twins, and 14 singletons diagnosed with intrauterine growth restriction (IUGR) were subjected ...
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