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Quercetin conjugated with superparamagnetic iron oxide nanoparticles improves learning and memory better than free quercetin via interacting with proteins involved in LTP

Published on May 3, 2019in Scientific Reports 4.01
· DOI :10.1038/s41598-019-43345-w
Elnaz Amanzadeh1
Estimated H-index: 1
(UI: University of Isfahan),
Abolghasem Esmaeili8
Estimated H-index: 8
(UI: University of Isfahan)
+ 3 AuthorsSiamak Beheshti6
Estimated H-index: 6
(UI: University of Isfahan)
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Abstract
Biomedical application of quercetin (QT) as an effective flavonoid has limitations due to its low bioavailability. Superparamagnetic iron oxide nanoparticle (SPION) is a novel drug delivery system that enhances the bioavailability of quercetin. The effect of short time usage of quercetin on learning and memory function and its signaling pathways in the healthy rat is not well understood. The aim of this study was to investigate the effect of free quercetin and in conjugation with SPION on learning and memory in healthy rats and to find quercetin target proteins involved in learning and memory using Morris water maze (MWM) and computational methods respectively. Results of MWM show an improvement in learning and memory of rats treated with either quercetin or QT-SPION. Better learning and memory functions using QT-SPION reveal increased bioavailability of quercetin. Comparative molecular docking studies show the better binding affinity of quercetin to RSK2, MSK1, CytC, Cdc42, Apaf1, FADD, CRK proteins. Quercetin in comparison to specific inhibitors of each protein also demonstrates a better QT binding affinity. This suggests that quercetin binds to proteins leading to prevent neural cell apoptosis and improves learning and memory. Therefore, SPIONs could increase the bioavailability of quercetin and by this way improve learning and memory.
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References120
Newest
Published on Feb 1, 2019in Toxicology in Vitro 3.07
Maryam Aliakbari1
Estimated H-index: 1
(UI: University of Isfahan),
Elham Mohammadian1
Estimated H-index: 1
(UI: University of Isfahan)
+ 1 AuthorsZari Pahlevanneshan5
Estimated H-index: 5
(UI: University of Isfahan)
Abstract Polyvinylpyrrolidone superparamagnetic iron oxide nanoparticles (PVP-SPIONs) have unique properties. Due to these characteristics, PVP-SPIONs have been used in several medical applications such as magnetic resonance imaging (MRI) contrast agent or drug delivery system. However, a more comprehensive understanding of the environmental safety of PVP-SPIONs is vital for consumption of these nanomaterials. In this study, we describe the effects of PVP-SPIONs on cell viability of the BT-474 h...
Published on Jan 8, 2019in Nucleic Acids Research 11.15
Sunghwan Kim15
Estimated H-index: 15
(NIH: National Institutes of Health),
Jie Chen7
Estimated H-index: 7
(NIH: National Institutes of Health)
+ 10 AuthorsBo Yu5
Estimated H-index: 5
(NIH: National Institutes of Health)
Published on Jan 1, 2019in Carbohydrate Polymers 6.04
Yuzhi Mu4
Estimated H-index: 4
(Ocean University of China),
Yangmu Fu2
Estimated H-index: 2
(Chinese PLA General Hospital)
+ 8 AuthorsChao Feng16
Estimated H-index: 16
(Ocean University of China)
Abstract In this study, quercetin-chitosan conjugate (QT-CS) was synthesized for oral delivery of doxorubicin (DOX) to improve its oral bioavailability by increasing its water solubility, opening tight junction and bypassing the P-glycoprotein (P-gp). The prepared QT-CS self-assembled into micelles which could encapsulate DOX with high encapsulation rate, small particle size (136.9 nm) and strong zeta potential (+16.2 mV). QT-CS-DOX micelles displayed sustained-release profile in gastrointestina...
Published on Dec 1, 2018in Chemosphere 5.11
Minjia Zhang2
Estimated H-index: 2
(PKU: Peking University),
Wei Liu2
Estimated H-index: 2
(PKU: Peking University)
+ 3 AuthorsYajun Xu2
Estimated H-index: 2
(PKU: Peking University)
Abstract Epidemiological studies show that maternal exposure to PM 2.5 affects the neurodevelopment of the offspring, especially the neurocognitive function. However, no relevant experimental researches have been published on toxic mechanism and diet intervention. We evaluated the effects of exposure to different doses of PM 2.5 on the behavioral development of offspring via a PM 2.5 exposure model established by intratracheal instillation, explored its mechanism and the protective effects of qu...
Published on Dec 1, 2018in Food Research International 3.58
Xing Chen8
Estimated H-index: 8
(NCU: Nanchang University),
D. Julian McClements108
Estimated H-index: 108
(UMass: University of Massachusetts Amherst)
+ 6 AuthorsChengmei Liu27
Estimated H-index: 27
(NCU: Nanchang University)
Abstract Emulsion-based excipient foods were developed to improve the bioaccessibility of an important hydrophobic nutraceutical: quercetin. Protein-stabilized oil-in-water excipient emulsions were prepared using sodium caseinate, whey protein isolate, or soy protein isolate as an emulsifier. These emulsions were then mixed with powdered quercetin and heated to simulate a cooking process. The excipient emulsions had relatively small droplet sizes ( d
Published on Dec 1, 2018in BMC Clinical Pharmacology
Rezvan Enteshari Najafabadi1
Estimated H-index: 1
(Shiraz University),
Nasrin Kazemipour7
Estimated H-index: 7
(Shiraz University)
+ 2 AuthorsSaeed Nazifi18
Estimated H-index: 18
(Shiraz University)
Background Quercetin (QT) as a bioactive flavonoid has a potential therapeutic activity for numerous neuronal injuries and neurodegenerative diseases. However, the low absorption rate of QT, especially through the blood-brain barrier, restricts its bioactivity in the body. The current research took the advantage of superparamagnetic iron oxide nanoparticles (SPIONs) to enhance the bioavailability of quercetin.
Published on Nov 1, 2018in Comparative Haematology International
Nasrin Kazemipour7
Estimated H-index: 7
(Shiraz University),
Saeed Nazifi18
Estimated H-index: 18
(Shiraz University)
+ 3 AuthorsAbolghasem Esmaeili8
Estimated H-index: 8
(UI: University of Isfahan)
The pharmaceutical use of quercetin is limited due to the problems such as low solubility, bioavailability, permeability, and instability. High doses of quercetin show toxic effects in clinical and experimental studies. Therefore, a method is needed to overcome these problems without the use of toxic doses. Iron oxide nanoparticles can be used as a drug delivery system. Biocompatible polymers such as dextran are used to cover nanoparticles to increase the stability of nanoparticles. Besides thei...
Published on Oct 1, 2018in Colloids and Surfaces B: Biointerfaces 3.97
Ait Mehdi Yamina1
Estimated H-index: 1
(CPU: China Pharmaceutical University),
Meriem Fizir3
Estimated H-index: 3
(CPU: China Pharmaceutical University)
+ 2 AuthorsPierre Dramou9
Estimated H-index: 9
(CPU: China Pharmaceutical University)
Abstract With the intent of enhancing the loading capacity and controlled the release of a low-water soluble drug (quercetin), 6 ar ms (Poly-Ethylene-Glycol)-amine was grafted in the external surface of halloysite nanotubes. The grafted halloysite nanotubes (HNTs-g-PEG) were decorated with carbon quantum dots for additive fluorescents properties. Conjointly, biotin was conjugated to PEG’s free amine groups for precise targeting of tumor tissue and higher cellular uptake. The obtained nanoparticl...
Published on Aug 1, 2018in Carbohydrate Polymers 6.04
Anu Singh4
Estimated H-index: 4
,
Piyush K. Dutta14
Estimated H-index: 14
+ 2 AuthorsAmbak Kumar Rai6
Estimated H-index: 6
(MNNIT: Motilal Nehru National Institute of Technology Allahabad)
Abstract In the present study, we have synthesized chitin-glucan-aldehyde-quercetin (chi-glu-ald-que) conjugate via condensation reaction. Synthesis of chitin-glucan-aldehyde (chi-glu-ald) complex was facilitated by the oxidation of chitin-glucan (chi-glu) complex. Formation of conjugate was confirmed by Proton nuclear magnetic resonance spectroscopy ( 1 H NMR) and Fourier-transform infrared spectroscopy (FT-IR). Morphological studies showed that after grafting of quercetin, several changes on s...
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Published in Toxicology Letters 3.50
Fei Ding (Chang'an University), Wei Peng (Ha Tai: Xiamen University)+ -3 AuthorsBing-Qi Liu (Qingdao Agricultural University)
Abstract Organophosphates are chemical pollutants that are existed widely in the environment, but the reactions of these agents with blood proteins are still not fully clarified. The current story was to analyze the static and dynamic interactions between human serum albumin (HSA) and phenthoate and then uncover the impact of the conjugations on the acetylcholinesterase (AChE) activity at the microscopic scale. Experimental results revealed clearly that the bioconjugate of the HSA-phenthoate was...