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Scientific Reports
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Papers 95285
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Published on 2019in Scientific Reports4.01
Kazuko Sakai25
Estimated H-index: 25
(Kindai University),
Masayuki Takeda26
Estimated H-index: 26
(Kindai University)
+ 7 AuthorsHidetoshi Hayashi21
Estimated H-index: 21
(Kindai University)
Medical oncologists are challenged to personalize medicine with scientific evidence, drug approvals, and treatment guidelines based on sequencing of clinical samples using next generation sequencer (NGS). Knowledge-based curation systems have the potential to help address this challenge. We report here the results of examining the level of evidence regarding treatment approval and clinical trials between recommendations made by Watson for Genomics (WfG), QIAGEN Clinical Insight Interpret (QCII),...
Published on 2019in Scientific Reports4.01
S. Viji Chandran4
Estimated H-index: 4
,
M. Vairamani12
Estimated H-index: 12
,
N. Selvamurugan40
Estimated H-index: 40
Non-availability of an ideal alternative for autografts in treating critical-size bone defects is a major challenge in orthopedics. Phytocompounds have been proven to enhance osteogenesis via various osteogenic signaling pathways, but its decreased bioavailability and increased renal clearance limit its application. In this study, we designed a biocomposite scaffold comprising gelatin (Gel) and nanohydroxyapatite (nHAp) incorporated with diosmin (DM) and we investigated its bone forming potentia...
Published on Dec 1, 2019in Scientific Reports4.01
This paper proposes an optimized implementation of the double-exposure method with emphasis on the uniformity and minimization of the residual phase imperfections in cross-referenced holographic microscopy (CRHM). The quantitative phase images are restored from single-shot cross-referenced holograms, which are separated in the Fourier space and processed to eliminate effects caused by imperfections of the optical path and sample background. CRHM is implemented in a microscope configuration suppl...
Published on Dec 1, 2019in Scientific Reports4.01
Alexandra Boginya (BIU: Bar-Ilan University), Rajesh Detroja (BIU: Bar-Ilan University)+ 2 AuthorsItay Onn11
Estimated H-index: 11
(BIU: Bar-Ilan University)
Chd1 is a chromatin remodeler that is involved in nucleosome positioning and transcription. Deletion of CHD1 is a frequent event in prostate cancer. The Structural Maintenance of Chromosome (SMC) complex cohesin mediates long-range chromatin interactions and is involved in maintaining genome stability. We provide new evidence that Chd1 is a regulator of cohesin. In the yeast S. cerevisiae, Chd1 is not essential for viability. We show that deletion of the gene leads to a defect in sister chromati...
Published on Dec 1, 2019in Scientific Reports4.01
Darpan Malhotra1
Estimated H-index: 1
(U of A: University of Alberta),
Sampath K. Loganathan8
Estimated H-index: 8
(U of A: University of Alberta)
+ 2 AuthorsJoseph R. Casey37
Estimated H-index: 37
(U of A: University of Alberta)
Two blinding corneal dystrophies, pediatric-onset congenital hereditary endothelial dystrophy (CHED) and some cases of late-onset Fuchs endothelial corneal dystrophy (FECD), are caused by SLC4A11 mutations. Three N-terminal SLC4A11 variants: v1, v2 and v3 are expressed in humans. We set out to determine which of these transcripts and what translated products, are present in corneal endothelium as these would be most relevant for CHED and FECD studies. Reverse transcription PCR (RT-PCR) and quant...
Published on Jul 18, 2019in Scientific Reports4.01
Stefano Alivernini16
Estimated H-index: 16
(UCSC: Catholic University of the Sacred Heart),
Barbara Tolusso22
Estimated H-index: 22
+ 8 AuthorsGianfranco Ferraccioli57
Estimated H-index: 57
(UCSC: Catholic University of the Sacred Heart)
Overweight/obesity influence disease burden and clinical outcome of Rheumatoid Arthritis (RA). The impact of overweight/obesity on synovial tissue (ST) inflammation is largely unknown. Here, we investigated the histological and transcriptional signature of ST obtained from RA in different disease phases (disease onset, failure to first-line conventional DMARDs and in sustained clinical and ultrasound remission) finding that overweight/obese DMARDs naive RA showed higher likelihood of follicular ...
Published on May 7, 2019in Scientific Reports4.01
Jun Koarashi15
Estimated H-index: 15
(JAEA: Japan Atomic Energy Agency),
Syusaku Nishimura4
Estimated H-index: 4
(JAEA: Japan Atomic Energy Agency)
+ 2 AuthorsTakeshi Matsunaga13
Estimated H-index: 13
(JAEA: Japan Atomic Energy Agency)
The Fukushima Daiichi nuclear power plant accident caused serious radiocesium (137Cs) contamination of the soil in multiple terrestrial ecosystems. Soil is a complex system where minerals, organic matter, and microorganisms interact with each other; therefore, an improved understanding of the interactions of 137Cs with these soil constituents is key to accurately assessing the environmental consequences of the accident. Soil samples were collected from field, orchard, and forest sites in July 20...
Published on Feb 14, 2019in Scientific Reports4.01
Nina Levar (UvA: University of Amsterdam), Tessa J Van Doesum (UvA: University of Amsterdam)+ 1 AuthorsGuido van Wingen34
Estimated H-index: 34
(UvA: University of Amsterdam)
In recent years, resting-state (RS) networks and RS function have received increased attention, highlighting their importance in both cognitive function and psychopathology. The neurochemical substrates underlying RS networks and their interactions, however, have not yet been well established. Even though prior research has provided first evidence for a negative association between brain GABA levels and RS connectivity, these findings have been limited to within network connectivity, and not net...
Published on Jan 14, 2019in Scientific Reports4.01
Yali Qin3
Estimated H-index: 3
(Beijing University of Chinese Medicine),
Meiqi Ji (Beijing University of Chinese Medicine)+ 5 AuthorsMing Jin4
Estimated H-index: 4
(China-Japan Friendship Hospital)
Retinal hypoperfusion injury is the pathophysiologic basis of ocular ischemic syndrome (OIS) which often leads to severe visual loss. In this study, we aimed to establish a rat model of retinal chronic hypoperfusion by bilateral common carotid artery occlusion (BCCAO) and observe changes in the retinal function and morphology. We found that model rats showed retinal arteriosclerosis, slight dilated retinal vein, small hemangiomas, hemorrhages, vascular segmental filling, and nonperfused areas af...
Published on May 15, 2019in Scientific Reports4.01
Markus Hupp2
Estimated H-index: 2
(UZH: University of Zurich),
K. Vallotton (UZH: University of Zurich)+ 7 AuthorsArmin Curt51
Estimated H-index: 51
(UZH: University of Zurich)
Increased cranio-caudal spinal cord motion is associated with clinical impairment in degenerative cervical myelopathy. However, whether spinal cord motion holds potential as a neuroimaging biomarker requires further validation. Different confounders (i.e. subject characteristics, methodological problems such as phase drift, etc.) on spinal cord motion readouts have to be considered. Twenty-two healthy subjects underwent phase contrast MRI, a subset of subjects (N = 9) had repeated scans. Paramet...
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