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Siamak Beheshti
University of Isfahan
22Publications
6H-index
93Citations
Publications 22
Newest
Published on May 3, 2019in Scientific Reports 4.01
Elnaz Amanzadeh1
Estimated H-index: 1
(UI: University of Isfahan),
Abolghasem Esmaeili8
Estimated H-index: 8
(UI: University of Isfahan)
+ 3 AuthorsSiamak Beheshti6
Estimated H-index: 6
(UI: University of Isfahan)
Biomedical application of quercetin (QT) as an effective flavonoid has limitations due to its low bioavailability. Superparamagnetic iron oxide nanoparticle (SPION) is a novel drug delivery system that enhances the bioavailability of quercetin. The effect of short time usage of quercetin on learning and memory function and its signaling pathways in the healthy rat is not well understood. The aim of this study was to investigate the effect of free quercetin and in conjugation with SPION on learni...
Published on Dec 1, 2018in BMC Clinical Pharmacology
Rezvan Enteshari Najafabadi1
Estimated H-index: 1
(Shiraz University),
Nasrin Kazemipour7
Estimated H-index: 7
(Shiraz University)
+ 2 AuthorsSaeed Nazifi18
Estimated H-index: 18
(Shiraz University)
Background Quercetin (QT) as a bioactive flavonoid has a potential therapeutic activity for numerous neuronal injuries and neurodegenerative diseases. However, the low absorption rate of QT, especially through the blood-brain barrier, restricts its bioactivity in the body. The current research took the advantage of superparamagnetic iron oxide nanoparticles (SPIONs) to enhance the bioavailability of quercetin.
Published on Oct 1, 2018in Physiology & Behavior 2.63
Maryam Noorbakhshnia6
Estimated H-index: 6
(UI: University of Isfahan),
Arsham Rashidkaboli (UI: University of Isfahan)+ 1 AuthorsSiamak Beheshti6
Estimated H-index: 6
(UI: University of Isfahan)
Abstract Methamphetamine (METH) abuse is one the most worldwide problems with wide-ranging effects on the central nervous system (CNS). Chronic METH abuse can associate with cognitive abnormalities and neurodegenerative changes in the brain. Agmatine, a cationic polyamine, has been proposed as a neuromodulator that modulates many effects of abused drugs. The aim of this study was to determine if agmatine can decrease the impairment effect of METH on memory and hippocampal CaMKII-α gene expressio...
Published on Oct 1, 2018in International Journal of Developmental Neuroscience 2.37
Siamak Beheshti6
Estimated H-index: 6
(UI: University of Isfahan),
Azadeh Ghorbanpour Skakakomi (UI: University of Isfahan)+ 1 AuthorsHadi Dehestani (UI: University of Isfahan)
Abstract Background Frankincense is an oleo gum resin derived from trees of genus Boswellia. It has favorable effects on memory formation. However, the probable underlying molecular mechanisms have not been assessed. Frankincense exerts some of its effects via activation of protein kinases. Calcium/calmodulin kinaseII (CaMKII) and CaMKIV are crucial mediators of learning and memory. We studied the effect of maternal injection of the aqueous extract of frankincense during gestation and lactation ...
Published on Jul 2, 2018in Journal of HerbMed Pharmacology
Siamak Beheshti6
Estimated H-index: 6
,
Bahareh Shahmoradi
Introduction: Medicinal herbs have several components with different pharmacological effects. It has been described that Melissa officinalis is able to improve memory in different models of learning. Nevertheless, its influence has not been studied in animal models of AD. Here, we studied the potential therapeutic effect of M. officinalis in intracerebroventricular (i.c.v) amyloid-β (Aβ) model of Alzheimer’s disease (AD).Methods: Male Wistar rats weighing 260-330 g received the hydro-alcoholic e...
Published on Apr 10, 2018
Maryam Noorbakhshnia6
Estimated H-index: 6
(UI: University of Isfahan),
Neda Nazarizadeh Dehkordi (UI: University of Isfahan), Siamak Beheshti6
Estimated H-index: 6
(UI: University of Isfahan)
Published on Jan 1, 2018in Advanced Biomedical Research
Abolghasem Esmaeili8
Estimated H-index: 8
(UI: University of Isfahan),
RezvanEnteshari Najafabadi (Shiraz University)+ 2 AuthorsSaeed Nazifi18
Estimated H-index: 18
(Shiraz University)
Background: Superparamagnetic iron oxide nanoparticles (SPION) have been largely considered for numerous applications in biomedicine such as magnetic resonance imaging, hyperthermia, cell tracking, anticancer treatment, and targeted delivery of drugs or genes. However, they may have side effects such body weight loss. Quercetin (QT), a strong antioxidant and free radical scavenger and a natural flavonoid, has a wide range of biological and therapeutic effects. In this study, the effect of QT on ...
Published on Nov 1, 2017in Neuropeptides 2.41
Siamak Beheshti6
Estimated H-index: 6
(UI: University of Isfahan),
Neda Aslani (UI: University of Isfahan)
Abstract It is well known that the hormone ghrelin affects learning and memory in different experimental models of learning. Though, the effect of antagonism of ghrelin receptor type 1a (GHS-R1a) in various regions of the brain and on different stages of learning has not been examined. In this study the effect of injection of a GHS-R1a selective antagonist ( d -Lys-3-GHRP-6) into the basolateral amygdala, dentate gyrus or ventral tegmental area was examined on memory consolidation in the passive...
Published on Mar 1, 2017in Behavioural Brain Research 2.77
Siamak Beheshti6
Estimated H-index: 6
(UI: University of Isfahan),
Reyhaneh Zeinali1
Estimated H-index: 1
(UI: University of Isfahan),
Abolghasem Esmaeili8
Estimated H-index: 8
(UI: University of Isfahan)
Abstract Gap junction channels are implicated in learning and memory process. However, their role on each of the particular stages of memory formation has been studied less. In this study, the time profile of the expression levels of hippocampal connexins 36 and 45 (Cx36 and Cx45) mRNAs was measured during memory consolidation, in a passive avoidance paradigm. Totally 30 adult male rats were distributed into 5 groups of each 6. At different times profiles (30 min, 3, 6 and 24 h) following traini...
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