Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease
Abstract
Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted metabolomics that levels of phenyl sulfate, a gut microbiota-derived metabolite, increase with the progression of diabetes in rats overexpressing human uremic toxin transporter SLCO4C1 in the kidney, and are decreased in rats with limited proteinuria. In experimental models of diabetes, phenyl...
Paper Details
Title
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease
Published Date
Apr 23, 2019
Journal
Volume
10
Issue
1
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