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Effects of L-DOPA Monotherapy on Psychomotor Speed and [11C]Raclopride Binding in High-Risk Older Adults With Depression

Published on Apr 1, 2019in Biological Psychiatry 11.50
· DOI :10.1016/j.biopsych.2019.04.007
Bret R. Rutherford18
Estimated H-index: 18
(Columbia University),
Mark Slifstein53
Estimated H-index: 53
(SBU: Stony Brook University)
+ 8 AuthorsSteven P. Roose52
Estimated H-index: 52
(Columbia University)
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Abstract
Abstract Background A high-risk subgroup of older patients with depression has slowed processing and gait speeds. This study examined whether carbidopa/levodopa (L-DOPA) monotherapy increased dopamine availability, increased processing/gait speed, and relieved depressive symptoms. Methods Adult outpatients with depression >59 years old underwent baseline [ 11 C]raclopride positron emission tomography followed by open L-DOPA for 3 weeks (1 week each of 150 mg, 300 mg, and 450 mg). Generalized estimating equations tested the pre- and post-L-DOPA differences in processing and gait speed measures, depressive symptoms, and reported side effects. The decrease in binding potential between the pre- and posttreatment scans indexed enhanced synaptic dopamine availability induced by L-DOPA treatment. Results Thirty-six subjects participated (age, 75.3 ± 7.5 years; 44.4% male). Significant, dose-dependent increases in processing and gait speed were observed with L-DOPA (450-mg dose: processing speed factor score effect size = 0.41, p  = .001; dual-task gait speed effect size = 0.43, p  = .002). [ 11 C]raclopride decrease in binding potential was significantly different from 0 in sensorimotor ( t 24 = −4.85, p t 24  = −2.52, p  = .019) but not in limbic striatum ( t 24  = 0.265, p  = .793). Depressive symptoms decreased significantly on the Hamilton Rating Scale for Depression (effect size = −0.37, p  = .002). Dropout rate was 8.3%, and nausea was the most frequently reported side effect. Conclusions By enhancing availability of dopamine, L-DOPA improved processing and gait speed in older adults with depression and significantly decreased [ 11 C]raclopride binding in selected striatal subregions.
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Published on Nov 30, 2018in Clinical Neuropsychologist 2.01
Beate Gaertner10
Estimated H-index: 10
(RKI: Robert Koch Institute),
Michael M. Wagner112
Estimated H-index: 112
(German Center for Neurodegenerative Diseases)
+ 3 AuthorsMarkus Busch25
Estimated H-index: 25
(RKI: Robert Koch Institute)
ABSTRACTObjective: To provide normative data for the Digit Symbol Substitution Test (DSST) of the Wechsler Adult Intelligence Scale, 3rd edition (WAIS-III) in a population-based sample of community-dwelling older adults in Germany according to age, sex, and level of education.Method: The sample comprised 1385 participants aged 65–79 years from the nationwide representative ‘German Health Interview and Examination Survey for Adults’ (DEGS1, 2008–2011). Participants with known cognitive impairment...
Published on Dec 5, 2017in American Journal of Psychiatry 13.65
Bret R. Rutherford18
Estimated H-index: 18
,
Katharine K. Brewster2
Estimated H-index: 2
+ 2 AuthorsSteven P. Roose52
Estimated H-index: 52
Recent research has linked age-related hearing loss to impaired performance across cognitive domains and increased risk for dementia diagnosis. The data linking hearing impairment to incident late-life depression are more mixed but suggest that diminished hearing does increase risk for depression. Behavioral mechanisms may explain these associations, such as the withdrawal of older adults from situations in which they may have difficulty hearing and communicating, which may contribute to the dev...
Published on Aug 3, 2017in Frontiers in Human Neuroscience 2.87
Olivier Beauchet8
Estimated H-index: 8
(McGill University),
Gilles Allali31
Estimated H-index: 31
(University of Geneva)
+ 19 AuthorsCyrille P. Launay13
Estimated H-index: 13
Background. Gait disorders, a highly prevalent condition in older adults, are associated with several adverse health consequences. Gait analysis allows qualitative and quantitative assessments of gait that improves the understanding of mechanisms of gait disorders and the choice of interventions. This manuscript aims 1) to give consensus guidance for clinical and spatiotemporal gait analysis based on the recorded footfalls in older adults aged 65 years and over, and 2) to provide reference value...
Published on Feb 1, 2017in American Journal of Psychiatry 13.65
Bret R. Rutherford18
Estimated H-index: 18
,
Melanie M. Wall64
Estimated H-index: 64
+ 6 AuthorsSteven P. Roose52
Estimated H-index: 52
Objective:Causes of placebo effects in antidepressant trials have been inferred from observational studies and meta-analyses, but their mechanisms have not been directly established. The goal of this study was to examine in a prospective, randomized controlled trial whether patient expectancy mediates placebo effects in antidepressant studies.Method:Adult outpatients with major depressive disorder were randomly assigned to open or placebo-controlled citalopram treatment. Following measurement of...
Published on Nov 1, 2016in American Journal of Geriatric Psychiatry 3.49
Patrick J. Brown14
Estimated H-index: 14
(Columbia University),
Bret R. Rutherford18
Estimated H-index: 18
(Columbia University)
+ 5 AuthorsSteven P. Roose52
Estimated H-index: 52
(Columbia University)
Depression in later life is a severe public health problem, associated with higher rates of mortality, suicide, and dementia. Effectiveness of treatment is limited by the failure to deconstruct the heterogeneity of the illness and because diagnostic criteria, pathophysiological models, and treatment algorithms for depression are primarily based on studies of younger adults even though symptoms of the illness and physiology of the patient change with age. Thus, understanding how aging interacts w...
Published on Jul 1, 2016in The Lancet Psychiatry 18.33
Saira Saeed Mirza14
Estimated H-index: 14
(EUR: Erasmus University Rotterdam),
Frank J. Wolters12
Estimated H-index: 12
(EUR: Erasmus University Rotterdam)
+ 4 AuthorsM. Arfan Ikram71
Estimated H-index: 71
(EUR: Erasmus University Rotterdam)
Summary Background Late-life depressive symptoms have been extensively studied for their relationship with incident dementia, but have been typically assessed at a single timepoint. Such an approach neglects the course of depression, which, given its remitting and relapsing nature, might provide further insights into the complex association of depression with dementia. We therefore repeatedly measured depressive symptoms in a population of adults over a decade to study the subsequent risk of dem...
Published on May 1, 2016in JAMA Psychiatry 15.92
Allison R. Kaup12
Estimated H-index: 12
(UCSF: University of California, San Francisco),
Amy L. Byers25
Estimated H-index: 25
(UCSF: University of California, San Francisco)
+ 6 AuthorsKristine Yaffe113
Estimated H-index: 113
Importance Depression has been identified as a risk factor for dementia. However, most studies have measured depressive symptoms at only one time point, and older adults may show different patterns of depressive symptoms over time. Objective To investigate the association between trajectories of depressive symptoms and risk of dementia in older adults. Design, Setting, and Participants This was a prospective cohort investigation of black and white community-dwelling older adults in the Health, A...
Patrick J. Brown14
Estimated H-index: 14
(Columbia University),
Steven P. Roose52
Estimated H-index: 52
(Columbia University)
+ 9 AuthorsSuzanne Satterfield61
Estimated H-index: 61
(UTHSC: University of Tennessee Health Science Center)
Inflammation, slow gait, and depression individually are associated with mortality, yet little is known about the trajectories of these measures, their interrelationships, or their collective impact on mortality.Longitudinal latent class analysis was used to evaluate trajectories of depression (Center for Epidemiologic Studies Depression ≥ 10), slow gait ( 3.2 pg/mL) using data from the Health Aging and Body Composition Study. Logistic regression was used to identify their associations with mort...
Published on Jan 19, 2016in PLOS ONE 2.78
Catherine C. Price22
Estimated H-index: 22
(UF: University of Florida),
Jared J. Tanner7
Estimated H-index: 7
(UF: University of Florida)
+ 7 AuthorsDawn Bowers45
Estimated H-index: 45
(UF: University of Florida)
Objective This prospective investigation examined: 1) processing speed and working memory relative to other cognitive domains in non-demented medically managed idiopathic Parkinson’s disease, and 2) the predictive role of cortical/subcortical gray thickness/volume and white matter fractional anisotropy on processing speed and working memory. Methods Participants completed a neuropsychological protocol, Unified Parkinson’s Disease Rating Scale, brain MRI, and fasting blood draw to rule out vascul...
Published on Aug 1, 2015in Neuroscience & Biobehavioral Reviews 8.00
Chong Chen6
Estimated H-index: 6
(Hokkaido University),
T. Takahashi38
Estimated H-index: 38
(Hokkaido University)
+ 2 AuthorsIchiro Kusumi30
Estimated H-index: 30
(Hokkaido University)
Abstract Despite being considered primarily a mood disorder, major depressive disorder (MDD) is characterized by cognitive and decision making deficits. Recent research has employed computational models of reinforcement learning (RL) to address these deficits. The computational approach has the advantage in making explicit predictions about learning and behavior, specifying the process parameters of RL, differentiating between model-free and model-based RL, and the computational model-based func...
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