Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting
Abstract
Na + /H + antiporters exchange sodium ions and protons on opposite sides of lipid membranes. The electroneutral Na + /H + antiporter NhaP from archaea Pyrococcus abyssi (PaNhaP) is a functional homolog of the human Na + /H + exchanger NHE1, which is an important drug target. Here we resolve the Na + and H + transport cycle of PaNhaP by transition-path sampling. The resulting molecular dynamics trajectories of repeated ion transport events...
Paper Details
Title
Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting
Published Date
Apr 15, 2019
Journal
Volume
10
Issue
1
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