Match!
Gerhard Hummer
Goethe University Frankfurt
338Publications
67H-index
17kCitations
Publications 338
Newest
#1Ramachandra M. Bhaskara (MPG: Max Planck Society)H-Index: 7
#2Paolo Grumati (Goethe University Frankfurt)H-Index: 24
Last.Gerhard Hummer (Goethe University Frankfurt)H-Index: 67
view all 9 authors...
FAM134B/RETREG1 is a selective ER-phagy receptor that regulates the size and shape of the endoplasmic reticulum. The structure of its reticulon-homology domain (RHD), an element shared with other ER-shaping proteins, and the mechanism of membrane shaping remain poorly understood. Using molecular modeling and molecular dynamics (MD) simulations, we assemble a structural model for the RHD of FAM134B. Through MD simulations of FAM134B in flat and curved membranes, we relate the dynamic RHD structur...
#1Kei-ichi Okazaki (MPG: Max Planck Society)H-Index: 9
#2David Wöhlert (MPG: Max Planck Society)H-Index: 4
Last.Gerhard Hummer (Goethe University Frankfurt)H-Index: 67
view all 7 authors...
Na+/H+ antiporters exchange sodium ions and protons on opposite sides of lipid membranes. The electroneutral Na+/H+ antiporter NhaP from archaea Pyrococcus abyssi (PaNhaP) is a functional homolog of the human Na+/H+ exchanger NHE1, which is an important drug target. Here we resolve the Na+ and H+ transport cycle of PaNhaP by transition-path sampling. The resulting molecular dynamics trajectories of repeated ion transport events proceed without bias force, and overcome the enormous time-scale gap...
#1Yung-Ning Chang (Goethe University Frankfurt)H-Index: 2
#2Eva A. Jaumann (Goethe University Frankfurt)H-Index: 2
Last.Eric R. Geertsma (Goethe University Frankfurt)H-Index: 15
view all 8 authors...
The SLC26 family of transporters maintains anion equilibria in all kingdoms of life. The family shares a 7 + 7 transmembrane segments inverted repeat architecture with the SLC4 and SLC23 families, but holds a regulatory STAS domain in addition. While the only experimental SLC26 structure is monomeric, SLC26 proteins form structural and functional dimers in the lipid membrane. Here we resolve the structure of an SLC26 dimer embedded in a lipid membrane and characterize its functional relevance by...
#1Tim N. Baldering (Goethe University Frankfurt)
#2Jakob Bullerjahn (MPG: Max Planck Society)
Last.Sebastian Malkusch (Goethe University Frankfurt)H-Index: 12
view all 0 authors...
#1Marc Siggel (MPG: Max Planck Society)
#2Ramachandra M. Bhaskara (MPG: Max Planck Society)H-Index: 7
Last.Gerhard Hummer (Goethe University Frankfurt)H-Index: 67
view all 0 authors...
#1Kristina Vaeth (Saarland University)
#2Roberto Covino (MPG: Max Planck Society)H-Index: 7
Last.Robert Ernst (Saarland University)H-Index: 15
view all 5 authors...
The endoplasmic reticulum (ER) is a key organelle of membrane biogenesis and crucial for the folding of both membrane and secretory proteins. Stress sensors of the unfolded protein response (UPR) monitor the unfolded protein load in the ER and convey effector functions for the maintenance of ER homeostasis. More recently, it became clear that aberrant compositions of the ER membrane, referred to as lipid bilayer stress, are equally potent activators of the UPR with important implications in obes...
#1Lisa M Pietrek (MPG: Max Planck Society)
#2Lukas S. Stelzl (MPG: Max Planck Society)H-Index: 5
Last.Gerhard Hummer (MPG: Max Planck Society)H-Index: 67
view all 0 authors...
Intrinsically disordered proteins (IDPs) constitute a large fraction of the human proteome and are critical in the regulation of cellular processes. A detailed understanding of the conformational dynamics of IDPs could help to elucidate their roles in health and disease. However the inherent flexibility of IDPs makes structural studies and their interpretation challenging. Molecular dynamics (MD) simulations could address this challenge in principle, but inaccuracies in the simulation models and...
Cryo-electron microscopy is a revolutionary technique that can provide 3D density maps at near-atomic resolution. However, map validation is still an open issue in the field. Despite several efforts from the community, it is possible to overfit the reconstructions to noisy data. Here, inspired by modern statistics, we develop a novel methodology that uses a small independent particle set to validate the 3D maps. The main idea is to monitor how the map probability evolves over the control set dur...
12345678910