IS THE INCIDENCE RATE OF ASCVD EVENTS IN THE PLACEBO ARM OF RANDOMIZED TRIALS ASSOCIATED WITH THE TREATMENT EFFECT OF ASPIRIN FOR PRIMARY PREVENTION? A META-REGRESSION ANALYSIS

Aspirin (ASA) is often taken for the primary prevention of atherosclerotic cardiovascular disease (ASCVD). We tested the hypothesis that ASA is more efficacious for preventing ASCVD as the incidence rate of ASCVD increases. Randomized controlled trials (RCTs) that compared ASA to placebo...