The ‘Timing Hypothesis’ states that the benefits and harms of hormone replacement therapy (HRT) are related to the proximity with which it is begun following the onset of menopause. The objective of this study is to compare the risk of cardiac and thromboembolic events among women who are
Sacubitril/valsartan has emerged as a new therapy for patients with heart failure with reduced ejection fraction. While its efficacy has been shown, less is known about its safety profile. A meta-analysis was performed using randomized controlled trials (RCTs) testing sacubitril/valsartan. The
AbstractObjective:Data in humans and nonhuman primates have suggested a possible synergistic effect of vitamin D and calcium (CaD) and estrogen on the cardiovascular disease (CVD) risk factors. Using randomized trial data we explored whether the effect of menopausal hormone therapy (HT) on CVD event
#2Matthew Nudy(Penn State Milton S. Hershey Medical Center)H-Index: 5
Last. Mohammed Ruzieh(Penn State Milton S. Hershey Medical Center)H-Index: 1
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In systemic lupus erythematous (SLE), cardiac involvement is common as pericarditis is considered one of the diagnostic criteria. Overt myocarditis, however, is rare and not considered in the standard diagnostic criteria for SLE. Cardiogenic shock secondary to lupus myocarditis may seldomly be the
Last. Andrew Foy(Penn State Milton S. Hershey Medical Center)H-Index: 8
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Aspirin (ASA) is often taken for the primary prevention of atherosclerotic cardiovascular disease (ASCVD). We tested the hypothesis that ASA is more efficacious for preventing ASCVD as the incidence rate of ASCVD increases. Randomized controlled trials (RCTs) that compared ASA to placebo for
Last. Andrew Foy(PSU: Pennsylvania State University)H-Index: 8
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Abstract Background The ‘Timing Hypothesis’ states that the benefits and harms of hormone replacement therapy (HRT) are related to the proximity with which it is begun following the onset of menopause. The primary aim of this analysis was to test for heterogeneity of treatment effect for HRT using Chi2 and I2 tests for younger versus older initiators of HRT. The secondary aim was to perform a meta-regression with mean age at trial baseline as the covariate for various outcomes. Methods Younger i...
Purpose A proportion of patients with vasovagal syncope (VVS) experience recurrence despite appropriate management. Closed loop stimulation (CLS) pacing is a promising treatment for a subgroup of patients with cardioinhibitory response on head-up tilt table test (HUTT). Nonetheless, its efficacy remains uncertain. We sought to assess the efficacy of CLS pacing in patients with cardioinhibitory VVS.