Original paper
Genome-wide target specificity of CRISPR RNA-guided adenine base editors
Abstract
Adenine base editors1 enable efficient targeted adenine-to-guanine single nucleotide conversions to induce or correct point mutations in human cells, animals, and plants1–4. Here we present a modified version of Digenome-seq, an in vitro method for identifying CRISPR (clustered regularly interspaced short palindromic repeats)-induced double-strand breaks using whole-genome sequencing5–8, to assess genome-wide target specificity of adenine base...
Paper Details
Title
Genome-wide target specificity of CRISPR RNA-guided adenine base editors
Published Date
Mar 4, 2019
Journal
Volume
37
Issue
4
Pages
430 - 435
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Notes
History