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Nature Biotechnology
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#1Xingcong Ma (Xi'an Jiaotong University)H-Index: 1
#2Peishun Shou (UNC: University of North Carolina at Chapel Hill)
Last.Benjamin G. Vincent (UNC: University of North Carolina at Chapel Hill)H-Index: 18
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Cytokines that stimulate T cell proliferation, such as interleukin (IL)-15, have been explored as a means of boosting the antitumor activity of chimeric antigen receptor (CAR) T cells. However, constitutive cytokine signaling in T cells and activation of bystander cells may cause toxicity. IL-23 is a two-subunit cytokine known to promote proliferation of memory T cells and T helper type 17 cells. We found that, upon T cell antigen receptor (TCR) stimulation, T cells upregulated the IL-23 recepto...
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#1Daniel Ramsköld (KI: Karolinska Institutet)H-Index: 16
#2Shujun Luo (Illumina)H-Index: 38
Last.Louise C. Laurent (UCSD: University of California, San Diego)H-Index: 36
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#1Greta Giordano-Attianese (Ludwig Institute for Cancer Research)
#2Pablo Gainza (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 2
Last.Patrick Reichenbach (Ludwig Institute for Cancer Research)
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Approaches to increase the activity of chimeric antigen receptor (CAR)-T cells against solid tumors may also increase the risk of toxicity and other side effects. To improve the safety of CAR-T-cell therapy, we computationally designed a chemically disruptable heterodimer (CDH) based on the binding of two human proteins. The CDH self-assembles, can be disrupted by a small-molecule drug and has a high-affinity protein interface with minimal amino acid deviation from wild-type human proteins. We i...
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#1Amy E. Young (UC Davis: University of California, Davis)H-Index: 15
#2Tamer Mansour (UC Davis: University of California, Davis)H-Index: 7
Last.Alison L. Van Eenennaam (UC Davis: University of California, Davis)H-Index: 27
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#1Amjad Askary (California Institute of Technology)H-Index: 1
#2Luis Óscar Sánchez-Guardado (California Institute of Technology)H-Index: 6
Last.Michael B. Elowitz (California Institute of Technology)H-Index: 49
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The n-Lorem Foundation seeks to provide therapies for ultra-rare diseases free of charge The n-Lorem Foundation seeks to provide therapies for ultra-rare diseases free of charge
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#1Stefan Howorka (UCL: University College London)H-Index: 36
#2Zuzanna S. Siwy (UCI: University of California, Irvine)H-Index: 43
In a step toward nanopore sequencing of proteins, an aerolysin pore discriminates many of the proteinogenic amino acids.
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#1Paul C. Godfrey (BYU: Brigham Young University)H-Index: 14
#2Gove N. Allen (BYU: Brigham Young University)H-Index: 8
Last.David Benson (UVU: Utah Valley University)
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A detailed look at the economic impact of university-licensed life science startups across the United States reveals vast differences in the effectiveness of different regions to create ventures and sustain them as viable entities.
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