Nature Biotechnology
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Published on Mar 1, 2019in Nature Biotechnology 35.72
T. Deuse23
Estimated H-index: 23
(University of California, San Francisco),
X. Hu2
Estimated H-index: 2
(University of California, San Francisco)
+ 10 AuthorsReichenspurnerHermann51
Estimated H-index: 51
Autologous induced pluripotent stem cells (iPSCs) constitute an unlimited cell source for patient-specific cell-based organ repair strategies. However, their generation and subsequent differentiation into specific cells or tissues entail cell line-specific manufacturing challenges and form a lengthy process that precludes acute treatment modalities. These shortcomings could be overcome by using prefabricated allogeneic cell or tissue products, but the vigorous immune response against histo-incom...
2 Citations Source Cite
Published on Jan 3, 2019in Nature Biotechnology 35.72
Marko Hakovirta , Lucian A. Lucia27
Estimated H-index: 27
The bioeconomy demands special approaches for attracting youth to science, technology, engineering and mathematics disciplines and cultivating the multidisciplinary skills needed for a future workforce.
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Published on Jan 3, 2019in Nature Biotechnology 35.72
Jessica M. Stringer10
Estimated H-index: 10
(Discovery Institute),
Patrick S. Western25
Estimated H-index: 25
The generation of immature human oocytes in vitro highlights the challenges of folliculogenesis.
1 Citations Source Cite
Published on Mar 1, 2019in Nature Biotechnology 35.72
Narayanan Narayanan5
Estimated H-index: 5
(Donald Danforth Plant Science Center),
Getu Beyene14
Estimated H-index: 14
(Donald Danforth Plant Science Center)
+ 11 AuthorsDulce M. Jiménez-Aguilar2
Estimated H-index: 2
(Baylor College of Medicine)
In the version of this article initially published, a relevant work was not cited. The following sentence has been inserted following the sentence ending “Aspergillus phytase” in the third paragraph of the article: “Overexpression of AtIRT1, AtNAS1 and bean FERRITIN in rice resulted in 3.8-fold higher iron and 1.8-fold higher zinc concentrations than in the wild-type control12.” A corresponding reference has been added: 12. Boonyaves, K., Wu, T. Y., Gruissem, W. & Bhullar, N. K. Enhanced grain i...
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Published on Mar 18, 2019in Nature Biotechnology 35.72
Shaoya Li3
Estimated H-index: 3
,
Jingying Li4
Estimated H-index: 4
+ 5 AuthorsLanqin Xia12
Estimated H-index: 12
One of the main obstacles to gene replacement in plants is efficient delivery of a donor repair template (DRT) into the nucleus for homology-directed DNA repair (HDR) of double-stranded DNA breaks. Production of RNA templates in vivo for transcript-templated HDR (TT-HDR) could overcome this problem, but primary transcripts are often processed and transported to the cytosol, rendering them unavailable for HDR. We show that coupling CRISPR-Cpf1 (CRISPR from Prevotella and Francisella 1) to a CRISP...
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Published on Mar 1, 2019in Nature Biotechnology 35.72
Timothy Kelliher11
Estimated H-index: 11
(Research Triangle Park),
Dakota Starr (University of Georgia)+ 14 AuthorsErin Burch (Research Triangle Park)
Genome editing using CRISPR–Cas9 works efficiently in plant cells1, but delivery of genome-editing machinery into the vast majority of crop varieties is not possible using established methods2. We co-opted the aberrant reproductive process of haploid induction (HI)3–6 to induce edits in nascent seeds of diverse monocot and dicot species. Our method, named HI-Edit, enables direct genomic modification of commercial crop varieties. HI-Edit was tested in field and sweet corn using a native haploid-i...
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Published on Mar 1, 2019in Nature Biotechnology 35.72
Chun Wang7
Estimated H-index: 7
(Rice University),
Qing Liu8
Estimated H-index: 8
(Rice University)
+ 8 AuthorsRaphael Mercier26
Estimated H-index: 26
(Université Paris-Saclay)
Heterosis, or hybrid vigor, is exploited by breeders to produce elite high-yielding crop lines, but beneficial phenotypes are lost in subsequent generations owing to genetic segregation. Clonal propagation through seeds would enable self-propagation of F1 hybrids. Here we report a strategy to enable clonal reproduction of F1 rice hybrids through seeds. We fixed the heterozygosity of F1 hybrid rice by multiplex CRISPR–Cas9 genome editing of the REC8, PAIR1 and OSD1 meiotic genes to produce clonal...
1 Citations Source Cite
Published on Mar 15, 2019in Nature Biotechnology 35.72
Donna Dickenson8
Estimated H-index: 8
(University of Bristol),
Marcy Darnovsky1
Estimated H-index: 1
(University of California, Berkeley)
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Published on Feb 1, 2019in Nature Biotechnology 35.72
Elie Dolgin4
Estimated H-index: 4
In the version of this article initially published, Betalutin was described as directing a radioisotope to CD45-expressing B cells; in fact, it directs it to CD37-expressing B cells. The error has been corrected in the HTML and PDF versions of the article.
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Published on Jan 21, 2019in Nature Biotechnology 35.72
Elie Dolgin4
Estimated H-index: 4
Link to α-synuclein builds case for inflammasome targeting to treat Parkinson’s disease. Link to α-synuclein builds case for inflammasome targeting to treat Parkinson’s disease.
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