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Nature Biotechnology
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Published in Nature Biotechnology31.86
Melanie Senior6
Estimated H-index: 6
A ten-year collaboration gives biotech giant Gilead first rights to all of Galapagos’s pipeline. A ten-year collaboration gives biotech giant Gilead first rights to all of Galapagos’s pipeline.
Published in Nature Biotechnology31.86
Selena Lorrey (Duke University), Luis Sanchez-Perez25
Estimated H-index: 25
(Duke University),
Peter E. Fecci19
Estimated H-index: 19
(Duke University)
Targeting two antigens with BiTE-secreting CAR-T cells limits tumor immune escape in glioblastoma.
Published in Nature Biotechnology31.86
T. Deuse23
Estimated H-index: 23
(UCSF: University of California, San Francisco),
X. Hu2
Estimated H-index: 2
(UCSF: University of California, San Francisco)
+ -3 AuthorsZeynep Koşaloğlu-Yalçın (La Jolla Institute for Allergy and Immunology)
The utility of autologous induced pluripotent stem cell (iPSC) therapies for tissue regeneration depends on reliable production of immunologically silent functional iPSC derivatives. However, rejection of autologous iPSC-derived cells has been reported, although the mechanism underlying rejection is largely unknown. We hypothesized that de novo mutations in mitochondrial DNA (mtDNA), which has far less reliable repair mechanisms than chromosomal DNA, might produce neoantigens capable of elicitin...
Published in Nature Biotechnology31.86
Sinem K. Saka7
Estimated H-index: 7
(Wyss Institute for Biologically Inspired Engineering),
Yu Wang4
Estimated H-index: 4
(Wyss Institute for Biologically Inspired Engineering)
+ -3 AuthorsBrian J. Beliveau10
Estimated H-index: 10
(Wyss Institute for Biologically Inspired Engineering)
Spatial mapping of proteins in tissues is hindered by limitations in multiplexing, sensitivity and throughput. Here we report immunostaining with signal amplification by exchange reaction (Immuno-SABER), which achieves highly multiplexed signal amplification via DNA-barcoded antibodies and orthogonal DNA concatemers generated by primer exchange reaction (PER). SABER offers independently programmable signal amplification without in situ enzymatic reactions, and intrinsic scalability to rapidly am...
Published in Nature Biotechnology31.86
Rida Mourtada2
Estimated H-index: 2
(MIT: Massachusetts Institute of Technology),
Henry D. Herce (Harvard University)+ -3 AuthorsLoren D. Walensky46
Estimated H-index: 46
(Harvard University)
The clinical translation of cationic α-helical antimicrobial peptides (AMPs) has been hindered by structural instability, proteolytic degradation and in vivo toxicity from nonspecific membrane lysis. Although analyses of hydrophobic content and charge distribution have informed the design of synthetic AMPs with increased potency and reduced in vitro hemolysis, nonspecific membrane toxicity in vivo continues to impede AMP drug development. Here, we analyzed a 58-member library of stapled AMPs (St...
Published in Nature Biotechnology31.86
Benjamin W. Thuronyi3
Estimated H-index: 3
(Williams College),
Luke W. Koblan2
Estimated H-index: 2
(Broad Institute)
+ -3 AuthorsJeffrey R. Holt32
Estimated H-index: 32
(Boston Children's Hospital)
Published in Nature Biotechnology31.86
James A. Frank9
Estimated H-index: 9
(MIT: Massachusetts Institute of Technology),
Marc-Joseph Antonini (MIT: Massachusetts Institute of Technology), Polina Anikeeva21
Estimated H-index: 21
(MIT: Massachusetts Institute of Technology)
Monitoring and modulating the diversity of signals used by neurons and glia in a closed-loop fashion is necessary to establish causative links between biochemical processes within the nervous system and observed behaviors. As developments in neural-interface hardware strive to keep pace with rapid progress in genetically encoded and synthetic reporters and modulators of neural activity, the integration of multiple functional features becomes a key requirement and a pressing challenge in the fiel...
Published in Nature Biotechnology31.86
Aaron M. Wenger4
Estimated H-index: 4
(Pacific Biosciences),
Paul Peluso16
Estimated H-index: 16
(Pacific Biosciences)
+ -3 AuthorsNathan D. Olson7
Estimated H-index: 7
(NIST: National Institute of Standards and Technology)
The DNA sequencing technologies in use today produce either highly accurate short reads or less-accurate long reads. We report the optimization of circular consensus sequencing (CCS) to improve the accuracy of single-molecule real-time (SMRT) sequencing (PacBio) and generate highly accurate (99.8%) long high-fidelity (HiFi) reads with an average length of 13.5 kilobases (kb). We applied our approach to sequence the well-characterized human HG002/NA24385 genome and obtained precision and recall r...
Published in Nature Biotechnology31.86
Emily Waltz11
Estimated H-index: 11
Non-invasive stimulation of the brain is being touted to promote health and well-being and for ‘curing’ disease, but the mechanistic underpinnings of the devices remain unclear.
Published in Nature Biotechnology31.86
Eric Smalley3
Estimated H-index: 3
Despite dazzling lab demonstrations, robust and viable clinical interventions using brain–computer interfaces remain some way off.
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