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Daesik Kim
Seoul National University
65Publications
12H-index
2,045Citations
Publications 65
Newest
Published on Jun 20, 2019in Annual Review of Biochemistry 20.15
Daesik Kim12
Estimated H-index: 12
,
Kevin Luk2
Estimated H-index: 2
(University of Massachusetts Medical School)
+ 1 AuthorsJinsoo Kim49
Estimated H-index: 49
Programmable nucleases and deaminases, which include zinc-finger nucleases, transcription activator-like effector nucleases, CRISPR RNA-guided nucleases, and RNA-guided base editors, are now widely employed for the targeted modification of genomes in cells and organisms. These gene-editing tools hold tremendous promise for therapeutic applications. Importantly, these nucleases and deaminases may display off-target activity through the recognition of near-cognate DNA sequences to their target sit...
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Published on Apr 1, 2019in Nature Biotechnology 35.72
Daesik Kim12
Estimated H-index: 12
(Seoul National University),
Da-eun Kim3
Estimated H-index: 3
(Seoul National University)
+ 2 AuthorsJin-Soo Kim52
Estimated H-index: 52
(Seoul National University)
Adenine base editors1 enable efficient targeted adenine-to-guanine single nucleotide conversions to induce or correct point mutations in human cells, animals, and plants1–4. Here we present a modified version of Digenome-seq, an in vitro method for identifying CRISPR (clustered regularly interspaced short palindromic repeats)-induced double-strand breaks using whole-genome sequencing5–8, to assess genome-wide target specificity of adenine base editors. To produce double-strand breaks at sites co...
8 Citations Source Cite
Published on Mar 1, 2019in Advanced Science 12.44
Jaeyoung Yoon3
Estimated H-index: 3
(Seoul National University),
Yunsik Joo3
Estimated H-index: 3
(Seoul National University)
+ 6 AuthorsYongtaek Hong25
Estimated H-index: 25
(Seoul National University)
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Published on Mar 1, 2019in Advanced Science 12.44
Jaeyoung Yoon3
Estimated H-index: 3
(Seoul National University),
Yunsik Joo3
Estimated H-index: 3
(Seoul National University)
+ 6 AuthorsYongtaek Hong25
Estimated H-index: 25
(Seoul National University)
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Published on Feb 1, 2019in Smart Materials and Structures 2.96
Taehoon Kim34
Estimated H-index: 34
(Seoul National University),
Daesik Kim12
Estimated H-index: 12
(Seoul National University)
+ 3 AuthorsYongtaek Hong25
Estimated H-index: 25
(Seoul National University)
Conductive thin films are typically subject to crack formation and propagation under tensile strain, turning into insulating films due to complete breakage at large strain. However, if such crack propagation can be intentionally designed, repetitive resistance change can be obtained and used for implementation of high-performance strain sensors that are suitable for biocompatible and stretchable electronic applications. In this work, therefore, we introduce a fiber-reinforced region, which is fo...
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Published on Jan 1, 2019
Jae young Lee , Ji-Su Lee3
Estimated H-index: 3
+ 11 AuthorsJung Min Lee10
Estimated H-index: 10
Published on Dec 1, 2018in Nature Communications 12.35
Jungjoon K. Lee2
Estimated H-index: 2
,
Euihwan Jeong5
Estimated H-index: 5
(Seoul National University)
+ 8 AuthorsSeokjoong Kim14
Estimated H-index: 14
The use of CRISPR-Cas9 as a therapeutic reagent is hampered by its off-target effects. Although rationally designed S. pyogenes Cas9 (SpCas9) variants that display higher specificities than the wild-type SpCas9 protein are available, these attenuated Cas9 variants are often poorly efficient in human cells. Here, we develop a directed evolution approach in E. coli to obtain Sniper-Cas9, which shows high specificities without killing on-target activities in human cells. Unlike other engineered Cas...
18 Citations Source Cite
Published on Dec 1, 2018in Genome Research 10.10
Daesik Kim12
Estimated H-index: 12
(Seoul National University),
Jin-Soo Kim52
Estimated H-index: 52
(Seoul National University)
2 Citations Source Cite
Published on Dec 1, 2018in Advanced Functional Materials 13.32
Eunho Oh5
Estimated H-index: 5
(Seoul National University),
Taehoon Kim34
Estimated H-index: 34
(Seoul National University)
+ 7 AuthorsYongtaek Hong25
Estimated H-index: 25
(Seoul National University)
Source Cite
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