Essential Residues Required for the Opening of a Polycystin TRP Channel

Polycystins (PKD2 and homologs) belong in the family of the Transient Receptor Potential (TRP) nonselective cation channels. Their biophysics and cellular functions are still poorly understood, except for their association with autosomal dominant polycystic kidney disease (ADPKD), a common monogenetic disorder characterized by proliferative cysts which leads to renal failure in adulthood. TRP channels are known to be stimulated by a wide range...