Combined sleep deprivation and light therapy: Clinical treatment outcomes in patients with complex unipolar and bipolar depression

The combination of sleep deprivation and light therapy, called combined chronotherapy, may yield positive short- and long-term results, even in patients with treatment resistant depression (TRD). The implementation of combined chronotherapy in daily clinical practice is rare. This study describes the implementation and the effectiveness in a clinical setting. Twenty six depressed patients with unipolar or bipolar depression received combined...