Original paper
Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants
Abstract
The most severe manifestation of peripheral arterial disease (PAD) is critical limb ischemia (CLI). CLI patients suffer high rates of amputation and mortality; accordingly, there remains a clear need both to better understand CLI and to develop more effective treatments. Gastrocnemius muscle was obtained from 32 older (51–84 years) non-PAD controls, 27 claudicating PAD patients (ankle-brachial index [ABI] 0.65 ± 0.21 SD), and 19 CLI patients...
Paper Details
Title
Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants
Published Date
Nov 2, 2018
Journal
Volume
3
Issue
21
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Notes
History