Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead

Neurofibrillary pathology comprised of pathological tau protein is closely tied to a range of neurodegenerative disorders, the most common of which is Alzheimer's disease. While they are individually rarer, a range of other disorders, the tauopathies (including Pick's disease, progressive supranuclear palsy, corticobasal degeneration, and primary progressive aphasia) display pronounced underlying tau pathology. In all cases, the distribution and...