TOE1 acts as a 3′ exonuclease for telomerase RNA and regulates telomere maintenance
Abstract
In human cells, telomeres are elongated by the telomerase complex that contains the reverse transcriptase hTERT and RNA template TERC/hTR. Poly(A)-specific ribonuclease (PARN) is known to trim hTR precursors by removing poly(A) tails. However, the precise mechanism of hTR 3' maturation remains largely unknown. Target of Egr1 (TOE1) is an Asp-Glu-Asp-Asp (DEDD) domain containing deadenylase that is mutated in the human disease Pontocerebella...
Paper Details
Title
TOE1 acts as a 3′ exonuclease for telomerase RNA and regulates telomere maintenance
Published Date
Oct 29, 2018
Journal
Volume
47
Issue
1
Pages
391 - 405
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