Zhou Songyang
Sun Yat-sen University
Publications 125
#1Weisi Lu (SYSU: Sun Yat-sen University)H-Index: 7
#2Jianping Yu (SYSU: Sun Yat-sen University)
Last.Junjiu Huang (SYSU: Sun Yat-sen University)H-Index: 19
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Background Small nucleolar RNA host gene 3 (Snhg3) is a long non-coding RNA (lncRNA) that was shown to participate in the tumorigenesis of certain cancers. However, little is known about its role in embryonic stem cells (ESCs).
#1Zhenhua Luo (SYSU: Sun Yat-sen University)H-Index: 6
#2Weixu Wang (SCAU: South China Agricultural University)
Last.Yuanyan Xiong (SYSU: Sun Yat-sen University)H-Index: 7
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Cancer cells become immortalized through telomere maintenance mechanisms, such as telomerase reverse transcriptase (TERT) activation. In addition to maintaining telomere length, TERT activates manifold cell survival signaling pathways. However, telomerase-associated gene signatures in cancer remain elusive. We performed a systematic analysis of TERT high (TERThigh) and low (TERTlow) cancers using multidimensional data from The Cancer Genome Atlas (TCGA). Multidimensional data were analyzed by pr...
#1Puping Liang (SYSU: Sun Yat-sen University)H-Index: 8
#2Xiaowei Xie (SYSU: Sun Yat-sen University)H-Index: 7
Last.Zhou SongyangH-Index: 45
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The adenine base editor (ABE), capable of catalyzing A•T to G•C conversions, is an important gene editing toolbox. Here, we systematically evaluate genome-wide off-target deamination by ABEs using the EndoV-seq platform we developed. EndoV-seq utilizes Endonuclease V to nick the inosine-containing DNA strand of genomic DNA deaminated by ABE in vitro. The treated DNA is then whole-genome sequenced to identify off-target sites. Of the eight gRNAs we tested with ABE, 2–19 (with an average of 8.0) o...
#1Mafei Xu (BCM: Baylor College of Medicine)H-Index: 4
#2Jun Qin (CAS: Chinese Academy of Sciences)
Last.Sophia Y. Tsai (BCM: Baylor College of Medicine)H-Index: 76
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Alternative lengthening of telomeres (ALT) is known to use homologous recombination (HR) to replicate telomeric DNA in a telomerase-independent manner. However, the detailed process remains largely undefined. It was reported that nuclear receptors COUP-TFII and TR4 are recruited to the enriched GGGTCA variant repeats embedded within ALT telomeres, implicating nuclear receptors in regulating ALT activity. Here, we identified a function of nuclear receptors in ALT telomere maintenance that involve...
#1Feng Li (SYSU: Sun Yat-sen University)H-Index: 6
#2Yuanlong Ge (SYSU: Sun Yat-sen University)H-Index: 5
Last.Zhou Songyang (SYSU: Sun Yat-sen University)H-Index: 45
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Pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs), ESCs derived by somatic cell nuclear transfer (ntESCs), and induced pluripotent stem cells (iPSCs) have unlimited capacity for self-renewal and pluripotency and can give rise to all types of somatic cells. In order to maintain their self-renewal and pluripotency, PSCs need to preserve their telomere length and homeostasis. In recent years, increasing studies have shown that telomere reprogramming is essential for stem cell plurip...
#1Jianxi Zhu (SYSU: Sun Yat-sen University)
#2Mingyang Xu (SYSU: Sun Yat-sen University)
Last.Zhou Songyang (SYSU: Sun Yat-sen University)H-Index: 45
view all 9 authors...
#1Zhuoheng Lin (SYSU: Sun Yat-sen University)H-Index: 3
#2Puping Liang (SYSU: Sun Yat-sen University)H-Index: 8
Last.Junjiu HuangH-Index: 19
view all 15 authors...
Abstract Mammalian spermatogenesis is maintained by a rare population of spermatogonial stem cells (SSCs), which are important for male fertility. SSCs remain a subset of undifferentiated spermatogonia, which can be isolated by a combination of surface markers. Specific markers to identify and isolate undifferentiated spermatogonia are lacking. Ussp1, a transcript previously annotated as long noncoding RNA (RIKEN cDNA 4933427D06, Gene ID: 232217), virtually encodes a membrane protein, USSP1, in ...
#1Zhen Zhang (SYSU: Sun Yat-sen University)H-Index: 4
#2Tao Wan (ZJU: Zhejiang University)H-Index: 2
Last.Junjiu Huang (SYSU: Sun Yat-sen University)H-Index: 19
view all 12 authors...
#1Tingting Deng (SYSU: Sun Yat-sen University)H-Index: 3
#2Yan Huang (SYSU: Sun Yat-sen University)H-Index: 28
Last.Zhou Songyang (SYSU: Sun Yat-sen University)H-Index: 45
view all 11 authors...