Nucleic Acids Research
Papers 10000
1 page of 1,000 pages (10k results)
#1Annabelle Biscans (UMMS: University of Massachusetts Medical School)H-Index: 6
#2Jillian Caiazzi (UMMS: University of Massachusetts Medical School)
Last. Anastasia Khvorova (UMMS: University of Massachusetts Medical School)H-Index: 37
view all 6 authors...
Small interfering RNAs (siRNAs) have revolutionized the treatment of liver diseases. However, robust siRNA delivery to other tissues represents a major technological need. Conjugating lipids (e.g. docosanoic acid, DCA) to siRNA supports extrahepatic delivery, but tissue accumulation and gene silencing efficacy are lower than that achieved in liver by clinical-stage compounds. The chemical structure of conjugated siRNA may significantly impact invivo efficacy, particularly in tissues with lower c...
#1Hannah M. Wüst (FAU: University of Erlangen-Nuremberg)H-Index: 1
#2Amélie Wegener (FAU: University of Erlangen-Nuremberg)H-Index: 2
Last. Michael Wegner (FAU: University of Erlangen-Nuremberg)H-Index: 70
view all 11 authors...
Schwann cells are the nerve ensheathing cells of the peripheral nervous system. Absence, loss and malfunction of Schwann cells or their myelin sheaths lead to peripheral neuropathies such as Charcot-Marie-Tooth disease in humans. During Schwann cell development and myelination chromatin is dramatically modified. However, impact and functional relevance of these modifications are poorly understood. Here, we analyzed histone H2B monoubiquitination as one such chromatin modification by conditionall...
#1Jinzhong Tian (CAS: Chinese Academy of Sciences)H-Index: 3
#2Gaohua Yang (CAS: Chinese Academy of Sciences)H-Index: 3
Last. Weihong Jiang (CAS: Chinese Academy of Sciences)H-Index: 26
view all 6 authors...
Quorum-sensing (QS) mediated dynamic regulation has emerged as an effective strategy for optimizing product titers in microbes. However, these QS-based circuits are often created on heterologous systems and require careful tuning via a tedious testing/optimization process. This hampers their application in industrial microbes. Here, we design a novel QS circuit by directly integrating an endogenous QS system with CRISPRi (named EQCi) in the industrial rapamycin-producing strain Streptomyces rapa...
#1Byungkuk MinH-Index: 4
#2Jung Sun ParkH-Index: 20
Last. Yong-Kook Kang (UST: Korea University of Science and Technology)
view all 5 authors...
Genome-wide passive DNA demethylation in cleavage-stage mouse embryos is related to the cytoplasmic localization of the maintenance methyltransferase DNMT1. However, recent studies provided evidences of the nuclear localization of DNMT1 and its contribution to the maintenance of methylation levels of imprinted regions and other genomic loci in early embryos. Using the DNA adenine methylase identification method, we identified Dnmt1-binding regions in four- and eight-cell embryos. The unbiased di...
#1Anita Donlic (Duke University)H-Index: 3
#2Martina Zafferani (Duke University)
Last. Amanda E. Hargrove (Duke University)H-Index: 16
view all 5 authors...
Small molecule-based modulation of a triple helix in the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been proposed as an attractive avenue for cancer treatment and a model system for understanding small molecule:RNA recognition. To elucidate fundamental recognition principles and structure-function relationships, we designed and synthesized nine novel analogs of a diphenylfuran-based small molecule DPFp8, a previously identified lead binder of MALAT1. ...
#1Lisa Aberle (University of Konstanz)
#2Annika Krüger (University of Konstanz)H-Index: 4
Last. Karina Schütz (University of Konstanz)
view all 15 authors...
Poly(ADP-ribosyl)ation regulates numerous cellular processes like genome maintenance and cell death, thus providing protective functions but also contributing to several pathological conditions. Poly(ADP-ribose) (PAR) molecules exhibit a remarkable heterogeneity in chain lengths and branching frequencies, but the biological significance of this is basically unknown. To unravel structure-specific functions of PAR, we used PARP1 mutants producing PAR of different qualities, i.e. short and hypobran...
#1Renbin Lu (CSU: Central South University)
#2Yufan Dong (CSU: Central South University)
Last. Jia-Da Li (CSU: Central South University)H-Index: 1
view all 3 authors...
Circadian clocks are endogenous oscillators that control ∼24-hour physiology and behaviors in virtually all organisms. The circadian oscillator comprises interconnected transcriptional and translational feedback loops, but also requires finely coordinated protein homeostasis including protein degradation and maturation. However, the mechanisms underlying the mammalian clock protein maturation is largely unknown. In this study, we demonstrate that necdin, one of the Prader-Willi syndrome (PWS)-ca...
#1Bidossessi Wilfried Hounkpe (State University of Campinas)H-Index: 2
#2Francine Chenou (State University of Campinas)
Last. Erich Vinicius De Paula (State University of Campinas)H-Index: 16
view all 4 authors...
Housekeeping (HK) genes are constitutively expressed genes that are required for the maintenance of basic cellular functions. Despite their importance in the calibration of gene expression, as well as the understanding of many genomic and evolutionary features, important discrepancies have been observed in studies that previously identified these genes. Here, we present Housekeeping and Reference Transcript Atlas (HRT Atlas v1.0, a web-based database which addresses ...
#1Dipanwita Banerjee (Konan University)
#2Hisae Tateishi-Karimata (Konan University)H-Index: 14
Last. Naoki Sugimoto (Konan University)H-Index: 51
view all 7 authors...
The stability of Watson-Crick paired RNA/DNA hybrids is important for designing optimal oligonucleotides for ASO (Antisense Oligonucleotide) and CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas9 techniques. Previous nearest-neighbour (NN) parameters for predicting hybrid stability in a 1 M NaCl solution, however, may not be applicable for predicting stability at salt concentrations closer to physiological condition (e.g. ∼100 mM Na+ or K+ in the presence or absence of Mg2+)...
#1Hongfang Qiu (NIH: National Institutes of Health)H-Index: 23
#2Emily Biernat (UR: University of Rochester)
Last. Alan G. Hinnebusch (NIH: National Institutes of Health)H-Index: 81
view all 7 authors...
The chromatin remodelers SWI/SNF and RSC function in evicting promoter nucleosomes at highly expressed yeast genes, particularly those activated by transcription factor Gcn4. Ino80 remodeling complex (Ino80C) can establish nucleosome-depleted regions (NDRs) in reconstituted chromatin, and was implicated in removing histone variant H2A.Z from the -1 and +1 nucleosomes flanking NDRs; however, Ino80C's function in transcriptional activation in vivo is not well understood. Analyzing the cohort of Gc...
Top fields of study
Molecular biology