Expression of IGF/insulin receptor in prostate cancer tissue and progression to lethal disease
Abstract
Circulating insulin-like growth factor-1 (IGF-1) is consistently associated with prostate cancer risk. IGF-1 binds to IGF-1 receptor (IGF1R) and insulin receptor (IR), activating cancer hallmark pathways. Experimental evidence suggests that TMPRSS2:ERG may interact with IGF/insulin signaling to influence progression. We investigated IGF1R and IR expression and its association with lethal prostate cancer among 769 men. Protein expression of...
Paper Details
Title
Expression of IGF/insulin receptor in prostate cancer tissue and progression to lethal disease
Published Date
Aug 24, 2018
Journal
Volume
39
Issue
12
Pages
1431 - 1437
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