Metabolically activated and classically activated pro-inflammatory M1 macrophages exhibit divergent effects on ABCA1 cholesterol efflux capacity

Aim: Pro-inflammatory M1 macrophages exhibit differential expression of plasma membrane proteins depending upon their micro-environment. In this study we questioned how macrophage cholesterol efflux capacity is affected under classically inflamed (LPS+IFNg) (MM1) versus metabolically activated (high glucose, palmitate and insulin) (MMe)...