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#1Hiroyuki JinnouchiH-Index: 4
#2Yu SatoH-Index: 3
Last. Aloke V. FinnH-Index: 36
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Abstract Atherosclerotic lesion progression is associated with intimal calcification. The earliest lesion that shows calcification is pathologic intimal thickening in which calcifications appear as microcalcifications that vary in size from 15 μm to 1 mm in diameter), fragmented (>1 mm), and eventually sheet-like calcification (>3 mm). When stratified by plaque type, maximum calcifications are observed in fibrocalcific plaques, followed by healed plaque ruptures. Lesions of acute thrombi, i.e., ...
#1Anna Staudt (Innsbruck Medical University)H-Index: 1
#2Katharina Stock (Innsbruck Medical University)H-Index: 2
Last. Markus Anliker (Innsbruck Medical University)H-Index: 3
view all 23 authors...
Abstract Background and aims Atherosclerosis starts early in life. We aimed to assess the dimension and progression of the intima-media thickness, a surrogate marker for early vascular aging, and its association with a broad palette of cardiovascular risk and lifestyle factors in a large cohort of healthy adolescents. Methods The EVA-Tyrol cohort study enrolled 1573 adolescents with a mean age of 16.0 years (SD 0.9). 1000 participants had a prospective follow-up after 22.1 months on average (SD ...
#1Henry NordingH-Index: 3
Last. Harald F. LangerH-Index: 40
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Abstract Cardiovascular disease remains the main cause of death worldwide. For this reason, strategies for the primary prevention of atherosclerosis and atherosclerosis-related pathologies like stroke or myocardial infarction are needed. Platelets are key players of atherosclerosis-related vascular thrombotic pathologies and their role as targets in secondary prevention of atherosclerosis-related complications is uncontested. However, platelets also play an important role in the initiation and p...
#1Kajus Baidžajevas (University of Sheffield)H-Index: 1
#2Eva Hadadi (University of Sheffield)H-Index: 7
Last. Heather Wilson (University of Sheffield)H-Index: 25
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Abstract Background and aims Lipid-rich foam cell macrophages drive atherosclerosis via several mechanisms, including inflammation, lipid uptake, lipid deposition and plaque vulnerability. The atheroma environment shapes macrophage function and phenotype; anti-inflammatory macrophages improve plaque stability while pro-inflammatory macrophages promote rupture. Current evidence suggests a variety of macrophage phenotypes occur in atherosclerotic plaques with local lipids, cytokines, oxidised phos...
#1Gian Paolo Fadini (UNIPD: University of Padua)H-Index: 47
#2Marcello Rattazzi (UNIPD: University of Padua)H-Index: 19
Last. Bo YuH-Index: 15
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Abstract Background and aims Ceramides (Cer) are an atherogenic substance. However, the associations between specific plasma Cer levels and culprit plaque morphology in ST-segment elevation myocardial infarction (STEMI) patients are unclear. Methods The study consisted of two parallel cohorts. 100 consecutive patients with STEMI were screened as discovery cohort. In the validation cohort, we separately screened 30 normal donors, 30 stable angina pectoris (SAP) and 315 STEMI patients. All STEMI p...
#2Chandana ShekarH-Index: 1
Last. Chris DailingH-Index: 2
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Abstract Background and aims Endothelial dysfunction and atherosclerosis are linked by multiple mechanisms. Brachial artery flow-mediated dilation (FMD) rate is used to evaluate endothelial function and has been independently associated with adverse cardiac outcomes. The relationship between brachial artery FMD rate and severity of subclinical atherosclerosis by coronary computed tomography angiography (CCTA) is not understood. We hypothesized that brachial FMD is inversely associated with burde...
#1Koki Nakanishi (UTokyo: University of Tokyo)H-Index: 1
#1Koki NakanishiH-Index: 12
Last. Hiroyuki MoritaH-Index: 36
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Abstract Background and aims Although carotid intima-media thickness (IMT) is an established marker of atherosclerosis and carries independent risk for cardiovascular disease, its possible association with subclinical cardiac dysfunction has not been extensively evaluated. Left ventricular global longitudinal strain (LVGLS) and peak left atrial longitudinal systolic strain (PALS) can detect subclinical left heart dysfunction. This study aimed to investigate the association between carotid IMT an...
#1Takumi Toya (National Defense Medical College)H-Index: 4
#2Michel T. Corban (Mayo Clinic)H-Index: 9
Last. Amir Lerman (Mayo Clinic)H-Index: 92
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Abstract Background and aims Perivascular epicardial adipose tissue (pEAT) plays a key role in the progression of atherosclerosis, plaque rupture, and thrombosis. However, the relationship between pEAT and prognosis after revascularization of ST-segment elevation myocardial infarction (STEMI) is unknown. This study aimed to investigate the relationship between pEAT thickness and prognosis after STEMI. Methods We studied 180 STEMI patients (mean age 59.4 ± 13.3 years, 78.9% male) who underwent ca...
#1Rutao Wang (Fourth Military Medical University)H-Index: 1
#2Kuniaki Takahashi (UvA: University of Amsterdam)H-Index: 4
Last. Hironori Hara (National University of Ireland, Galway)
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Abstract Background and aims The prognostic impact of pre-procedure heart rate (PHR) following percutaneous coronary intervention (PCI) has not yet been fully investigated. This post-hoc analysis sought to assess the impact of PHR on medium-term outcomes among patients having PCI, who were enrolled in the “all-comers” GLOBAL LEADERS trial. Methods and results The primary endpoint (composite of all-cause death or new Q-wave myocardial infarction [MI]) and key secondary safety endpoint (bleeding a...
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