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Atherosclerosis
IF
4.25
Papers
25454
Papers 26232
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Abstract Background and aims Patients with rheumatic diseases have an increased risk of atherosclerosis with up-regulated serum amyloid A (SAA), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), which were reported to activate human coronary artery endothelial cells (HCAEC). We aimed to investigate the effects of TNF-α inhibitor infliximab and anti-infliximab antibodies on the TNF-α/IL-1β/SAA activated HCAEC. Methods HCAEC were incubated with TNF-α, IL-1β, SAA, infliximab, anti-inflixi...
#1Allison L. Kuipers (University of Pittsburgh)H-Index: 9
#2Mary K. Wojczynski (WashU: Washington University in St. Louis)H-Index: 22
Last.Michael A. Province (WashU: Washington University in St. Louis)H-Index: 78
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Abstract Background and aims Atherosclerosis develops with age and is partially controlled by genetics. Research to date has identified common variants with small effects on atherosclerosis related traits. We aimed to use family-based genome-wide linkage analysis to identify chromosomal regions potentially harboring rare variants with larger effects for atherosclerosis related traits. Methods Participants included 2205 individuals from the Long Life Family Study (LLFS), which recruited families ...
#1Markus AxmannH-Index: 9
#2Witta StroblH-Index: 5
Last.Herbert StanglH-Index: 18
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Abstract Cholesterol homeostasis is of central importance for life. Therefore, cells have developed a divergent set of pathways to meet their cholesterol needs. In this review, we focus on the direct transfer of cholesterol from lipoprotein particles to the cell membrane. More molecular details on the transfer of lipoprotein-derived lipids were gained by recent studies using phospholipid bilayers. While amphiphilic lipids are transferred right after contact of the lipoprotein particle with the m...
#1Katarina D. Kovacevic (Medical University of Vienna)H-Index: 1
#2F.J. Mayer Florian (Medical University of Vienna)H-Index: 3
Last.Matthias Hoke (Medical University of Vienna)H-Index: 12
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Abstract Background Von Willebrand factor (VWF) plays an important role in thrombogenesis and mediates platelet adhesion particularly under high shear stress. Such conditions are generally found in stenotic arteries and can eventually cause myocardial infarction or stroke. Aim To study whether levels of VWF antigen (VWF:Ag) predict future major adverse cardiovascular events (MACE) in patients suffering from carotid artery stenosis. Methods Patients with atherosclerotic carotid artery disease def...
#1Uma Ramaswami (Royal Free London NHS Foundation Trust)H-Index: 4
#2Steve E. Humphries (UCL: University College London)H-Index: 102
Last.Andrew A. M. Morris (University of Manchester)H-Index: 29
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Abstract This consensus statement on the management of children and young people with heterozygous familial hypercholesterolaemia (FH) addresses management of paediatric FH in the UK, identified by cascade testing when a parent is diagnosed with FH and for those diagnosed following incidental lipid tests. Lifestyle and dietary advice appropriate for children with FH; suggested low density lipoprotein cholesterol (LDL-C) targets and the most appropriate lipid-lowering therapies to achieve these a...
#1In-Chang HwangH-Index: 5
#2Heesun LeeH-Index: 1
Last.Goo-Yeong ChoH-Index: 15
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Abstract Background and aims Given the potential benefit of medical therapy in patients with non-obstructive coronary artery disease (CAD), there is a need for risk stratification and treatment strategy for these patients. We aimed to develop a risk prediction model for non-obstructive CAD patients for risk stratification and guidance of statin and aspirin therapy. Methods From a cohort of consecutive patients who underwent coronary computed tomography angiography (CCTA) (n = 25,087), we identif...
#1Ana Leon-AcuñaH-Index: 4
Last.Javier Delgado-Lista (UCO: University of Córdoba (Spain))
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Abstract Background and aims Recent evidence suggests that postprandial hypertriglyceridemia (PPT) is associated with the incidence of CVD. Several non-modifiable factors (genetics, age, gender) and lifestyle factors (physical activity, smoking, regular alcohol) have shown their ability to modulate PPT. We evaluate the influence of regular alcohol intake, physical activity and smoking habit modulating PPT in the CORDIOPREV study (NCT00924937). Methods 1002 patients were subject to an oral fat lo...
Abstract Background and aims Cholesterol treatment for the primary prevention of cardiovascular disease is based on cardiovascular risk, as assessed by the SCORE (Systematic COronary Risk Evaluation) scale. This study aimed to assess the predictive value and clinical utility of the SCORE scale for preventing cardiovascular events and all-cause mortality in people with dyslipidemia and no lipid-lowering treatment. Methods Patients with dyslipidemia and no lipid-lowering treatment were included fr...
#1Jing Zhang (CTGU: China Three Gorges University)H-Index: 3
#2W. Cai (CTGU: China Three Gorges University)H-Index: 1
Last.Jian Yang (CTGU: China Three Gorges University)H-Index: 11
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Abstract Background and aims The process of endothelial repair in diabetic patients after stent implantation was significantly delayed compared with that in non-diabetic patients, and oxidative stress is increasingly considered to be relevant to the pathogenesis of diabetic endothelial repair. However, the mechanisms linking diabetes to reendothelialization after vascular injury have not been fully elucidated. The aim of this study was to evaluate the effect of microRNA-24 (miR-24) up-regulation...
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