Papers 26318
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#1Cheng Yang Hsieh (NCKU: National Cheng Kung University)H-Index: 1
#2Hsieh Cheng-Yang (NCKU: National Cheng Kung University)
Last.Sheng-Feng Sung (CCU: National Chung Cheng University)
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Abstract Background and aims Prompt detection of atrial fibrillation (AF) is essential for optimal secondary stroke prevention, but routine long-term cardiac monitoring of all ischemic stroke patients is neither practical nor affordable. We aimed to develop and validate a risk score to identify patients at risk for newly diagnosed AF (NDAF) after ischemic stroke. Methods Information on adult patients hospitalized for ischemic stroke without known AF was retrieved from a nationwide database. Prim...
#1Mohammadhassan Mirbolouk (Yale University)H-Index: 8
#2Sina Kianoush (Yale University)H-Index: 10
Last.Michael J. Blaha (Johns Hopkins University)H-Index: 52
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Abstract Background and aims Cardiovascular disease (CVD) and cancer are the two leading causes of death in smokers. Lung cancer screening is recommended in a large proportion of smokers. We examined the implication of coronary artery calcium (CAC) score (quantitative and qualitative) for cardiovascular disease (CVD), coronary heart disease (CHD), and cancer mortality risk prediction among current smokers. Methods We included current smokers without known heart disease from the CAC Consortium. C...
#2M. ChiesaH-Index: 3
Last.Gianluca PontoneH-Index: 33
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Abstract Background and aims Artificial intelligence (AI) is increasing its role in diagnosis of patients with suspicious coronary artery disease. The aim of this manuscript is to develop a deep convolutional neural network (CNN) to classify coronary computed tomography angiography (CCTA) in the correct Coronary Artery Disease Reporting and Data System (CAD-RADS) category. Methods Two hundred eighty eight patients who underwent clinically indicated CCTA were included in this single-center retros...
#1Lars Lind (Uppsala University)H-Index: 98
#2Bruna Gigante (KI: Karolinska Institutet)H-Index: 41
Last.Gunnar Engström (Lund University)H-Index: 58
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Abstract Background and aims Genetic loci associated with CHD show different relationships with the intima-media thickness in the common carotid artery (IMT-CCA) and in the bulb (IMT-bulb). We evaluated if IMT-CCA and IMT-bulb differ also with respect to circulating protein profiles and risk of incident atherosclerotic disease. Methods In three Swedish cohorts (MDC, IMPROVE, PIVUS, total n > 7,000), IMT-CCA and IMT-bulb were assessed by ultrasound at baseline and 86 cardiovascular-related protei...
#1Pauli Ohukainen (University of Oulu)H-Index: 6
#2Sanna KuusistoH-Index: 3
Last.Mika Ala-KorpelaH-Index: 47
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Abstract Background and aims Population subgrouping has been suggested as means to improve coronary heart disease (CHD) risk assessment. Methods We applied here a self-organizing map (SOM) artificial intelligence methodology to define subgroups based on detailed lipoprotein profiles in a population-based cohort (n = 5789) and utilised the trained SOM in an independent cohort (n = 7607). We identified four SOM-based subgroups of individuals with distinct lipoprotein profiles and CHD risk and comp...
#1Kathryn J. Griffin (University of Leeds)H-Index: 8
#2Laura M. Newell (UoB: University of Bristol)
Last.Richard J. Pease (University of Leeds)H-Index: 11
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Abstract Background and aims Transglutaminase (TG) 2 and Factor (F) XIII-A have both been implicated in cardiovascular protection and repair. This study was designed to differentiate between two competing hypotheses: that TG2 and FXIII-A mediate these functions in mice by fulfilling separate roles, or that they act redundantly in this respect. Methods Atherosclerosis was assessed in brachiocephalic artery plaques of fat-fed mixed strain apolipoprotein (Apo)e deficient mice that lacked either or ...
#1Uta Ceglarek (Leipzig University)H-Index: 27
#2Julia Dittrich (Leipzig University)H-Index: 4
Last.Gabriela Aust (Leipzig University)H-Index: 30
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Abstract Background and aims Circulating sterols result either from cholesterol (CH) synthesis or intestinal uptake. They are mainly esterified and can be oxygenated. Sterols accumulate in atherosclerotic plaques whereby their clinical impact is uncertain. Here, we determined associations between circulating and plaque sterol levels in patients with advanced carotid artery stenosis in respect to a prior ischemic event and statin treatment. Methods Free and esterified CH, CH precursors and plant ...
#1Alison Pottle (Harefield Hospital)H-Index: 7
#2Gilbert R. Thompson (Imperial College London)H-Index: 48
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#1Zhan WangH-Index: 1
#2Russel C. SequeiraH-Index: 2
Last.Xuewei Zhu (Wake Forest University)H-Index: 19
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Abstract Background and aims Dietary long-chain (≥20 carbons) n-3 polyunsaturated fatty acids (PUFAs) reduce atherosclerosis and enhance macrophage autophagy activation. How macrophage autophagy impacts atherosclerotic progression, particularly when comparing dietary n-3 PUFA supplementation vs. saturated fat feeding, is unknown. Methods We generated myeloid-specific autophagy-deficient and control mice in the Ldlr−/− background by transplanting bone marrow from myeloid-specific autophagy-relate...
#1Didac Jerez-Dolz (University of Barcelona)H-Index: 1
#2Sergi Torramade-Moix (University of Barcelona)H-Index: 1
Last.Gines Escolar (University of Barcelona)
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Abstract Background and aims Circulating platelet microparticles (PMP) are the most abundant in bloodstream, are highly procoagulant and contribute to cross-talk with inflammatory cells. The aim of the present study was to investigate the interactions of PMP with platelets and explore the involvement of toll-like receptor 4 (TLR-4). Methods PMP were separated by ultracentrifugation of expired platelet concentrates and added to: i) washed platelets, to confirm uptake, by flow cytometry and confoc...
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Diabetes mellitus