Papers 26371
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#1Ji-Won KimH-Index: 8
#2Hee Jeong JangH-Index: 1
Last. Ick Chan KwonH-Index: 86
view all 14 authors...
Abstract Background and aims Exercise training (ET) helps treat atherosclerosis. However, many patients stop regular ET for various reasons. The effect of detraining on atherosclerosis is not well studied. We examined the effects of ET vs. short-term detraining on atheromatous matrix-metalloproteinase (MMP) activity in preexisting plaque and circulating cytokines/lipids. Methods and results Eighteen-week-old apolipoprotein-E−/− mice (n = 56) on a Western-diet underwent: 1) ET for 6-weeks (ET5+1)...
#1Yan Liu (Qingdao University)
#2Yanyan Yang (Qingdao University)H-Index: 5
Last. Kun Wang (Qingdao University)H-Index: 17
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Abstract Angiogenesis is the physiological process of new blood vessel formation from existing capillary vessel or posterior capillary vein. Its dysfunction could result in a number of different kinds of diseases, such as cardiovascular diseases and cancer, contributing to death and disability worldwide. Circular RNAs (circRNAs) are a class of novel identified RNA molecules that have a special covalent loop structure without a 5′ cap and 3’ tail, which can form novel back-splicing or skipping ev...
#1Ding Ding (SYSU: Sun Yat-sen University)H-Index: 26
#2Qing-wei Zhong (SYSU: Sun Yat-sen University)
Last. Yu-ming Chen (SYSU: Sun Yat-sen University)H-Index: 28
view all 7 authors...
Abstract Background and aims The relationship of polyunsaturated fatty acids (PUFAs) with cardiovascular risk is still controversial. We aimed to determine whether erythrocyte n-3 and n-6 PUFAs are related to the risk of carotid atherosclerosis. Methods From 2008 to 2019, baseline erythrocyte n-3 and n-6 PUFAs were determined in a cohort of 4040 Chinese adults (40–75 ys). The intima-media thickness (IMT) at the common carotid artery (CCA) and bifurcation of the carotid artery (BIF) and carotid p...
#1Qi Wang (Qingdao University)
#1Qi WangH-Index: 2
Last. Tao YuH-Index: 6
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Abstract Background and aims The endothelium is crucially involved in the pathogenesis of atherosclerosis according to accumulating evidence. Moreover, recent studies have showed that lncRNAs could serve as biomarkers of cardiovascular diseases, in particular atherosclerosis. However, the underlying mechanism of endothelial dysfunction involving lncRNAs in atherosclerosis remains unknown. This study investigated the mechanism of lncRNA XXYLT1-AS2 in endothelial dysfunction in atherosclerosis. Me...
#1Oliver Königsbrügge (Medical University of Vienna)H-Index: 11
#2Sabine SchmaldienstH-Index: 17
Last. Manfred Hecking (Medical University of Vienna)H-Index: 21
view all 14 authors...
Abstract Background and aims Cardiovascular disease (CVD) is common in patients with end-stage renal disease (ESRD) on hemodialysis (HD). However, antithrombotic therapy to prevent CVD increases the risk of bleeding. We aimed to investigate the prevalence of CVD and the practice patterns of antithrombotic agents in patients with ESRD on HD. Methods In a cross-sectional population based cohort of chronic HD patients (n = 626) from Vienna, Austria, the medical histories of patients and use of anti...
#1Xiangdong WuH-Index: 5
#2Keyang ChenH-Index: 6
Last. Kevin Jon WilliamsH-Index: 56
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Abstract Background and aims Patients with overnutrition, obesity, the atherometabolic syndrome, and type 2 diabetes typically develop fatty liver, atherogenic dyslipoproteinemia, hyperglycemia, and hypertension. These features share an unexplained origin – namely, imbalanced insulin action, also called pathway-selective insulin resistance and responsiveness. To control glycemia, these patients require hyperinsulinemia that then overdrives ERK and hepatic de-novo lipogenesis. We previously repor...
#1Christoph J. BinderH-Index: 47
#2Jan BorénH-Index: 64
Last. A. von EckardsteinH-Index: 73
view all 9 authors...
Abstract Cardiovascular complications due to accelerated atherosclerosis and arterial stiffening are the leading cause of morbidity and mortality in the Western society. Both pathologies are frequently associated with vascular calcification. Deposits of calcium phosphate salts, mainly in form of hydroxyapatite, is the hallmark of vascular calcification. Calcification is frequently observed in atherosclerotic lesions (intimal calcification), associated with vascular smooth muscle cells (VSMCs) an...
#1Nels C. Olson (UVM: University of Vermont)H-Index: 11
#2Colleen M. Sitlani (UW: University of Washington)H-Index: 18
Last. Joseph A. Delaney (UM: University of Manitoba)H-Index: 30
view all 8 authors...
Abstract Background and aims Cell-mediated immunity is implicated in atherosclerosis. We evaluated whether innate and adaptive immune cell subsets in peripheral blood are risk factors for coronary heart disease. Methods A nested case-cohort study (n = 2,155) was performed within the Multi-Ethnic Study of Atherosclerosis (MESA) and the Cardiovascular Health Study (CHS). Cases of incident myocardial infarction (MI) and incident angina (n = 880 total cases) were compared with a cohort random sample...
#1Bradley Tucker (UNSW: University of New South Wales)H-Index: 1
#2Robyn L. McClelland (UW: University of Washington)H-Index: 64
Last. Kwok Leung Ong (UNSW: University of New South Wales)H-Index: 26
view all 8 authors...
Abstract Background and aims Non-alcoholic fatty liver disease (NAFLD) is associated with inflammation and atherogenic lipoprotein abnormalities. Previous studies suggest an association of fibroblast growth factor 21 (FGF21) with NAFLD. Therefore, we assessed the association of circulating FGF21 levels with inflammatory markers, lipoprotein profile and NAFLD in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods Among 6814 participants free of apparent cardiovascular disease at baseline (2...
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Diabetes mellitus