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Fiona C. McGillicuddy
University College Dublin
59Publications
19H-index
1,818Citations
Publications 59
Newest
#1Robyn Bruen (UCD: University College Dublin)H-Index: 2
#2Sean Curley (UCD: University College Dublin)H-Index: 1
Last.Orina Belton (UCD: University College Dublin)H-Index: 18
view all 10 authors...
Monocytes/macrophages drive progression and regression of atherosclerosis. Conjugated linoleic acid (CLA), an anti-inflammatory lipid, mediates atheroprotective effects. We investigated how CLA alt...
#1Robyn Bruen (UCD: University College Dublin)H-Index: 2
#2Sean Curley (UCD: University College Dublin)H-Index: 1
Last.Orina Belton (UCD: University College Dublin)H-Index: 18
view all 11 authors...
We have shown that the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide (Lir) inhibits development of early atherosclerosis in vivo by modulating immune cell function. We hypothesized that Lir could attenuate pre-established disease by modulating monocyte or macrophage phenotype to induce atheroprotective responses. Human atherosclerotic plaques obtained postendarterectomy and human peripheral blood macrophages were treated ex vivo with Lir. In parallel, apolipoprotein E–deficient ...
#1M. O'Reilly (UCD: University College Dublin)H-Index: 4
#2Sarina Kajani (UCD: University College Dublin)H-Index: 1
Last.Fiona C. McGillicuddy (UCD: University College Dublin)H-Index: 19
view all 6 authors...
#1Domenico Sergi (Aberd.: University of Aberdeen)H-Index: 4
#2Fiona M. Campbell (Aberd.: University of Aberdeen)H-Index: 3
Last.Lynda M. Williams (Aberd.: University of Aberdeen)H-Index: 23
view all 24 authors...
Energy homeostasis is regulated by the hypothalamus but fails when animals are fed a high-fat diet (HFD), and leptin insensitivity and obesity develops. To elucidate the possible mechanisms underlying these effects, a microarray-based transcriptomics approach was used to identify novel genes regulated by HFD and leptin in the mouse hypothalamus. Mouse global array data identified serpinA3N as a novel gene highly upregulated by both a HFD and leptin challenge. In situ hybridisation showed serpinA...
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