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Fiona C. McGillicuddy
University College Dublin
EndocrinologyAdipose tissueInflammationInsulin resistanceDiabetes mellitus
59Publications
19H-index
1,818Citations
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Publications 64
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#1Jessica C. Ralston (UCD: University College Dublin)H-Index: 8
#2K.A.J. Mitchelson (UCD: University College Dublin)
Last. Fiona C. McGillicuddy (UCD: University College Dublin)H-Index: 19
view all 13 authors...
SCOPE IL-1RI-mediated inflammatory signaling alters metabolic tissue responses to dietary challenges (e.g. high-fat diet (HFD)). Recent work suggests that metabolic phenotype is transferrable between mice in a shared living environment (i.e. co-housing) due to gut microbiome exchange. We examined whether the metabolic phenotype of IL-1RI-/- mice fed HFD or low-fat diet (LFD) could be transferred to wildtype (WT) mice through gut microbiome exchange facilitated by co-housing. METHODS AND RESULTS ...
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Preliminary evidence suggested that high-fat diets (HFD) enriched with saturated fatty acids (SFA) but not monounsaturated fatty acids (MUFA), promoted hyperinsulinemia and pancreatic hypertrophy with insulin resistance. The objective of this study was to determine whether substitution of dietary MUFA within a HFD could attenuate the progression of pancreatic islet dysfunction seen with prolonged SFA-HFD. For 32 weeks, C57BL/6J mice were fed either: 1) low fat diet, 2) SFA-HFD, or 3) SFA-HFD for...
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#1M. O'Reilly (UCD: University College Dublin)H-Index: 4
#2Y.M. Lenighan (UCD: University College Dublin)H-Index: 3
Last. Fiona C. McGillicuddy (UCD: University College Dublin)H-Index: 19
view all 11 authors...
SCOPE: High-fat diet (HFD)-induced obesity impairs macrophage-to-feces reverse cholesterol transport (RCT). It is hypothesized that dietary supplementation with the polyunsaturated fatty acids conjugated linoleic acid (CLA) or alpha linolenic acid (ALA) would prevent HFD-impaired RCT by modulating hepatic protein pathways. METHODS AND RESULTS: ApoE3L.CETP mice are fed a HFD supplemented +/- CLA or ALA for 12 weeks and in vivo macrophage-to-feces RCT is determined. Hepatic cholesterol transporter...
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#1Jessica C. RalstonH-Index: 8
Last. Helen M. RocheH-Index: 53
view all 10 authors...
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#1Robyn Bruen (UCD: University College Dublin)H-Index: 2
#2Sean Curley (UCD: University College Dublin)H-Index: 1
Last. Orina Belton (UCD: University College Dublin)H-Index: 18
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We have shown that the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide (Lir) inhibits development of early atherosclerosis in vivo by modulating immune cell function. We hypothesized that Lir could attenuate pre-established disease by modulating monocyte or macrophage phenotype to induce atheroprotective responses. Human atherosclerotic plaques obtained postendarterectomy and human peripheral blood macrophages were treated ex vivo with Lir. In parallel, apolipoprotein E–deficient ...
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#1Sean CurleyH-Index: 1
#2Eugene T. DillonH-Index: 7
Last. Fiona C. McGillicuddyH-Index: 19
view all 4 authors...
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#1Robyn Bruen (UCD: University College Dublin)H-Index: 2
#2Sean Curley (UCD: University College Dublin)H-Index: 1
Last. Orina Belton (UCD: University College Dublin)H-Index: 18
view all 10 authors...
Monocytes/macrophages drive progression and regression of atherosclerosis. Conjugated linoleic acid (CLA), an anti-inflammatory lipid, mediates atheroprotective effects. We investigated how CLA alt...
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#1M. O'Reilly (UCD: University College Dublin)H-Index: 4
#2Sarina Kajani (UCD: University College Dublin)H-Index: 1
Last. Fiona C. McGillicuddy (UCD: University College Dublin)H-Index: 19
view all 6 authors...
BACKGROUND: Cholesterol retention within plasma membranes of macrophages is associated with increased inflammatory signaling. Cholesterol efflux via the transporters ABCA1, ABCG1, and SR-BI to high-density lipoprotein (HDL) particles is a critical mechanism to maintain cellular cholesterol homeostasis. Little is known about the impact of the obese microenvironment on cholesterol efflux capacity (CEC) of macrophages. In this study, the CEC of obese-derived primary adipose-tissue macrophages (ATM)...
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#1Y.M. LenighanH-Index: 3
#2M. O'ReillyH-Index: 4
Last. Helen M. RocheH-Index: 53
view all 10 authors...
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