Original paper
Transcriptomic integration of D4R and MOR signaling in the rat caudate putamen
Abstract
Morphine binding to opioid receptors, mainly to μ opioid receptor (MOR), induces alterations in intracellular pathways essential to the initial development of addiction. The activation of the dopamine D4 receptor (D4R), which is expressed in the caudate putamen (CPu), mainly counteracts morphine-induced alterations in several molecular networks. These involve transcription factors, adaptive changes of MOR signaling, activation of the...
Paper Details
Title
Transcriptomic integration of D4R and MOR signaling in the rat caudate putamen
Published Date
May 9, 2018
Journal
Volume
8
Issue
1
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Notes
History