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The genus Cordyceps : An extensive review of its traditional uses, phytochemistry and pharmacology

Published on Sep 1, 2018in Fitoterapia 2.43
· DOI :10.1016/j.fitote.2018.05.010
Opeyemi Joshua Olatunji3
Estimated H-index: 3
(PSU: Prince of Songkla University),
Jian Tang4
Estimated H-index: 4
(Jiangsu University)
+ 3 AuthorsZhen Ouyang5
Estimated H-index: 5
(Jiangsu University)
Cite
Abstract
Abstract The genus Cordyceps has about 750 identified species which are distributed in many regions of the World, but mainly found in South Asia, Europe and North America. The species of the genus are highly priced and are widely used as food and medicine for the treatment of various ailments. This present review compiles literature information on the ethno-medicinal, phytochemistry and pharmacological properties of species in the genus Cordycep s. In addition, the review also suggest recommendations for the future researches. Thirty five Cordyceps species have been reported in the literature to have medicinal properties or has a report on the isolation of bioactive compounds. In vitro and in vivo research studies reporting the validation of the medicinal properties of some species were also reviewed. The phytochemical diversity of this genus was demonstrated with over 200 metabolites including nucleosides, sterols, cyclic peptides, flavonoids, dihydrobenzofurans, bioxanthracenes, polyketide, terpenes, alkaloids and phenolics isolated from various Cordyceps species. Cordyceps sinensis was identified as the most frequently used and most explored member of the Cordyceps genus. Cyclodepsipeptides, nucleosides and polysaccharides were identified as the most studied class of compounds from the genus and they show immunomodulatory, antioxidant, antitumor, cytotoxic, anti-inflammatory, anti-allergic, antidiabetic, analgesic, anti-HIV, antibacterial, antimalarial and antifungal activities. Thus, species belonging to the genus Cordyceps showcases an important source of treating various disorders due to the presence of bioactive constituents that displays potent bioactivities and could serve as possible leads in drug discovery.
  • References (191)
  • Citations (1)
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References191
Newest
Published on Dec 1, 2017in Phytochemistry Letters 1.34
Hsun-Shuo Chang13
Estimated H-index: 13
(KMU: Kaohsiung Medical University),
Ming-Jen Cheng18
Estimated H-index: 18
+ 5 AuthorsIhshengchen31
Estimated H-index: 31
(KMU: Kaohsiung Medical University)
Abstract Four new amide derivatives, designated as cordycepiamides A–D ( 1 – 4 ), together with 14 known compounds ( 5 – 18 ), were isolated from the EtOAc-soluble fraction of the 95% EtOH extract of long-grain rice fermented with the endophytic fungus C. ninchukispora BCRC 31900, derived from the seeds of medicinal plant Beilschmiedia erythrophloia Hayata. Their structures were elucidated by means of spectroscopic and mass-spectrometric analyses, particularly 1D and 2D NMR spectroscopy as well ...
Published on Oct 2, 2017in Mycology
Wen-ming Cheng1
Estimated H-index: 1
(Anhui Medical University),
Xun Zhang1
Estimated H-index: 1
(Anhui Medical University)
+ 4 AuthorsChun-ru Li1
Estimated H-index: 1
(AAU: Anhui Agricultural University)
ABSTRACTNucleosides and nucleobases are one of the most important indicators of quality control. A sensitive and reliable high performance liquid chromatography-ultraviolet method was applied to analyse 13 nucleosides and nucleobases simultaneously in 15 batches of nine Ophiocordyceps species and its allies in China. Principal component analysis (PCA) and cluster analysis were conducted by SPSS 22.0 software (IBM Corp., Armonk, NY, USA). The 15 samples of Cordyceps were differentiated successful...
Published on Apr 1, 2017in Chinese Herbal Medicines
Jia-hui Wang1
Estimated H-index: 1
(CAS: Chinese Academy of Sciences),
Zhong-liang Zhang1
Estimated H-index: 1
+ 4 AuthorsYue-wei Guo1
Estimated H-index: 1
(CAS: Chinese Academy of Sciences)
Abstract Objective To isolate and identify the chemical constituents from mycelia and spores of the fungus Cordyceps cicadae , respectively. Methods The chemical constituents were isolated and purified by repeated silica gel, Sephadex LH-20, and reversed phase HPLC. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR. Results Nine known sterols such as ergosterol ( 1 ), ergosterol peroxide ( 2 ), 9,11-dehydroergosterol perox...
Published on Dec 1, 2016in Journal of Ethnopharmacology 3.41
Tianqiao Yong4
Estimated H-index: 4
,
Minglong Zhang1
Estimated H-index: 1
+ 6 AuthorsYizhen Xie4
Estimated H-index: 4
Abstract Ethnopharmacological relevance Cordyceps militaris was recorded in the classic traditional Chinese medicine book with the main functions of “protecting liver and enhancing kidney functions”, influencing serum uric acid levels. Aim of study The aim is to investigate the hypouricemic effects and possible mechanism of C. militaris in hyperuricemic mice. Materials and methods A water extract (WECM) was prepared by decocting C. militaris directly at 80 °C in water bath, followed by lyophiliz...
Published on Nov 1, 2016in Carbohydrate Polymers 6.04
Opeyemi J. Olatunji4
Estimated H-index: 4
(Jiangsu University),
Yan Feng3
Estimated H-index: 3
(Jiangsu University)
+ 4 AuthorsZhaoliang Su3
Estimated H-index: 3
(Jiangsu University)
Abstract Two polysaccharides CPA-1 and CPB-2 were isolated purified from Cordyceps cicadae by hot water extraction, ethanol precipitation and purification using anion exchange and gel filtration chromatography. Preliminary structural characterization of CPA-1 and CPB-2 were performed. The protective effect of CPA-1 and CPB-2 against glutamate-induced oxidative toxicity in PC12 cells was analyzed. The results indicated that pretreatment of PC12 cells with CPA-1 and CPB-2 significantly increased c...
Published on Jul 1, 2016in Biomedicine & Pharmacotherapy 3.74
Opeyemi J. Olatunji4
Estimated H-index: 4
(Jiangsu University),
Yan Feng3
Estimated H-index: 3
(Jiangsu University)
+ 3 AuthorsZhaoliang Su3
Estimated H-index: 3
(Jiangsu University)
Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is characterized by degeneration and loss of dopaminergic neurons of the substantia nigra. Increasing evidence has indicated that oxidative stress plays a pivotal role in the pathogenesis of Parkinson’s disease (PD). Therapeutic options that target the antioxidant machinery may have potential in the treatment of PD. Cordycepin, a nucleoside isolated from Cordyceps species displayed potent antioxidant, anti-inflamm...
Published on Jun 1, 2016in Environmental Toxicology and Pharmacology 3.06
Opeyemi J. Olatunji4
Estimated H-index: 4
(Jiangsu University),
Yan Feng3
Estimated H-index: 3
(Jiangsu University)
+ 5 AuthorsXiaofeng Yu2
Estimated H-index: 2
(Jiangsu University)
Abstract Glutamate has been proven to induce oxidative stress through the formation of reactive oxygen species (ROS) and increased calcium overload which results in neuronal injury, development of neurodegenerative diseases and death. Adenosine is one of the bioactive nucleosides found in Cordyceps cicadae and it has displayed several pharmacological activities including neuroprotection. In this study, the protective effects of adenosine from C. cicadae against glutamate-induce oxidative stress ...
Published on Feb 24, 2016in Journal of Agricultural and Food Chemistry 3.57
Ching Peng Chiu3
Estimated H-index: 3
(KMU: Kaohsiung Medical University),
Shan Chi Liu5
Estimated H-index: 5
(PRC: China Medical University (PRC))
+ 7 AuthorsWuYang-Chang46
Estimated H-index: 46
Cordyceps militaris (bei-chong-chaw, northern worm grass) is a precious and edible entomopathogenic fungus, which is widely used in traditional Chinese medicine (TCM) as a general booster for the nervous system, metabolism, and immunity. Saccharides, nucleosides, mannitol, and sterols were isolated from this fungus. The biological activity of C. militaris was attributed to the saccharide and nucleoside contents. In this study, the aqueous methanolic fraction of C. militaris fruiting bodies exhib...
Published on Jan 1, 2016in International Journal of Biological Macromolecules 4.78
Feixiang Xiang1
Estimated H-index: 1
(HUST: Huazhong University of Science and Technology),
Liming Lin1
Estimated H-index: 1
(HUST: Huazhong University of Science and Technology)
+ 1 AuthorsXiangqian Qi1
Estimated H-index: 1
(HUST: Huazhong University of Science and Technology)
Abstract This study was aimed to investigate the antihypertensive effect of a polysaccharide fraction from Cordyceps sinensis on spontaneously hypertensive rats (SHR). The CSP1, one component of Cordyceps sinensis polysaccharides (CSP), was obtained after water extraction, deproteinization, de-colorization and purification with DEAE-cellulose 52. And a more homogeneous component CSP1-2 was obtained using Sepharose CL-6B chromatography. CSP1-2 mainly consisted of mannose, glucose and galactose in...
Published on Oct 1, 2015in Carbohydrate Polymers 6.04
Liqin Wang5
Estimated H-index: 5
(SDAU: Shandong Agricultural University),
Nuo Xu10
Estimated H-index: 10
(SDAU: Shandong Agricultural University)
+ 4 AuthorsLe Jia18
Estimated H-index: 18
(SDAU: Shandong Agricultural University)
Abstract Cordyceps militaris has been artificially cultivated in China, and the great amounts of produced medium residue were discarded after the harvest. The aims of this work were to analyze the structure of the residue polysaccharide (RPS) of C. militaris SU-12, and to investigate the pharmacological effects of RPS on lipid metabolism and oxidative stress. RPS was composed of glucose, arabinose and mannose with a ratio of 62:1.6:1 by gas chromatography analysis, and the Mw (weight-average mol...
Cited By1
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Published on Jul 1, 2019in Journal of Pharmaceutical and Biomedical Analysis 2.98
Wei Jia6
Estimated H-index: 6
(Shaanxi University of Science and Technology),
Lin Shi1
Estimated H-index: 1
(Shaanxi University of Science and Technology)
+ 2 AuthorsXiaogang Chu10
Estimated H-index: 10
(Shaanxi University of Science and Technology)
Abstract Cordyceps sinensis is a traditional Chinese food. A high-throughput screening and quantitative method based on hydrophilic interaction chromatography coupled to quadrupole/Orbitrap high resolution mass spectrometry has been proposed for the joint measurement of nucleosides and their corresponding nucleotides in thirty-two Cordyceps sinensis samples. A total of thirty-two natural samples from six regions were enrolled. A multiple-step analysis strategy, including features extraction, noi...
Caicheng Wang (Fujian Agriculture and Forestry University), Weiwei Zhang (Fujian Agriculture and Forestry University)+ -3 AuthorsXiujuan Ye4
Estimated H-index: 4
(Fujian Agriculture and Forestry University)
Antrodia camphorata, also known as A. cinnamomea, is a precious medicinal basidiomycete fungus endemic to Taiwan. This article summarizes the recent advances in research on the multifarious pharmacological effects of A. camphorata. The mushroom exhibits anticancer activity toward a large variety of cancers including breast, cervical, ovarian, prostate, bladder, colorectal, pancreatic, liver, and lung cancers; melanoma; leukemia; lymphoma; neuroblastoma; and glioblastoma. Other activities encompa...