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Fitoterapia
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#1Zhen-Zhu Zhao (Henan University)H-Index: 1
#2Weisheng Feng (Henan University)H-Index: 2
Last.Ji-Kai Liu (SCUN/SCUEC: South Central University for Nationalities)H-Index: 29
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Abstract Ochracines A-E, five previously undescribed norsesquiterpenes featured by unusual scaffolds biogenetically related to chamigrane, were isolated from the cultures of Steccherinum ochraceum. Ochracines A (1) and B (2) represent the first examples of norsesquiterpenes with an unprecedented 1,2-6,7-diseco-1,8-cyclochamigrane scaffold. Ochracines C-D (3–5) possess an unusual 1,2-6,7-diseco-chamigrane skeleton. Their structures were elucidated by analysis of spectroscopic data. The absolute c...
#1Mengyue Wang (SJTU: Shanghai Jiao Tong University)H-Index: 11
#2Zhi-Bin Zhan (JUTCM: Jiangxi University of Traditional Chinese Medicine)
Last.Xiaobo Li (SJTU: Shanghai Jiao Tong University)H-Index: 12
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Abstract Five new lignans mubiesin A − E (1–5), together with twenty-seven known compounds (6–32), were isolated from the cytotoxicity and anti-inflammation portions of Momordica cochinchinensis seeds which were widely used for various tumors and inflammations. Their structures were elucidated by extensive spectroscopic analyses (HR-MS, UV, CD, IR, 1D-NMR, and 2D-NMR). Their cytotoxic and anti-inflammatory activities were evaluated in vitro. Various lignans and saponins showed the significant ac...
#1Shagufta Perveen (KSU: King Saud University)H-Index: 9
#2Ian H. Sadler (Edin.: University of Edinburgh)H-Index: 17
Last.Stephen C. Fry (Edin.: University of Edinburgh)H-Index: 63
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Abstract Crocosmia × crocosmiiflora (montbretia) flowers yielded four esters (montbresides A–D) of a new sucrose-based tetrasaccharide, 3-O-β- d -glucopyranosyl-4´-O-α- d -rhamnopyranosyl-sucrose [β- d -Glc-(1 → 3)-α- d -Glc-(1↔2)-β- d -Fru-(4 ← 1)-α- d -Rha]. All four possess O-p-coumaroyl residues on C-3 of fructose and C-4 of α-glucose, plus O-acetyl residues on C-2 and C-3 of rhamnose and C-6 of fructose. Montbresides A and B are additionally O-acetylated on C-1 of fructose. The p-coumaroyls...
#1Bo Yu (Liaoning Normal University)H-Index: 9
#2Ruifang Xie (Liaoning Normal University)
Last.Hong Yang (Liaoning Normal University)H-Index: 15
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Abstract Ca2+-activated Cl− channels (CaCCs) wildly exist in many tissues which play an important role in ion transport and excitation conduction, especially fluid secretion and smooth muscle contraction in epithelial tissues. TMEM16A as a classic CaCC expresses in the intestine, and has become a potential target of intestinal physiological and pathological researches and therapeutic drug screening. In this study, we identified trans-δ-viniferin (TVN), a resveratrol dimmer, could inhibit TMEM16A...
#1Yan Chen (SYSU: Sun Yat-sen University)
#2Wencong Yang (SYSU: Sun Yat-sen University)
Last.Zhigang She (SYSU: Sun Yat-sen University)H-Index: 18
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Abstract Five new polyketides, colletotric B (2), 3-hydroxy-5-methoxy-2,4,6-trimethylbenzoic acid (3), colletotric C (4), chaetochromone D (6) and 8-hydroxy-pregaliellalactone B (9), together with four known analogues (1, 5 and 7–8) were isolated from the mangrove endophytic fungus Phoma sp. SYSU-SK-7. Their structures were elucidated by analysis of extensive spectroscopic data and mass spectrometric data. Compounds 1–2 showed strong antimicrobial activity against the P. aeruginosa, MRSA and C. ...
#1Faegheh Farhadi (MUMS: Mashhad University of Medical Sciences)H-Index: 1
#2Javad Asili (MUMS: Mashhad University of Medical Sciences)H-Index: 15
Last.Mehrdad Iranshahi (MUMS: Mashhad University of Medical Sciences)H-Index: 30
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Abstract Asafoetida, an oleo-gum-resin obtained from the exudates of Ferula assa-foetida L. roots, is traditionally used to treat various diseases including asthma, gastrointestinal disorders, and intestinal parasites. On the basis of Iranian traditional medicine, the main source of asafetida is F. assa-foetida roots. In folk medicine, however, different Ferula species have been used as sources of asafoetida. To identify the original asafoetida that possesses medicinal properties, we should comp...
#1Gabriela de Carvalho Meirelles (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 4
#2Henrique Bridi (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 3
Last.Marina Cardoso Nemitz (UFRJ: Federal University of Rio de Janeiro)
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Abstract Hypericum (Hypericaceae) is a genus that comprises approximately 500 species around the world. The industrial relevance of these plants is based on the occurence of specialized metabolites that exhibit a range of pharmaceutical potential. Besides that, several species are relevant due to their ornamental value. Taking to account the vast market worth of products and processes involving Hypericum, the present study aims to provide a comprehensive overview of patents concerning this subje...
#1Xue-Yan Huang (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Zhao-Xiang Shao (SPU: Shenyang Pharmaceutical University)
Last.Hui-Ming Hua (SPU: Shenyang Pharmaceutical University)H-Index: 17
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Abstract Two new lignanamides, majusamides A and B (1 and 2), and two new alkaloids, chelidoniumine (3) and tetrahydrocoptisine N-oxide (4), together with six known hydroxycinnamic acid amides (HCCA) were isolated from the 75% ethanol extract of Chelidonium majus through the silica gel, Sephadex LH-20, MCI, ODS column chromatography, and semi-HPLC. Their structures were determined on the basis of spectroscopic data and physico-chemical methods. The absolute configurations of 1–3 were determined ...
#1Yupei Yang (Hunan University)H-Index: 1
#2Yongbei Liu (Hunan University)H-Index: 1
Last.Xiaoling ZhouH-Index: 2
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Abstract Four new dibenzocyclooctadiene lignans, named heilaohusus A-D (1–4), one new arylnaphthalene lignan named heilaohusu E (5), and seven known analogues (6–12) were isolated from the roots of Kadsura coccinea. Their structures and configurations were elucidated by a combination of HR-ESI-MS, 1H NMR, 13C NMR, HSQC, HMBC, NOESY and CD spectra. Among the known compounds, compounds 6 and 8–12 were isolated from this plant for the first time. All of compounds were evaluated for their cytotoxici...
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