O45. Amygdala-Prefrontal Coupling as a Marker for Depression Vulnerability, Resilience, and Pathology

Cortico-limbic dysregulation is a leading neurobiological model of major depressive disorder (MDD), but its role in the pathogenesis of MDD is still unclear. We previously reported altered amygdala-prefrontal functional connectivity (FC) in subjects at familial risk for depression, which we discussed as either a marker of vulnerability or resilience. Here, we compared amygdala FC of the at-risk relatives with a newly acquired sample of MDD...