Assessment of the Genetic Architecture of Alzheimer’s Disease Risk in Rate of Memory Decline

Many genetic studies for Alzheimer’s disease (AD) have been focused on the identification of common genetic variants associated with AD risk and not on other aspects of the disease, such as age at onset or rate of dementia progression. There are multiple approaches to untangling the genetic archite cture of these phenotypes. We hypothesized that the genetic architecture of rate of progression is different than the risk for developing AD...