Staphylococcus aureus‐induced complement activation promotes tissue factor‐mediated coagulation

Essentials•Complement, Toll‐like receptors and coagulation cross‐talk in the process of thromboinflammation.•This is explored in a unique human whole‐blood model of S. aureus bacteremia.•Coagulation is here shown as a downstream event of C5a‐induced tissue factor (TF) production.•Combined inhibition of C5 and CD14 efficiently attenuated TF and coagulation.Summary: BackgroundThere is extensive cross‐talk between the complement system, the...