Original paper
TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats
Abstract
Trinucleotide repeat expansions involving CTG/CAG triplets are responsible for several neurodegenerative disorders, including myotonic dystrophy and Huntington's disease. Because expansions trigger the disease, contracting repeat length could be a possible approach to gene therapy for these disorders. Here, we show that a TALEN-induced double-strand break was very efficient at contracting expanded CTG repeats in yeast. We show that RAD51, POL32,...
Paper Details
Title
TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats
Published Date
Feb 1, 2018
Journal
Volume
22
Issue
8
Pages
2146 - 2159
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History