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#1Lydia Maus (GAU: University of Göttingen)
#2Choongku Lee (MPG: Max Planck Society)H-Index: 2
Last. Benjamin H. Cooper (MPG: Max Planck Society)H-Index: 16
view all 10 authors...
Summary Although similar in molecular composition, synapses can exhibit strikingly distinct functional transmitter release and plasticity characteristics. To determine whether ultrastructural differences co-define this functional heterogeneity, we combine hippocampal organotypic slice cultures, high-pressure freezing, freeze substitution, and 3D-electron tomography to compare two functionally distinct synapses: hippocampal Schaffer collateral and mossy fiber synapses. We find that mossy fiber sy...
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#1Lining LiangH-Index: 3
Last. Ping-Yee Law (UMN: University of Minnesota)H-Index: 44
view all 12 authors...
Summary Normally, opioids function in a receptor-dependent manner. They bind to opioid receptors, activate or inhibit receptor activation, and subsequently modulate downstream signal transduction. However, the complex functions of opioids and the low expression of opioid receptors and their endogenous peptide agonists in neural stem cells (NSCs) suggest that some opioids may also modulate NSCs via a receptor-independent pathway. In the current study, two opioids, morphine and naloxone, are demon...
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#1Xie Dang (Fujian Agriculture and Forestry University)H-Index: 3
#2Binqing Chen (Fujian Agriculture and Forestry University)H-Index: 1
Last. Deshu Lin (Fujian Agriculture and Forestry University)H-Index: 8
view all 8 authors...
Summary The flowers of angiosperm species typically contain specialized conical cells. Although substantial progress has been achieved regarding the mechanisms underlying flower development, little is known about how petal cells achieve final conical shape. Here, we use 8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (HPTS) as a fluorescent pH indicator for analyzing the apoplastic pH of conical cells in Arabidopsis and show that normal conical cell expansion requires auxin signaling and a...
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#1Giustina Ferone (NKI-AVL: Netherlands Cancer Institute)H-Index: 2
#2Ji-Ying Song (NKI-AVL: Netherlands Cancer Institute)H-Index: 24
Last. Anton Berns (NKI-AVL: Netherlands Cancer Institute)H-Index: 79
view all 9 authors...
Summary Fibroblast growth factor receptor 1 (FGFR1) is frequently amplified in human small-cell lung cancer (SCLC), but its contribution to SCLC and other lung tumors has remained elusive. Here, we assess the tumorigenic capacity of constitutive-active FGFR1 (FGFR1K656E) with concomitant RB and P53 depletion in mouse lung. Our results reveal a context-dependent effect of FGFR1K656E: it impairs SCLC development from CGRPPOS neuroendocrine (NE) cells, which are considered the major cell of origin ...
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#1Clarice X. F. Lim (Medical University of Vienna)H-Index: 4
#2Bernett Lee (Agency for Science, Technology and Research)H-Index: 21
Last. Heribert Stoiber (Innsbruck Medical University)H-Index: 33
view all 17 authors...
Summary DC-SIGN+ monocyte-derived dendritic cells (mo-DCs) play important roles in bacterial infections and inflammatory diseases, but the factors regulating their differentiation and proinflammatory status remain poorly defined. Here, we identify a microRNA, miR-181a, and a molecular mechanism that simultaneously regulate the acquisition of DC-SIGN expression and the activation state of DC-SIGN+ mo-DCs. Specifically, we show that miR-181a promotes DC-SIGN expression during terminal mo-DC differ...
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#1Daniel Reker (MIT: Massachusetts Institute of Technology)H-Index: 15
#2Yunhua Shi (MIT: Massachusetts Institute of Technology)H-Index: 1
Last. Giovanni TraversoH-Index: 25
view all 9 authors...
Summary Inactive ingredients and generally recognized as safe compounds are regarded by the US Food and Drug Administration (FDA) as benign for human consumption within specified dose ranges, but a growing body of research has revealed that many inactive ingredients might have unknown biological effects at these concentrations and might alter treatment outcomes. To speed up such discoveries, we apply state-of-the-art machine learning to delineate currently unknown biological effects of inactive ...
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#1Abdul G. Lone (WSU: Washington State University)H-Index: 2
#2Troy Bankhead (WSU: Washington State University)H-Index: 6
Summary Arp is an immunogenic protein of the Lyme disease spirochete Borrelia burgdorferi and contributes to joint inflammation during infection. Despite Arp eliciting a strong humoral response, antibodies fail to clear the infection. Given previous evidence of immune avoidance mediated by the antigenically variable lipoprotein of B. burgdorferi, VlsE, we use passive immunization assays to examine whether VlsE protects the pathogen from anti-Arp antibodies. The results show that spirochetes are ...
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#1Tom Adomati (University of Duisburg-Essen)H-Index: 1
#2Lamin B. Cham (University of Duisburg-Essen)H-Index: 1
Last. Eyad Naser (University of Duisburg-Essen)
view all 23 authors...
Summary Infections can result in a temporarily restricted unresponsiveness of the innate immune response, thereby limiting pathogen control. Mechanisms of such unresponsiveness are well studied in lipopolysaccharide tolerance; however, whether mechanisms of tolerance limit innate immunity during virus infection remains unknown. Here, we find that infection with the highly cytopathic vesicular stomatitis virus (VSV) leads to innate anergy for several days. Innate anergy is associated with inducti...
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#1Sophie Uzureau (ULB: Université libre de Bruxelles)H-Index: 6
#2Laurence Lecordier (ULB: Université libre de Bruxelles)H-Index: 19
Last. Rita La Rovere (Katholieke Universiteit Leuven)H-Index: 10
view all 24 authors...
Summary The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk of kidney disease. APOL1 and APOL3 are death-promoting proteins that are partially associated with the endoplasmic reticulum and Golgi membranes. We report that in podocytes, either APOL1 C-terminal helix truncation (APOL1Δ) or APOL3 deletion (APOL3KO) induces similar actomyosin reorganization linked to the inhib...
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#1Christopher K. Lafferty (McGill University)H-Index: 1
#2Angela K. Yang (McGill University)H-Index: 1
Last. Jonathan P. Britt (McGill University)H-Index: 12
view all 4 authors...
Summary The nucleus accumbens (NAc) contributes to behavioral inhibition and compulsions, but circuit mechanisms are unclear. Recent evidence suggests that amygdala and thalamic inputs exert opposing control over behavior, much like direct and indirect pathway output neurons. Accordingly, opponent processes between these NAc inputs or cell types may underlie efficient reward seeking. We assess the contributions of these circuit elements to mouse operant behavior during recurring conditions when ...
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