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Cell Reports
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Papers 7634
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#1Haruna Nakajo (UTokyo: University of Tokyo)
#2Ming-Yi Chou (NTU: National Taiwan University)H-Index: 11
Last. Hitoshi Okamoto (UTokyo: University of Tokyo)H-Index: 52
view all 7 authors...
Summary Many animals fight for dominance between conspecifics. Because winners could obtain more resources than losers, fighting outcomes are important for the animal's survival, especially in a situation with insufficient resources, such as hunger. However, it remains unclear whether and how hunger affects fighting outcomes. Herein, we investigate the effects of food deprivation on brain activity and fighting behaviors in zebrafish. We report that starvation induces winning in social conflicts....
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#1Mouna Triki (Katholieke Universiteit Leuven)
#2Gianmarco Rinaldi (Katholieke Universiteit Leuven)H-Index: 8
Last. Martin F. Orth (LMU: Ludwig Maximilian University of Munich)H-Index: 9
view all 13 authors...
Summary Cancer cells display an increased plasticity in their lipid metabolism, which includes the conversion of palmitate to sapienate via the enzyme fatty acid desaturase 2 (FADS2). We find that FADS2 expression correlates with mammalian target of rapamycin (mTOR) signaling and sterol regulatory element-binding protein 1 (SREBP-1) activity across multiple cancer types and is prognostic in some cancer types. Accordingly, activating mTOR signaling by deleting tuberous sclerosis complex 2 (Tsc2) ...
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#1Tamihiro Kamata (Leicester Royal Infirmary)H-Index: 8
#2Tsz Y. So (Leicester Royal Infirmary)
Last. Catrin Pritchard (Leicester Royal Infirmary)H-Index: 29
view all 8 authors...
The tumor microenvironment (TME) consists of different cell types, including tumor-associated macrophages (TAMs) and tumor-associated fibroblasts (TAFs). How these cells interact and contribute to lung carcinogenesis remains elusive. Using G12DKRAS- and V600EBRAF-driven mouse lung models, we identify the pleiotropic glycoprotein stanniocalcin-1 (STC1) as a regulator of TAM-TAF interactions. STC1 is secreted by TAFs and suppresses TAM differentiation, at least in part, by sequestering the binding...
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#1Shuo Huang (Alberta Children's Hospital)H-Index: 3
#2Zizhen Zhang (Alberta Children's Hospital)H-Index: 4
Last. Gerald W. Zamponi (Alberta Children's Hospital)H-Index: 71
view all 10 authors...
Summary The medial prefrontal cortex (mPFC) is a brain region involved in the affective components of pain and undergoes plasticity during the development of chronic pain. Dopamine (DA) is a key neuromodulator in the mesocortical circuit and modulates working memory and aversion. Although DA inputs into the mPFC are known to modulate plasticity, whether and how these inputs affect pain remains incompletely understood. By using optogenetics, we find that phasic activation of DA inputs from the ve...
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#1Stephanie Sibinelli-Sousa (USP: University of São Paulo)
#2Julia T. Hespanhol (USP: University of São Paulo)
Last. Ethel Bayer-Santos (USP: University of São Paulo)H-Index: 10
view all 9 authors...
Summary Type VI secretion systems (T6SSs) are nanomachines used by bacteria to inject toxic effectors into competitors. The identity and mechanism of many effectors remain unknown. We characterized a Salmonella T6SS antibacterial effector called Tlde1 that is toxic in target-cell periplasm and is neutralized by its cognate immunity protein (Tldi1). Microscopy analysis reveals that cells expressing Tlde1 stop dividing and lose cell envelope integrity. Bioinformatic analysis uncovers similarities ...
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#1Mark A. Chapman (KI: Karolinska Institutet)
#2Muhammad Arif (KTH: Royal Institute of Technology)H-Index: 6
Last. Carl Johan Sundberg (KI: Karolinska Institutet)H-Index: 32
view all 7 authors...
Summary To better understand the health benefits of lifelong exercise in humans, we conduct global skeletal muscle transcriptomic analyses of long-term endurance- (9 men, 9 women) and strength-trained (7 men) humans compared with age-matched untrained controls (7 men, 8 women). Transcriptomic analysis, Gene Ontology, and genome-scale metabolic modeling demonstrate changes in pathways related to the prevention of metabolic diseases, particularly with endurance training. Our data also show promine...
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#1Birthe Meineke (KI: Karolinska Institutet)H-Index: 1
#2Johannes Heimgärtner (KI: Karolinska Institutet)H-Index: 1
Last. Simon J. Elsässer (KI: Karolinska Institutet)H-Index: 14
view all 5 authors...
Summary The pyrrolysyl-tRNA/pyrrolysyl-tRNA synthetase (PylT/RS) pair from the archaeon Methanosarcina mazei (Mma) is widely used in protein engineering to site-specifically introduce noncanonical amino acids (ncAAs) through nonsense codon suppression. Here, we engineer the PylT/RS pair encoded by Methanogenic archaeon ISO4-G1 (G1) to be orthogonal to Mma PylT/RS and alter the G1 PylRS active site to accept a complementary ncAA spectrum. We combine the resulting mutual orthogonal pairs for site-...
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#1Renato Socodato (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 8
#2Camila C. Portugal (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 13
Last. Filipa I. BaptistaH-Index: 12
view all 20 authors...
Summary Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in adult microglia is sufficient to trigger spontaneous microglia activation, producing a neurological phenotype (including synapse and neuron loss, impairment of long-term potentiation [LTP], formation of β-amyloid plaques, and memory deficits). Mechanistically, loss of Rhoa in microglia triggers Src activation ...
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#1Mei YangH-Index: 1
#1Mei Yang (University of Texas Health Science Center at San Antonio)H-Index: 1
Last. Kexin XuH-Index: 15
view all 19 authors...
Although accumulating evidence has demonstrated that individual enhancer RNAs (eRNAs) exert critical biological functions rather than being passive transcriptional byproducts, the mechanisms of action of these non-coding transcripts remain obscure and divergent. By analyzing genome-wide nascent transcript profiling in breast cancer cells, we identified a special group of eRNAs that are functionally important for estrogen-induced transcriptional repression. Using eRNAs of TM4SF1 and EFEMP1 as the...
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Summary Durable humoral immunity against epidemic infectious disease requires the survival of long-lived plasma cells (LLPCs). LLPC longevity is dependent on metabolic programs distinct from short-lived plasma cells (SLPCs); however, the mechanistic basis for this difference is unclear. We have previously shown that CD28, the prototypic T cell costimulatory receptor, is expressed on both LLPCs and SLPCs but is essential only for LLPC survival. Here we show that CD28 transduces pro-survival signa...
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