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#1Cristina Batlle (Autonomous University of Barcelona)H-Index: 4
#2Peiguo Yang (St. Jude Children's Research Hospital)H-Index: 12
Last.Salvador Ventura (Autonomous University of Barcelona)H-Index: 41
view all 10 authors...
Summary Prion-like proteins form multivalent assemblies and phase separate into membraneless organelles. Heterogeneous ribonucleoprotein D-like (hnRNPDL) is a RNA-processing prion-like protein with three alternative splicing (AS) isoforms, which lack none, one, or both of its two disordered domains. It has been suggested that AS might regulate the assembly properties of RNA-processing proteins by controlling the incorporation of multivalent disordered regions in the isoforms. This, in turn, woul...
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#1Qiang LiH-Index: 2
#2Fengbiao MaoH-Index: 7
Last.Rajesh C. RaoH-Index: 12
view all 11 authors...
Summary How ubiquitous transcription factors (TFs) coordinate temporal inputs from broadly expressed epigenetic factors to control cell fate remains poorly understood. Here, we uncover a molecular relationship between p53, an abundant embryonic TF, and WDR5, an essential member of the MLL chromatin modifying complex, that regulates mouse embryonic stem cell fate. Wild-type Wdr5 or transient Wdr5 knockout promotes a distinct pattern of global chromatin accessibility and spurs neuroectodermal diff...
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#1Olivia R. Buonarati (Anschutz Medical Campus)
#2Sarah G. Cook (Anschutz Medical Campus)H-Index: 1
Last.K. Ulrich Bayer (Anschutz Medical Campus)H-Index: 25
view all 11 authors...
Summary DAPK1 binding to GluN2B was prominently reported to mediate ischemic cell death in vivo. DAPK1 and CaMKII bind to the same GluN2B region, and their binding is mutually exclusive. Here, we show that mutating the binding region on GluN2B (L1298A/R1300Q) protected against neuronal cell death induced by cardiac arrest followed by resuscitation. Importantly, the GluN2B mutation selectively abolished only CaMKII, but not DAPK1, binding. During ischemic or excitotoxic insults, CaMKII further ac...
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#1Constance Alabert (University of Copenhagen Faculty of Health Sciences)
#2Carolin Loos (TUM: Technische Universität München)H-Index: 5
Last.Axel Imhof (LMU: Ludwig Maximilian University of Munich)H-Index: 55
view all 11 authors...
Summary Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of new unmodified histones during each cell cycle, and the principles governing heritability remain unclear. We take a quantitative computational modeling approach to describe propagation of histone H3K27 and H3K36 methylation states. We me...
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#1Madlaina Boillat (University of Geneva)H-Index: 1
#2Pierre-Mehdi Hammoudi (University of Geneva)H-Index: 4
Last.Dominique Soldati-Favre (University of Geneva)H-Index: 36
view all 7 authors...
Summary In rodents, the decrease of felid aversion induced by Toxoplasma gondii, a phenomenon termed fatal attraction, is interpreted as an adaptive manipulation by the neurotropic protozoan parasite. With the aim of understanding how the parasite induces such specific behavioral modifications, we performed a multiparametric analysis of T. gondii-induced changes on host behavior, physiology, and brain transcriptome as well as parasite cyst load and distribution. Using a set of complementary beha...
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#1Jenny Joutsen (Åbo Akademi University)H-Index: 4
#2Alejandro J. Da Silva (Åbo Akademi University)
Last.Lea Sistonen (Åbo Akademi University)H-Index: 52
view all 11 authors...
Summary Maintenance of protein homeostasis, through inducible expression of molecular chaperones, is essential for cell survival under protein-damaging conditions. The expression and DNA-binding activity of heat shock factor 2 (HSF2), a member of the heat shock transcription factor family, increase upon exposure to prolonged proteotoxicity. Nevertheless, the specific roles of HSF2 and the global HSF2-dependent gene expression profile during sustained stress have remained unknown. Here, we found ...
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#1Gabriella Saro (University of Fribourg)H-Index: 1
#2Andrei-Stefan Lia (University of Fribourg)
Last.Dominique A. Glauser (University of Fribourg)H-Index: 16
view all 6 authors...
Summary Pain sensation and aversive behaviors entail the activation of nociceptor neurons, whose function is largely conserved across animals. The functional heterogeneity of nociceptors and ethical concerns are challenges for their study in mammalian models. Here, we investigate the function of a single type of genetically identified C. elegans thermonociceptor named FLP. Using calcium imaging in vivo, we demonstrate that FLP encodes thermal information in a tonic and graded manner over a wide ...
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#1Davide Pisu (Cornell University)H-Index: 2
#2Davide Pisu (Cornell University)H-Index: 1
Last.David G. Russell (Cornell University)H-Index: 73
view all 4 authors...
Summary Dissecting the in vivo host-pathogen interplay is crucial to understanding the molecular mechanisms governing control or progression of intracellular infections. In this work, we explore the in vivo molecular dynamics of Mtb infection by performing dual RNA-seq on Mycobacterium tuberculosis-infected, ontogenetically distinct macrophage lineages isolated directly from murine lungs. We first define an in vivo signature of 180 genes specifically upregulated by Mtb in mouse lung macrophages,...
1 CitationsSource
#1Zhuo Yang (THU: Tsinghua University)
#2Mengmeng Li (THU: Tsinghua University)
Last.Qianwen Sun (THU: Tsinghua University)
view all 3 authors...
Summary Preventing transcription-replication head-on conflict (HO-TRC)-triggered R-loop formation is essential for maintaining genome integrity in bacteria, plants, and mammals. The R-loop eraser RNase H can efficiently relax HO-TRCs. However, it is not clear how organisms resist HO-TRC-triggered R-loops when RNase H proteins are deficient. By screening factors that may relieve R-loop accumulation in the Arabidopsis atrnh1c mutant, we find that overexpression of the R-loop helicase RHON1 can res...
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