Lucie Poggi
University of Paris
Publications 4
#1Lucie Poggi (University of Paris)H-Index: 2
#2Bruno DumasH-Index: 1
Last.Guy-Franck Richard (CNRS: Centre national de la recherche scientifique)H-Index: 23
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1 CitationsSource
#1Valentine Mosbach (Pasteur Institute)H-Index: 2
#2Lucie PoggiH-Index: 2
Last.Guy-Franck Richard (Pasteur Institute)H-Index: 23
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Trinucleotide repeats are a particular class of microsatellites whose large expansions are responsible for at least two dozen human neurological and developmental disorders. Slippage of the two complementary DNA strands during replication, homologous recombination or DNA repair is generally accepted as a mechanism leading to repeat length changes, creating expansions and contractions of the repeat tract. The present review focuses on recent developments on double-strand break repair involving tr...
7 CitationsSource
#1Valentine Mosbach (Pasteur Institute)H-Index: 3
#2Lucie Poggi (Pasteur Institute)H-Index: 2
Last.Guy-Franck Richard (Pasteur Institute)H-Index: 23
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Trinucleotide repeat expansions involving CTG/CAG triplets are responsible for several neurodegenerative disorders, including myotonic dystrophy and Huntington’s disease. Because expansions trigger the disease, contracting repeat length could be a possible approach to gene therapy for these disorders. Here, we show that a TALEN-induced double-strand break was very efficient at contracting expanded CTG repeats in yeast. We show that RAD51, POL32, and DNL4 are dispensable for double-strand break r...
9 CitationsSource
#1David Viterbo (Pasteur Institute)H-Index: 2
#2Astrid Marchal (Pasteur Institute)H-Index: 1
Last.Guy-Franck Richard (Pasteur Institute)H-Index: 23
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2 CitationsSource