Original paper
Predicting inhibitory and activatory drug targets by chemically and genetically perturbed transcriptome signatures
Abstract
Genome-wide identification of all target proteins of drug candidate compounds is a challenging issue in drug discovery. Moreover, emerging phenotypic effects, including therapeutic and adverse effects, are heavily dependent on the inhibition or activation of target proteins. Here we propose a novel computational method for predicting inhibitory and activatory targets of drug candidate compounds. Specifically, we integrated chemically-induced and...
Paper Details
Title
Predicting inhibitory and activatory drug targets by chemically and genetically perturbed transcriptome signatures
Published Date
Jan 9, 2018
Journal
Volume
8
Issue
1
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Notes
History