Allograft Failure After Alemtuzumab Induction in Renal Transplantation.

Introduction. Alemtuzumab [AZ] is a potent lymphodepleting anti CD-52 monoclonal antibody, which is used as an induction agent in renal transplantation. Early observations suggested that this agent might induce “Prope Tolerance” and reduce graft loss from rejection. The aim of this study was to describe the medium to long-term outcomes of a large cohort of renal transplant recipients following AZ induction. Methods. We retrospectively studied...