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#1Anoop N. KoshyH-Index: 3
#2H.M. Omar FarouqueH-Index: 12
Last. Paul J GowH-Index: 25
view all 10 authors...
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#1Giuseppe CullaroH-Index: 4
#2Elizabeth C. VernaH-Index: 29
Last. Jennifer C. LaiH-Index: 24
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#1Maria VargasH-Index: 10
Last. Giuseppe ServilloH-Index: 15
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#1Ashrit MultaniH-Index: 1
#2Yasbanoo MoayediH-Index: 5
Last. Heather J. RossH-Index: 47
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#1Satoshi Miyairi (Cleveland Clinic)H-Index: 2
#2William M. Baldwin (Cleveland Clinic)H-Index: 42
Last. Robert L. Fairchild (Cleveland Clinic)H-Index: 44
view all 4 authors...
Antibody-mediated rejection (AMR) is an important cause of graft loss and continues to present a formidable obstacle to successful transplantation. Unresolved problems continue to be the absence of effective strategies to ablate the donor-specific antibody (DSA) response as well as to attenuate the antibody-mediated graft tissue injury. While properties of DSA that cause greater graft tissue injury and the characteristic microvascular pathology of the graft injury are well documented, the mechan...
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#1Jiro Kusakabe (Kyoto University)H-Index: 1
#2Koichiro Hata (Kyoto University)H-Index: 18
Last. Hirokazu Tanaka (Kyoto University)H-Index: 13
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BACKGROUND: Hepatic ischemia/reperfusion injury (IRI) is a serious complication in liver surgeries, including transplantation. Complement activation seems to be closely involved in hepatic IRI; however, no complement-targeted intervention has been clinically applied. We investigated the therapeutic potential of Complement-5 (C5)-targeted regulation in hepatic IRI. METHODS: C5-knockout (KO, B10D2/oSn) and their corresponding wild-type mice (WT, B10D2/nSn) were exposed to 90-minute partial (70%) h...
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#1Jing Xu (UMMS: University of Massachusetts Medical School)H-Index: 1
#2Julianna E. Buchwald (UMMS: University of Massachusetts Medical School)H-Index: 1
Last. Paulo N.A. Martins (UMMS: University of Massachusetts Medical School)H-Index: 19
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Because of the high demand of organs, the usage of marginal grafts has increased. These marginal organs have a higher risk of developing ischemia-reperfusion injuries, which can lead to post-transplant complications. Ex-situ machine perfusion, compared to the traditional static cold storage, may better protect these organs from ischemia-reperfusion injuries. In addition, machine perfusion can also act as a platform for dynamic administration of pharmacological agents or gene therapy to further i...
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#1Benno Cardini (Innsbruck Medical University)H-Index: 5
#2Rupert Oberhuber (Innsbruck Medical University)H-Index: 11
Last. Harald Mair (Innsbruck Medical University)
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BACKGROUND: Normothermic machine perfusion (NMP) bears the potential for significant prolongation of liver preservation prior to transplantation. Although safety and feasibility have been recently published, not data are available describing the significant challenges of establishing NMP programs outside clinical studies. We herein present our experience and propose a multidisciplinary approach for liver NMP in the clinical routine. METHODS AND RESULTS: In February 2018, liver NMP was introduced...
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