Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer
Abstract
Cancer cells have more mutations in their mitochondrial DNA (mtDNA) than do normal cells, and pathogenic mutations in the genes encoding mitochondrial NADH dehydrogenase (ND) subunits have been found to enhance the invasive and metastatic ability of various tumour cells in animal experiments. However, it is unknown whether single-nucleotide variants (SNVs) of the ND genes that decrease complex I activity are involved in distant metastasis in...
Paper Details
Title
Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer
Published Date
Nov 14, 2017
Journal
Volume
7
Issue
1
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