Miho Akimoto
Teikyo University
Publications 21
#1Miho Akimoto (Teikyo University)H-Index: 9
#2Riruke Maruyama (Shimane University)H-Index: 10
Last.Keizo Takenaga (Shimane University)H-Index: 31
view all 5 authors...
The association between lower circulating adiponectin (APN) levels and the development of pancreatic cancer has been reported. However, the effect of APN on the growth and survival of pancreatic cancer cells remains elusive. Here, we investigate the effects of the anti-diabetic APN receptor (AdipoR) agonist AdipoRon and APN on human pancreatic cancer cells. We found that AdipoRon, but not APN, induces MIAPaCa-2 cell death, mainly through necroptosis. Mechanistically, although both AdipoRon and A...
8 CitationsSource
#1Miho Akimoto (Shimane University)H-Index: 9
#2Keizo Takenaga (Shimane University)H-Index: 31
Abstract Interleukin-33 (IL-33) has been identified as a natural ligand of ST2L. IL-33 primarily acts as a key regulator of Th2 responses through binding to ST2L, which is antagonized by soluble ST2 (sST2). The IL-33/ST2L axis is involved in various inflammatory pathologies, including ulcerative colitis (UC). Several recent investigations have also suggested that the IL-33/ST2L axis plays a role in colorectal cancer (CRC) progression. In CRC, tumor- and stroma-derived IL-33 may activate ST2L on ...
6 CitationsSource
#1Nobuko KoshikawaH-Index: 14
#2Miho Akimoto (Teikyo University)H-Index: 9
Last.Keizo Takenaga (Shimane University)H-Index: 31
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Cancer cells have more mutations in their mitochondrial DNA (mtDNA) than do normal cells, and pathogenic mutations in the genes encoding mitochondrial NADH dehydrogenase (ND) subunits have been found to enhance the invasive and metastatic ability of various tumour cells in animal experiments. However, it is unknown whether single-nucleotide variants (SNVs) of the ND genes that decrease complex I activity are involved in distant metastasis in human clinical samples. Here, we demonstrated the enha...
5 CitationsSource
#1Nanae HarashimaH-Index: 19
#2Keizo TakenagaH-Index: 31
Last.Mamoru HaradaH-Index: 22
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// Nanae Harashima 1 , Keizo Takenaga 2 , Miho Akimoto 2 and Mamoru Harada 1 1 Department of Immunology, Shimane University Faculty of Medicine, Shimane, Japan 2 Department of Life Science, Shimane University Faculty of Medicine, Shimane, Japan Correspondence to: Mamoru Harada, email: Keywords: hypoxia, HIF-2α, TRAIL, surviving, pancreatic cancer Received: September 07, 2016 Accepted: March 20, 2017 Published: April 17, 2017 ABSTRACT Cancer cells develop resistance t...
4 CitationsSource
#1Miho Akimoto (Shimane University)H-Index: 9
#2Riruke Maruyama (Shimane University)H-Index: 4
Last.Keizo Takenaga (Shimane University)H-Index: 31
view all 5 authors...
Interleukin-33 (IL-33) was recently shown to be involved in the inflammatory tumour microenvironment and the progression of colorectal cancer (CRC). We report here that the expression level of sST2, a soluble form of the IL-33 receptor (ST2L), is inversely associated with the malignant growth of CRC. sST2 is downregulated in high-metastatic cells compared with low-metastatic human and mouse CRC cells. Knockdown of sST2 in low-metastatic cells enhances tumour growth, metastasis and tumour angioge...
21 CitationsSource
#1Miho Akimoto (Shimane University)H-Index: 9
#2Jun-Ichi Hayashi (University of Tsukuba)H-Index: 39
Last.Keizo Takenaga (Shimane University)H-Index: 31
view all 5 authors...
The proinflammatory interleukin-33 (IL-33) binds to its receptor ST2L on the surface of immune cells and stimulates the production of Th2 cytokines; however, the effects of IL-33 on tumour cells are poorly understood. Here we show that ST2 was significantly downregulated in human lung cancer tissues and cells compared with normal lung tissues and cells. IL-33 expression was also inversely correlated with the stages of human lung cancers. In accordance with this finding, low-metastatic cells but ...
17 CitationsSource
#1Miho Akimoto (Shimane University)H-Index: 9
#2Mari Iizuka (Shimane University)H-Index: 5
Last.Keizo Takenaga (Shimane University)H-Index: 31
view all 5 authors...
The extract of ginger (Zingiber officinale Roscoe) and its major pungent components, [6]-shogaol and [6]-gingerol, have been shown to have an anti-proliferative effect on several tumor cell lines. However, the anticancer activity of the ginger extract in pancreatic cancer is poorly understood. Here, we demonstrate that the ethanol-extracted materials of ginger suppressed cell cycle progression and consequently induced the death of human pancreatic cancer cell lines, including Panc-1 cells. The u...
51 CitationsSource
#1Miho Hattori (Shimane University)H-Index: 3
#2Koshi Kawakami (Shimane University)H-Index: 5
Last.Yoshio Honma (Shimane University)H-Index: 33
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Aims and background. MK615 is produced from Japanese apricot and contains several cyclic triterpenes, such as oleanolic and ursolic acids. MK615 was shown to strongly suppress cutaneous in-transit metastasis in a patient with malignant melanoma. The present investigation was undertaken to clarify the antitumor effects of MK615 in vitro and in vivo. Methods. Several human cancer cell lines were exposed to MK615 for 7 days to examine its antiproliferative effects. The effect of MK615 on in vivo gr...
8 CitationsSource
#1Yoshihide Shimojo (Shimane University)H-Index: 3
#2Miho Akimoto (Shimane University)H-Index: 9
Last.Keizo Takenaga (Shimane University)H-Index: 31
view all 7 authors...
Hypoxia has been shown to promote metastasis of cancer cells through induction of epithelial-mesenchymal transition (EMT). It is also known to cause generation of reactive oxygen species (ROS). We investigated here the role of ROS in hypoxia-induced EMT and whether attenuation of ROS by antioxidants suppresses hypoxia-induced EMT and metastasis of human pancreatic cancer cells in a xenograft nude mouse model. PANC-1 and MiaPaCa-2 cells exposed to hypoxia (1 % O2) showed increased ROS generation ...
48 CitationsSource
#1Miho AkimotoH-Index: 9
#2Hideko NagasawaH-Index: 27
Last.Keizo TakenagaH-Index: 31
view all 6 authors...
An inhibitor of HIF-α subunit expression suppresses hypoxia-induced dedifferentiation of human NSCLC into cancer stem cell-like cells
2 CitationsSource