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Distinct Associations Between Low Positive Affect, Panic, and Neural Responses to Reward and Threat During Late Stages of Affective Picture Processing

Published on Jan 1, 2018in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
· DOI :10.1016/j.bpsc.2017.09.013
Anna Weinberg26
Estimated H-index: 26
(McGill University),
Aislinn Sandre1
Estimated H-index: 1
(McGill University)
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Abstract
Abstract Background Abnormal patterns of attention to threat and reward have been proposed as potential mechanisms of dysfunction in anxiety and mood disorders. However, research on this topic has been inconsistent, perhaps because of both clinical heterogeneity in the samples assessed and measurement of attentional biases that is temporally imprecise. Methods The present study measured transdiagnostic symptoms of anxiety and depression in 205 young adults and recorded affect-modulated event-related potentials in response to task-irrelevant pictures in a speeded response task. Results Low positive affect was uniquely associated with reduced modulation of later event-related potentials (i.e., the P300 and the late positive potential) by rewarding images, suggesting deficits in sustained attention to reward. Low positive affect was also associated with a blunted threat-elicited late positive potential. Symptoms of panic were associated with an increased N1 to rewarding images, as well as an increased late positive potential to all picture types. Conclusions These data suggest that dysfunction in neural markers of sustained attention to threat and reward relate in specific ways to transdiagnostic symptom dimensions of anxiety and depression. Moreover, event-related potentials are likely to be useful in investigations of the time course of attentional abnormalities associated with these symptom dimensions.
  • References (112)
  • Citations (4)
Cite
References112
Newest
Published on Jul 1, 2017in Journal of Affective Disorders4.08
Ellen M. Kessel9
Estimated H-index: 9
(SBU: Stony Brook University),
Autumn Kujawa19
Estimated H-index: 19
(PSU: Pennsylvania State University)
+ 4 AuthorsDaniel N. Klein72
Estimated H-index: 72
(SBU: Stony Brook University)
Abstract Background The Research Domain Criteria (RDoC) constructs of Positive Valence Systems (PVS) and Negative Valence Systems (NVS) are presumed to manifest behaviorally through early-emerging temperamental negative affectivity (NA) and positive affectivity (PA). The late positive potential (LPP) is a physiological measure of attention towards both negative and positive emotional stimuli; however, its associations with behavioral aspects of PVS and NVS have yet to be examined. Methods In a c...
Published on Jan 1, 2017in Journal of Abnormal Psychology5.52
Roman Kotov36
Estimated H-index: 36
(SBU: Stony Brook University),
Robert F. Krueger91
Estimated H-index: 91
(UMN: University of Minnesota)
+ 37 AuthorsLee Anna Clark68
Estimated H-index: 68
(ND: University of Notre Dame)
The reliability and validity of traditional taxonomies are limited by arbitrary boundaries between psychopathology and normality, often unclear boundaries between disorders, frequent disorder co-occurrence, heterogeneity within disorders, and diagnostic instability. These taxonomies went beyond evidence available on the structure of psychopathology and were shaped by a variety of other considerations, which may explain the aforementioned shortcomings. The Hierarchical Taxonomy Of Psychopathology...
Published on Jun 1, 2016in Cognitive Therapy and Research2.28
Annmarie MacNamara16
Estimated H-index: 16
(UIC: University of Illinois at Chicago),
Roman Kotov36
Estimated H-index: 36
(SBU: Stony Brook University),
Greg Hajcak64
Estimated H-index: 64
(SBU: Stony Brook University)
The delineation of specific versus overlapping mechanisms in generalized anxiety disorder (GAD) and major depressive disorder (MDD) could shed light on the integrity of these diagnostic categories. For example, negative emotion generation is one mechanism that may be especially relevant to both disorders. Emotional processing abnormalities were examined among 97 outpatients with GAD or MDD and 25 healthy adults, using the late positive potential (LPP), an event-related potential that is larger f...
Published on Mar 1, 2016in Psychophysiology3.38
Michael J. Kozak28
Estimated H-index: 28
,
Bruce N. Cuthbert54
Estimated H-index: 54
This article describes the National Institute of Mental Health's Research Domain Criteria (RDoC) initiative. The description includes background, rationale, goals, and the way the initiative has been developed and organized. The central RDoC concepts are summarized and the current matrix of constructs that have been vetted by workshops of extramural scientists is depicted. A number of theoretical and methodological issues that can arise in connection with the nature of RDoC constructs are highli...
Published on Mar 1, 2016in Psychophysiology3.38
Peter Lang115
Estimated H-index: 115
,
Lisa M. McTeague17
Estimated H-index: 17
(Sewanee: The University of the South),
Margaret M. Bradley66
Estimated H-index: 66
Evidence is presented supporting a dimension of defensive reactivity that varies across the anxiety disorder spectrum and is defined by physiological responses during threat-imagery challenges that covary with objective measures of psychopathology. Previous imagery studies of anxiety disorders are reviewed, highlighting that, regardless of contemporary diagnostic convention, reliable psychophysiological patterns emerge for patients diagnosed with circumscribed fear compared to those diagnosed wi...
Published on Jan 1, 2016in Journal of Abnormal Psychology5.52
Anna Weinberg26
Estimated H-index: 26
,
Greg Perlman12
Estimated H-index: 12
+ 1 AuthorsGreg Hajcak64
Estimated H-index: 64
Abnormal patterns of attention to threat and reward have been proposed as potential mechanisms of dysfunction in anxiety and unipolar depressive disorders. However, few studies have simultaneously examined whether these patterns of attention are shared among disorders or distinguish between them. In the present study, we recorded the Late Positive Potential (LPP), an event-related potential and putative index of motivated attention, from 145 patients with anxiety and unipolar depressive disorder...
Published on Nov 1, 2015
Roman Kotov36
Estimated H-index: 36
Published on Nov 1, 2015in International Journal of Psychophysiology2.41
Stewart A. Shankman24
Estimated H-index: 24
(UIC: University of Illinois at Chicago),
Stephanie M. Gorka16
Estimated H-index: 16
(UIC: University of Illinois at Chicago)
Abstract The NIMH Research Domain Criteria (RDoC) initiative seeks to re-conceptualize psychopathology by identifying transdiagnostic constructs that reflect core mechanisms of psychopathology. Although the RDoC framework has been discussed in many prior papers, there are several methodological and conceptual points that have yet to be fully specified. For example, little discussion exists on the importance of distinguishing each construct's nomological network and linking it to risk for psychop...
Published on Sep 1, 2015in Psychological Medicine5.64
Brady D. Nelson17
Estimated H-index: 17
,
Greg Perlman12
Estimated H-index: 12
+ 2 AuthorsRoman Kotov36
Estimated H-index: 36
BACKGROUND: The late positive potential (LPP) is an event-related potential component that is sensitive to the motivational salience of stimuli. Children with a parental history of depression, an indicator of risk, have been found to exhibit an attenuated LPP to emotional stimuli. Research on depressive and anxiety disorders has organized these conditions into two empirical classes: distress and fear disorders. The present study examined whether parental history of distress and fear disorders wa...
Cited By4
Newest
Published on Sep 12, 2019in Journal of Abnormal Child Psychology3.41
Diana J. Whalen14
Estimated H-index: 14
(WashU: Washington University in St. Louis),
Kirsten Gilbert7
Estimated H-index: 7
(WashU: Washington University in St. Louis)
+ 4 AuthorsDeanna M75
Estimated H-index: 75
(WashU: Washington University in St. Louis)
Reductions in positive affect are a salient feature of preschool-onset major depressive disorder. Yet, little is known about the psychophysiological correlates of this blunted positive affect and whether reduced physiological responding to pleasant stimuli may differentiate depressed and healthy young children. 120 four-to-seven year old children with current depression and 63 psychiatrically healthy 4-to-7 year old children completed a simple picture-viewing task of pleasant and neutral picture...
Published on Jul 1, 2019in Biological Psychology2.63
Aislinn Sandre1
Estimated H-index: 1
(McGill University),
Rosemary C. Bagot3
Estimated H-index: 3
(McGill University),
Anna Weinberg26
Estimated H-index: 26
(McGill University)
Abstract Individual differences in neural response to appetitive and aversive stimuli may confer vulnerability to stress-related psychopathology, including depression and anxiety. However, the specificity of this association with symptoms of depression and anxiety within the context of real-world stress is not well understood. The present study examined whether neural responses to appetitive and aversive images, measured by the late positive potential (LPP), prospectively predict symptoms of dep...
Annmarie MacNamara16
Estimated H-index: 16
(A&M: Texas A&M University),
T. Bryan Jackson1
Estimated H-index: 1
(A&M: Texas A&M University)
+ 2 AuthorsK. Luan Phan52
Estimated H-index: 52
(UIC: University of Illinois at Chicago)
Abstract Background Internalizing disorders such as anxiety may be characterized by an imbalance between bottom-up (stimulus-driven) and top-down (goal-directed) attention. The late positive potential (LPP) can be used to assess these processes when task-irrelevant negative and neutral pictures are presented within a working memory paradigm. Prior work using this paradigm has found that working memory load reduces the picture-elicited LPP across participants; however, anxious individuals showed ...
Published on Oct 1, 2018in International Journal of Psychophysiology2.41
Paige Ethridge2
Estimated H-index: 2
(McGill University),
Anna Weinberg26
Estimated H-index: 26
(McGill University)
Abstract Reward-related event-related potentials (ERPs) are often used to index individual differences that signal the presence or predict the onset of psychopathology. However, relatively little research has explored the psychometric properties of reward-related ERPs. Without understanding their psychometric properties, the value of using ERPs as biomarkers for psychopathology is limited. The present study, therefore, sought to establish the internal consistency reliability and convergent valid...
Aislinn Sandre1
Estimated H-index: 1
(McGill University),
Paige Ethridge2
Estimated H-index: 2
(McGill University)
+ 1 AuthorsAnna Weinberg26
Estimated H-index: 26
(McGill University)
Childhood maltreatment increases lifetime vulnerability for psychopathology. One proposed mechanism for this association is that early maltreatment increases vigilance for and attention to subtle threat cues, persisting outside of the environment in which maltreatment occurs. To test this possibility, the present study examined neural responses to ambiguous and nonambiguous threatening facial expressions in a sample of 25 adults reporting a history of low-to-moderate levels of abuse in childhood...
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