Match!

Distinct Associations Between Low Positive Affect, Panic, and Neural Responses to Reward and Threat During Late Stages of Affective Picture Processing

Published on Jan 1, 2018in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
· DOI :10.1016/j.bpsc.2017.09.013
Anna Weinberg27
Estimated H-index: 27
(McGill University),
Aislinn Sandre2
Estimated H-index: 2
(McGill University)
Abstract
Abstract Background Abnormal patterns of attention to threat and reward have been proposed as potential mechanisms of dysfunction in anxiety and mood disorders. However, research on this topic has been inconsistent, perhaps because of both clinical heterogeneity in the samples assessed and measurement of attentional biases that is temporally imprecise. Methods The present study measured transdiagnostic symptoms of anxiety and depression in 205 young adults and recorded affect-modulated event-related potentials in response to task-irrelevant pictures in a speeded response task. Results Low positive affect was uniquely associated with reduced modulation of later event-related potentials (i.e., the P300 and the late positive potential) by rewarding images, suggesting deficits in sustained attention to reward. Low positive affect was also associated with a blunted threat-elicited late positive potential. Symptoms of panic were associated with an increased N1 to rewarding images, as well as an increased late positive potential to all picture types. Conclusions These data suggest that dysfunction in neural markers of sustained attention to threat and reward relate in specific ways to transdiagnostic symptom dimensions of anxiety and depression. Moreover, event-related potentials are likely to be useful in investigations of the time course of attentional abnormalities associated with these symptom dimensions.
  • References (113)
  • Citations (7)
📖 Papers frequently viewed together
2 Citations
1,194 Citations
530 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References113
Newest
#1Ellen M. Kessel (SBU: Stony Brook University)H-Index: 10
#2Autumn Kujawa (PSU: Pennsylvania State University)H-Index: 21
Last. Daniel N. Klein (SBU: Stony Brook University)H-Index: 73
view all 7 authors...
Abstract Background The Research Domain Criteria (RDoC) constructs of Positive Valence Systems (PVS) and Negative Valence Systems (NVS) are presumed to manifest behaviorally through early-emerging temperamental negative affectivity (NA) and positive affectivity (PA). The late positive potential (LPP) is a physiological measure of attention towards both negative and positive emotional stimuli; however, its associations with behavioral aspects of PVS and NVS have yet to be examined. Methods In a c...
6 CitationsSource
#1Roman Kotov (SBU: Stony Brook University)H-Index: 38
#2Robert F. Krueger (UMN: University of Minnesota)H-Index: 93
Last. Mark Zimmerman (Brown University)H-Index: 68
view all 40 authors...
The reliability and validity of traditional taxonomies are limited by arbitrary boundaries between psychopathology and normality, often unclear boundaries between disorders, frequent disorder co-occurrence, heterogeneity within disorders, and diagnostic instability. These taxonomies went beyond evidence available on the structure of psychopathology and were shaped by a variety of other considerations, which may explain the aforementioned shortcomings. The Hierarchical Taxonomy Of Psychopathology...
311 CitationsSource
#1Brittany C. SpeedH-Index: 5
#2Brady D. NelsonH-Index: 19
Last. Greg HajcakH-Index: 66
view all 5 authors...
22 CitationsSource
#1Annmarie MacNamara (UIC: University of Illinois at Chicago)H-Index: 17
#2Roman Kotov (SBU: Stony Brook University)H-Index: 38
Last. Greg Hajcak (SBU: Stony Brook University)H-Index: 66
view all 3 authors...
The delineation of specific versus overlapping mechanisms in generalized anxiety disorder (GAD) and major depressive disorder (MDD) could shed light on the integrity of these diagnostic categories. For example, negative emotion generation is one mechanism that may be especially relevant to both disorders. Emotional processing abnormalities were examined among 97 outpatients with GAD or MDD and 25 healthy adults, using the late positive potential (LPP), an event-related potential that is larger f...
32 CitationsSource
This article describes the National Institute of Mental Health's Research Domain Criteria (RDoC) initiative. The description includes background, rationale, goals, and the way the initiative has been developed and organized. The central RDoC concepts are summarized and the current matrix of constructs that have been vetted by workshops of extramural scientists is depicted. A number of theoretical and methodological issues that can arise in connection with the nature of RDoC constructs are highli...
210 CitationsSource
#1Peter LangH-Index: 123
#2Lisa M. McTeague (Sewanee: The University of the South)H-Index: 18
Last. Margaret M. BradleyH-Index: 69
view all 3 authors...
Evidence is presented supporting a dimension of defensive reactivity that varies across the anxiety disorder spectrum and is defined by physiological responses during threat-imagery challenges that covary with objective measures of psychopathology. Previous imagery studies of anxiety disorders are reviewed, highlighting that, regardless of contemporary diagnostic convention, reliable psychophysiological patterns emerge for patients diagnosed with circumscribed fear compared to those diagnosed wi...
48 CitationsSource
#1Anna WeinbergH-Index: 27
#2Greg PerlmanH-Index: 13
Last. Greg HajcakH-Index: 66
view all 4 authors...
Abnormal patterns of attention to threat and reward have been proposed as potential mechanisms of dysfunction in anxiety and unipolar depressive disorders. However, few studies have simultaneously examined whether these patterns of attention are shared among disorders or distinguish between them. In the present study, we recorded the Late Positive Potential (LPP), an event-related potential and putative index of motivated attention, from 145 patients with anxiety and unipolar depressive disorder...
38 CitationsSource
#1Roman KotovH-Index: 38
1 CitationsSource
#1Stewart A. Shankman (UIC: University of Illinois at Chicago)H-Index: 24
#2Stephanie M. Gorka (UIC: University of Illinois at Chicago)H-Index: 16
Abstract The NIMH Research Domain Criteria (RDoC) initiative seeks to re-conceptualize psychopathology by identifying transdiagnostic constructs that reflect core mechanisms of psychopathology. Although the RDoC framework has been discussed in many prior papers, there are several methodological and conceptual points that have yet to be fully specified. For example, little discussion exists on the importance of distinguishing each construct's nomological network and linking it to risk for psychop...
25 CitationsSource
#1Brady D. Nelson (SBU: Stony Brook University)H-Index: 19
#2Greg Perlman (SBU: Stony Brook University)H-Index: 13
Last. Roman Kotov (SBU: Stony Brook University)H-Index: 38
view all 5 authors...
BACKGROUND: The late positive potential (LPP) is an event-related potential component that is sensitive to the motivational salience of stimuli. Children with a parental history of depression, an indicator of risk, have been found to exhibit an attenuated LPP to emotional stimuli. Research on depressive and anxiety disorders has organized these conditions into two empirical classes: distress and fear disorders. The present study examined whether parental history of distress and fear disorders wa...
38 CitationsSource
Cited By7
Newest
#1Wenhai ZhangH-Index: 3
Last. Hong LiH-Index: 27
view all 9 authors...
Source
#1Autumn Kujawa (Vandy: Vanderbilt University)H-Index: 21
#2Daniel N. Klein (SBU: Stony Brook University)H-Index: 73
Last. Anna Weinberg (McGill University)H-Index: 27
view all 4 authors...
Abstract Reduced activation of positive valence systems (PVS), including blunted neural and physiological responses to pleasant stimuli and rewards, has been shown to prospectively predict the development of psychopathology. Yet, little is known about how reduced PVS activation emerges across development or what implications it has for prevention. We review genetic, temperament, parenting, and naturalistic and laboratory stress research on neural measures of PVS and outline developmentally-infor...
Source
#1Greg Hajcak (FSU: Florida State University)H-Index: 66
#2Dan Foti (Purdue University)H-Index: 28
Event-related potential studies of emotional processing have focused on the late positive potential (LPP), a sustained positive deflection in the ERP that is increased for emotionally arousing stimuli. A prominent theory suggests that modulation of the LPP is a response to stimulus significance, defined in terms of the activation of appetitive and aversive motivational systems. The current review incorporates experimental studies showing that manipulations that alter the significance of stimuli ...
Source
#1Diana J. Whalen (WashU: Washington University in St. Louis)H-Index: 15
#2Kirsten E. Gilbert (WashU: Washington University in St. Louis)H-Index: 8
Last. Deanna M (WashU: Washington University in St. Louis)H-Index: 77
view all 7 authors...
Reductions in positive affect are a salient feature of preschool-onset major depressive disorder. Yet, little is known about the psychophysiological correlates of this blunted positive affect and whether reduced physiological responding to pleasant stimuli may differentiate depressed and healthy young children. 120 four-to-seven year old children with current depression and 63 psychiatrically healthy 4-to-7 year old children completed a simple picture-viewing task of pleasant and neutral picture...
1 CitationsSource
#1Vincent Rozalski (UNLV: University of Nevada, Las Vegas)H-Index: 5
#2Stephen D. Benning (UNLV: University of Nevada, Las Vegas)H-Index: 19
Abstract Personality is related to psychopathology and its higher-order structures, but there is little research regarding neurobiological associations of higher-order psychopathology factors. This study examined the factor structure of a wide range of psychopathology and its associations with both personality and emotional reactivity revealed through the late positive potential (LPP) in a sample of 275 undergraduates. A three-factor structure of psychopathology emerged comprising Internalizing ...
1 CitationsSource
#1Aislinn Sandre (McGill University)H-Index: 2
#2Rosemary C. Bagot (McGill University)H-Index: 7
Last. Anna Weinberg (McGill University)H-Index: 27
view all 3 authors...
Abstract Individual differences in neural response to appetitive and aversive stimuli may confer vulnerability to stress-related psychopathology, including depression and anxiety. However, the specificity of this association with symptoms of depression and anxiety within the context of real-world stress is not well understood. The present study examined whether neural responses to appetitive and aversive images, measured by the late positive potential (LPP), prospectively predict symptoms of dep...
1 CitationsSource
#1Annmarie MacNamara (A&M: Texas A&M University)H-Index: 17
#2T. Bryan Jackson (A&M: Texas A&M University)H-Index: 1
Last. K. Luan Phan (UIC: University of Illinois at Chicago)H-Index: 54
view all 5 authors...
Abstract Background Internalizing disorders such as anxiety may be characterized by an imbalance between bottom-up (stimulus-driven) and top-down (goal-directed) attention. The late positive potential (LPP) can be used to assess these processes when task-irrelevant negative and neutral pictures are presented within a working memory paradigm. Prior work using this paradigm has found that working memory load reduces the picture-elicited LPP across participants; however, anxious individuals showed ...
2 CitationsSource
#1Paige Ethridge (McGill University)H-Index: 2
#2Anna Weinberg (McGill University)H-Index: 27
Abstract Reward-related event-related potentials (ERPs) are often used to index individual differences that signal the presence or predict the onset of psychopathology. However, relatively little research has explored the psychometric properties of reward-related ERPs. Without understanding their psychometric properties, the value of using ERPs as biomarkers for psychopathology is limited. The present study, therefore, sought to establish the internal consistency reliability and convergent valid...
9 CitationsSource
#1Aislinn Sandre (McGill University)H-Index: 2
#2Paige Ethridge (McGill University)H-Index: 2
Last. Anna Weinberg (McGill University)H-Index: 27
view all 4 authors...
Childhood maltreatment increases lifetime vulnerability for psychopathology. One proposed mechanism for this association is that early maltreatment increases vigilance for and attention to subtle threat cues, persisting outside of the environment in which maltreatment occurs. To test this possibility, the present study examined neural responses to ambiguous and nonambiguous threatening facial expressions in a sample of 25 adults reporting a history of low-to-moderate levels of abuse in childhood...
1 CitationsSource
#1Molly A. Erickson (RU: Rutgers University)H-Index: 5
#2Emily S. Kappenman (SDSU: San Diego State University)H-Index: 21
Last. Steven J. Luck (UC Davis: University of California, Davis)H-Index: 80
view all 3 authors...
1 CitationsSource