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Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
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Papers 490
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#1Amy C. Janes (Harvard University)H-Index: 17
#2Nathan L. Krantz (McLean Hospital)
Last.Scott E. Lukas (Harvard University)H-Index: 49
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Abstract Background The insula has a well-established role in nicotine dependence and is a node of the salience network (SN), which integrates internal and external information to guide behavior. Recent findings reveal that internal and external processing occurs in the ventral and dorsal anterior insula (vAI/dAI), respectively. Whether vAI/dAI network connectivity differentially reflects internally-generated craving and externally-triggered smoking cue reactivity was tested. Methods Thirty-six ...
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Abstract Background Computational models show great promise in mapping latent decision-making processes onto dissociable neural substrates and clinical phenotypes. One prominent example in reinforcement learning (RL) is model-based planning, which specifically relates to transdiagnostic compulsivity. However, the reliability of computational model-derived measures like model-based planning is unclear. Establishing reliability is necessary to ensure such models measure stable, trait-like processe...
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Abstract Background Insights from neuroimaging-based biomarker research have not yet translated into clinical practice. This translational gap may stem from a focus on diagnostic classification, rather than on prediction of transdiagnostic psychiatric symptom severity. Currently, no transdiagnostic, multimodal predictive models of symptom severity that include neurobiological characteristics have emerged. Methods We built predictive models of 3 common symptoms in psychiatric disorders (dysregula...
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Abstract Background Deficient extinction learning has been suggested as an important mechanism involved in the etiology of posttraumatic stress disorder (PTSD). A key feature of PTSD, re-experiencing the trauma in form of intrusions, may be linked to deficient extinction learning. This link is investigated in a novel, fMRI-compatible fear conditioning procedure that uses trauma-films. Based on previous results, we expected deficient fear extinction indexed by exaggerated responding in anterior i...
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#1Manoj K. Doss (U of C: University of Chicago)
#2Jessica Weafer (U of C: University of Chicago)H-Index: 18
Last.Harriet de Wit (U of C: University of Chicago)H-Index: 68
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Abstract Background With the growing acceptance of cannabis, it is crucial to understand the drug’s effects on episodic memory accuracy and distortion. Here, we investigated the impact of Δ9-tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, on a context-based memory illusion. Methods In a double-blind, placebo-controlled, within-subjects design, healthy infrequent cannabis users (N = 24) memorized object pictures superimposed over scenes (e.g., grey cat on beach) after p...
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Abstract Background Childhood aggression has been linked to white matter abnormalities, but research has been inconsistent in both regions of alterations and directionality of the associations. We examined white matter microstructure correlates of aggression using a novel diffusion imaging analysis technique, fixel-based analysis, which leverages connectivity and crossing-fiber information to assess fiber bundle density. Method The sample included 70 children with aggressive behavior and 25 heal...
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#1Rebecca WallerH-Index: 17
#2Rebecca Waller (UPenn: University of Pennsylvania)H-Index: 2
Last.Raul GonzalezH-Index: 29
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Abstract Background Neurobiological differences linked to socioemotional and cognitive processing are well-documented in youth with disruptive behavior disorders (DBDs), especially youth with callous-unemotional (CU) traits. The current study expanded this literature by examining gray matter volume (GMV) differences among DBD youth with CU traits (DBDCU+), without CU traits (DBD-only), and typically developing (TD) youth. Methods Data were from the first full sample release of the Adolescent Bra...
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Psychology
Neuroscience
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Functional magnetic resonance imaging
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