A comparative study of disintegration actions of various disintegrants using Kohonen's self-organizing maps

To gain a better understanding of disintegration actions, 11 different disintegrants were tested. Model tablets were prepared with various preparation conditions, and their disintegration time and tensile strength were measured. The present study also investigated various physicochemical properties of the model tablets and disintegrant powders, including wetting time, water absorption ratio, particle size, morphological observation, swelling...