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Yoshihiro Hayashi
University of Toyama
Finite element methodOrganic chemistryChemistryMicrocrystalline celluloseChromatography
33Publications
7H-index
100Citations
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Publications 34
Newest
#1Takuya Oishi (University of Toyama)H-Index: 1
#2Yoshihiro Hayashi (University of Toyama)H-Index: 7
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 8 authors...
Abstract Our aim was to understand better the causal relationships between material attributes (MAs), process parameters (PPs), and critical quality attributes (CQAs) using an originally created large dataset and regularized linear regression models. In this study, we focused on the following three points: (1) creation of a dataset comprising several tablet production methods, (2) the influence of interaction terms of MAs and/or PPs, and (3) comparison of regularized linear regression models wit...
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#1Kotaro Okada (University of Toyama)H-Index: 1
#2Daijiro HiraiH-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 6 authors...
Source
#1Takahiro Tsuji (University of Toyama)H-Index: 1
#2Koji Mochizuki (Hoshi University)
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 7 authors...
Abstract The time–temperature superposition principle (TTSP) was applied to the destabilization kinetics of a pharmaceutical emulsion. The final goal of this study is to predict precisely the emulsion stability after long-term storage from the short-period accelerated test using TTSP. As the model emulsion, a cream preparation that is clinically used for the treatment of pruritus associated with chronic kidney disease was tested. After storage at high temperatures ranging from 30 to 45 °C for de...
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#1Yoshihiro Hayashi (University of Toyama)H-Index: 7
#2Yuki Marumo (University of Toyama)H-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
Abstract The purpose of this study was to explore the potential of a quantitative structure–property relationship (QSPR) model to predict tablet density. First, we calculated 3381 molecular descriptors for 81 active pharmaceutical ingredients (API). Second, we obtained data that were merged with a dataset including powder properties that we had constructed previously. Next, we prepared 81 types of tablet, each containing API, microcrystalline cellulose, and magnesium stearate using direct compre...
Source
#1Terushi Ito (University of Toyama)
#2Kotaro Okada (University of Toyama)H-Index: 1
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 8 authors...
Source
#1Kotaro Okada (University of Toyama)H-Index: 1
#2Daijiro HiraiH-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 6 authors...
Source
#1Kotaro Okada (University of Toyama)H-Index: 1
#2Daijiro HiraiH-Index: 2
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 6 authors...
Abstract The aim of this study was to demonstrate the usefulness of the time domain nuclear magnetic resonance (TD-NMR) method to characterize the crystalline state of active pharmaceutical ingredients (APIs) containing solid dosage forms. In this study, carbamazepine and indomethacin are used as models for poorly water-soluble APIs. First, we measured the T1 and T2 relaxation behavior of crystalline and amorphous APIs. From the results, we were able to confirm that the T1 relaxation time measur...
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#1Masamitsu Yokokawa (Hoshi University)H-Index: 1
#2Haruna Setoyama (Hoshi University)
Last. Yasuko Obata (Hoshi University)H-Index: 20
view all 7 authors...
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#1Terushi Ito (University of Toyama)
#2Chihiro Kida (Hoshi University)H-Index: 3
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
The purpose of the present study is to demonstrate the applicability of magnetic resonance imaging, especially T2 relaxation time mapping, for nondestructive monitoring of the dispersion state of nanoparticles (NPs) in concentrated suspensions. TiO2 15-nm-diameter NPs, for use in sunscreen lotion products, were examined as a test NP. First, this study investigated whether T2 is sensitive to the NP concentration. In experiments with pulsed nuclear magnetic resonance on TiO2 NP suspensions with di...
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#1Siriporn Phutthatiraphap (University of Toyama)H-Index: 1
#2Yoshihiro Hayashi (University of Toyama)H-Index: 7
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 9 authors...
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