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Correction of a pathogenic gene mutation in human embryos

Published on Aug 1, 2017in Nature43.07
· DOI :10.1038/nature23305
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(OHSU: Oregon Health & Science University)
+ 28 AuthorsShoukhrat Mitalipov36
Estimated H-index: 36
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Abstract
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
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  • Citations (328)
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