Nuria Marti-Gutierrez
Oregon Health & Science University
Publications 3
#1Hong MaH-Index: 27
Last.Shoukhrat MitalipovH-Index: 36
view all 30 authors...
#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Yeonmi Lee (Oregon National Primate Research Center)H-Index: 6
Last.Shoukhrat Mitalipov (Oregon National Primate Research Center)H-Index: 36
view all 15 authors...
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multiple organs and tissues in young and old (2–34 months) wild type (wt) mice was investigated by whole genome sequencing. Remarkably, no acquired somatic mutations were detected in tested tissues. Howeve...
1 CitationsSource
#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Nuria Marti-Gutierrez (OHSU: Oregon Health & Science University)H-Index: 1
Last.Shoukhrat MitalipovH-Index: 36
view all 31 authors...
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
328 CitationsSource