Shoukhrat Mitalipov
Oregon Health & Science University
128Publications
36H-index
4,992Citations
Publications 128
Newest
Published on Feb 1, 2019in JACC: Basic to Translational Science
David German1
Estimated H-index: 1
(Oregon Health & Science University),
Shoukhrat Mitalipov36
Estimated H-index: 36
(Oregon Health & Science University)
+ 1 AuthorsS. Kaul84
Estimated H-index: 84
(Oregon Health & Science University)
Summary A variety of genetic cardiovascular diseases may one day be curable using gene editing technology. Germline genome editing and correction promises to permanently remove monogenic cardiovascular disorders from the offspring and subsequent generations of affected families. Although technically feasible and likely to be ready for implementation in humans in the near future, this approach remains ethically controversial. Although currently beset by several technical challenges, and not yet p...
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Published on Mar 1, 2019in Nature 41.58
Eunju Kang13
Estimated H-index: 13
(Oregon National Primate Research Center),
Jun Wu28
Estimated H-index: 28
(Salk Institute for Biological Studies)
+ 27 AuthorsYeonmi Lee6
Estimated H-index: 6
(Oregon National Primate Research Center)
Change history In this Letter, there are several errors regarding the assignments of mtDNA haplotypes for a subset of egg donors from our study. These errors have not been corrected online.
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Published on May 1, 2018in European Heart Journal 23.43
S. Kaul84
Estimated H-index: 84
,
Stephen Heitner6
Estimated H-index: 6
(Oregon Health & Science University),
Shoukhrat Mitalipov36
Estimated H-index: 36
(Oregon Health & Science University)
1 Citations Source Cite
Published on Mar 8, 2018in Investigative Ophthalmology & Visual Science 3.39
Trevor J. McGill40
Estimated H-index: 40
(Oregon National Primate Research Center),
Jonathan Stoddard3
Estimated H-index: 3
(Oregon National Primate Research Center)
+ 6 AuthorsMartha Neuringer36
Estimated H-index: 36
(Oregon National Primate Research Center)
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Published on Jul 24, 2018in PLOS ONE 2.77
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Yeonmi Lee6
Estimated H-index: 6
(Oregon National Primate Research Center)
+ 12 AuthorsHayley Darby1
Estimated H-index: 1
(Oregon National Primate Research Center)
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multiple organs and tissues in young and old (2–34 months) wild type (wt) mice was investigated by whole genome sequencing. Remarkably, no acquired somatic mutations were detected in tested tissues. Howeve...
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Published on Nov 1, 2018in Fertility and Sterility 4.80
Jing Xu13
Estimated H-index: 13
(Oregon National Primate Research Center),
Maralee S. Lawson9
Estimated H-index: 9
(Oregon National Primate Research Center)
+ 2 AuthorsFuhua Xu1
Estimated H-index: 1
(Oregon Health & Science University)
Objective To study whether follicular growth and oocyte maturation can be improved by antimullerian hormone (AMH) modulation at specific stages of follicular development. Design Primary and secondary follicles were cultured in a matrix-free system and were assigned to the control group and the group with AMH supplementation during the preantral stage and neutralizing AMH antibody addition during the antral stage. Setting National primate research center. Animal(s) Adult, female rhesus macaques (...
1 Citations Source Cite
Published on Aug 1, 2017in The EMBO Journal 10.56
Don P. Wolf43
Estimated H-index: 43
(Oregon Health & Science University),
Tomonari Hayama7
Estimated H-index: 7
(Oregon Health & Science University),
Shoukhrat Mitalipov36
Estimated H-index: 36
(Oregon Health & Science University)
Mitochondria, the ubiquitous power packs in nearly every eukaryotic cell, contain their own DNA, known as mtDNA, which is inherited exclusively from the mother. The number of mitochondrial genomes varies depending on the cell9s energy needs. The mature oocyte contains the highest number of mitochondria of any cell type, although there is little if any mtDNA replication after fertilization until the embryo implants. This has potential repercussions for mitochondrial replacement therapy (MRT; see ...
6 Citations Source Cite
Published on Aug 1, 2017in Nature 41.58
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(Oregon Health & Science University)
Genome editing could be applied to correct disease-causing mutations in human embryos, but concerns about efficacy and safety are paramount. Shoukhrat Mitalipov and colleagues use CRISPRCas9 to correct a heritable cardiomyopathy mutation in human embryos. By optimizing the experimental conditions, the authors show very reduced mosaicism, and report that for this heterozygous mutation, CRISPRCas9-induced breaks seem to be preferentially repaired using the wild-type allele as a template in human e...
238 Citations Source Cite
Published on Jan 1, 2017in Stem Cells 5.59
Don P. Wolf43
Estimated H-index: 43
,
Robert Morey9
Estimated H-index: 9
+ 4 AuthorsShoukhrat Mitalipov36
Estimated H-index: 36
Embryonic stem cells (ESC) hold promise for the treatment of human medical conditions but are allogeneic. Here, we consider the differences between autologous pluripotent stem cells produced by nuclear transfer (NT-ESCs) and transcription factor-mediated, induced pluripotent stem cells (iPSCs) that impact the desirability of each of these cell types for clinical use. The derivation of NT-ESCs is more cumbersome and requires donor oocytes; however, the use of oocyte cytoplasm as the source of rep...
9 Citations Source Cite
Ming-Tao Zhao11
Estimated H-index: 11
(Stanford University),
Haodong Chen10
Estimated H-index: 10
(Stanford University)
+ 15 AuthorsYoungkyun Kim8
Estimated H-index: 8
(Stanford University)
Abstract Patient-specific pluripotent stem cells (PSCs) can be generated via nuclear reprogramming by transcription factors (i.e., induced pluripotent stem cells, iPSCs) or by somatic cell nuclear transfer (SCNT). However, abnormalities and preclinical application of differentiated cells generated by different reprogramming mechanisms have yet to be evaluated. Here we investigated the molecular and functional features, and drug response of cardiomyocytes (PSC-CMs) and endothelial cells (PSC-ECs)...
11 Citations Source Cite
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