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Shoukhrat Mitalipov
Shandong University
132Publications
36H-index
5,505Citations
Publications 126
Newest
#1Meiling Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Changyang Zhou (CAS: Chinese Academy of Sciences)H-Index: 5
Last.Hui Yang (CAS: Chinese Academy of Sciences)H-Index: 19
view all 17 authors...
Base editing installs a precise nucleotide change in specific gene loci without causing a double-strand break. Its efficiency in human embryos is generally low, limiting its utility in functional genetic studies. Here, we report that injecting base editors into human cleaving two-cell and four-cell embryos results in much higher (up to 13-fold) homozygotic nucleotide substitution efficiency as opposed to MII oocytes or zygotes. Furthermore, as a proof-of-principle study, a point mutation can be ...
Source
#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Tomonari Hayama (Oregon National Primate Research Center)H-Index: 8
Last.Shoukhrat Mitalipov (Oregon National Primate Research Center)H-Index: 36
view all 21 authors...
Source
#1Eunju Kang (UOU: University of Ulsan)
#2Amy Koski (OHSU: Oregon Health & Science University)H-Index: 5
Last.Shoukhrat Mitalipov (OHSU: Oregon Health & Science University)H-Index: 36
view all 5 authors...
Source
#1Don P. Wolf (OHSU: Oregon Health & Science University)H-Index: 42
#2Paul A. Mitalipov (OHSU: Oregon Health & Science University)H-Index: 1
Last.Shoukhrat Mitalipov (OHSU: Oregon Health & Science University)H-Index: 36
view all 3 authors...
Monogenic disorders occur at a high frequency in human populations and are commonly inherited through the germline. Unfortunately, once the mutation has been transmitted to a child, only limited treatment options are available in most cases. However, means of correcting disease-causing nuclear and mitochondrial DNA mutations in gametes or preimplantation embryos have now been developed and are commonly referred to as germline gene therapy (GGT). We will discuss these novel strategies and provide...
1 CitationsSource
#1Eunju Kang (Oregon National Primate Research Center)H-Index: 13
#2Jun Wu (Salk Institute for Biological Studies)H-Index: 29
Last.Shoukhrat MitalipovH-Index: 36
view all 30 authors...
Change history In this Letter, there are several errors regarding the assignments of mtDNA haplotypes for a subset of egg donors from our study. These errors have not been corrected online.
2 CitationsSource
#1David German (Cardiovascular Institute of the South)H-Index: 1
#2Shoukhrat Mitalipov (Cardiovascular Institute of the South)H-Index: 36
Last.Sanjiv Kaul (Cardiovascular Institute of the South)H-Index: 82
view all 4 authors...
Summary A variety of genetic cardiovascular diseases may one day be curable using gene editing technology. Germline genome editing and correction promises to permanently remove monogenic cardiovascular disorders from the offspring and subsequent generations of affected families. Although technically feasible and likely to be ready for implementation in humans in the near future, this approach remains ethically controversial. Although currently beset by several technical challenges, and not yet p...
Source
#1Jing Xu (Oregon National Primate Research Center)H-Index: 13
#2Maralee S. Lawson (Oregon National Primate Research Center)H-Index: 8
Last.Fuhua Xu (OHSU: Oregon Health & Science University)H-Index: 2
view all 5 authors...
Objective To study whether follicular growth and oocyte maturation can be improved by antimullerian hormone (AMH) modulation at specific stages of follicular development. Design Primary and secondary follicles were cultured in a matrix-free system and were assigned to the control group and the group with AMH supplementation during the preantral stage and neutralizing AMH antibody addition during the antral stage. Setting National primate research center. Animal(s) Adult, female rhesus macaques (...
1 CitationsSource
#1Hong MaH-Index: 27
Last.Shoukhrat MitalipovH-Index: 36
view all 30 authors...
Source
#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Yeonmi Lee (Oregon National Primate Research Center)H-Index: 6
Last.Shoukhrat Mitalipov (Oregon National Primate Research Center)H-Index: 36
view all 15 authors...
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multiple organs and tissues in young and old (2–34 months) wild type (wt) mice was investigated by whole genome sequencing. Remarkably, no acquired somatic mutations were detected in tested tissues. Howeve...
1 CitationsSource
#1Sanjiv KaulH-Index: 82
#2Stephen Heitner (OHSU: Oregon Health & Science University)H-Index: 7
Last.Shoukhrat Mitalipov (OHSU: Oregon Health & Science University)H-Index: 36
view all 3 authors...
1 CitationsSource
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