Match!

Polyphenols of virgin coconut oil prevent pro-oxidant mediated cell death

Published on Jul 24, 2017in Toxicology Mechanisms and Methods2.28
· DOI :10.1080/15376516.2017.1320458
Soorya Parathodi Illam4
Estimated H-index: 4
,
Arunaksharan Narayanankutty6
Estimated H-index: 6
,
Achuthan C. Raghavamenon5
Estimated H-index: 5
Cite
Abstract
AbstractVirgin coconut oil (VCO), extracted from the fresh coconut kernel, is a food supplement enriched with medium chain saturated fatty acids and polyphenolic antioxidants. It is reported to have several health benefits including lipid lowering, antioxidant and anti-inflammatory activities. The pharmacological benefits of VCO have been attributed to its polyphenol content (VCOP), the mechanistic basis of which is less explored. Liquid chromatography/mass spectroscopy (LC/MS) analysis of VCOP documented the presence of gallic acid, ferulic acid (FA), quercetin, methyl catechin, dihydrokaempferol and myricetin glycoside. Pre-treatment of VCOP at different concentrations (25–100 μg/mL) significantly reduced the H2O2 and 2,2′-azobis (2-amidinopropane) dihydrochloride (AAPH) induced cell death in HCT-15 cells. Giving further insight to its mechanistic basis, oxidative stress induced alterations in glutathione (GSH) levels and activities of GR (Glutathione–Reductase), GPx (Glutathione–Peroxidase), GST (Gluta...
  • References (52)
  • Citations (12)
Cite
References52
Newest
#1A. D. Naveen Kumar (GITAM: Gandhi Institute of Technology and Management)H-Index: 1
#2Ganesh Babu Bevara (GITAM: Gandhi Institute of Technology and Management)H-Index: 1
Last.Rama Rao Malla (GITAM: Gandhi Institute of Technology and Management)H-Index: 12
view all 5 authors...
#1Stefania Catino (CUA: The Catholic University of America)H-Index: 2
#2Fabiola Paciello (CUA: The Catholic University of America)H-Index: 1
Last.Cesare Mancuso (CUA: The Catholic University of America)H-Index: 45
view all 8 authors...
#1Qianying Zhang (WHU: Wuhan University)H-Index: 2
#2Zhike Li (WHU: Wuhan University)H-Index: 6
Last.Hong Ding (WHU: Wuhan University)H-Index: 10
view all 8 authors...
Cited By12
Newest
#1Vinayak Narayanankutty (Government Medical College, Thiruvananthapuram)H-Index: 1
#2Arunaksharan Narayanankutty (St. Joseph's College, Devagiri)H-Index: 1
Last.Anusree NairH-Index: 1
view all 3 authors...
#1Ali Osman (Zagazig University)H-Index: 9
View next paperVirgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats