Pediatric Irritability: A Systems Neuroscience Approach

Irritability in youth is a common clinical problem that may result from aberrant responses to frustration and/or aberrant approach responses to threat. Irritability and anxiety are associated cross-sectionally, longitudinally, and genetically. These associations suggest that disequilibrium in threat response circuitry is important in the pathophysiology of irritability. Studies using simple or complex social stimuli find hyper-reactivity to...