Oral Biodisposition Study of Ritodrine after Its Buccal Administration in Rats

In the previous study, buccal absorption of ritodrine (RD) hydrochloride was reported in vivo. As a result, buccal dosing of RD solution was found to be useful for the maintenance of effective plasma concentration. However, in order to find out the dosing schedule more clearly, it is important to clarify the in vivo drug behavior.The biodistributions of RD in oral cavity and buccal mucosal were investigated in order to understand the in vivo...