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Osamu Sakata
Hoshi University
ChemistryBuccal administrationIn vivoRitodrineChromatography
13Publications
6H-index
139Citations
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Publications 13
Newest
#1Koichi Saito (Hoshi University)H-Index: 34
#2Yukino Oshiro (Hoshi University)
Last. Rie Ito (Hoshi University)H-Index: 33
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#1Hiraku Onishi (Hoshi University)H-Index: 24
#2Osamu Sakata (Hoshi University)H-Index: 6
Abstract Etilefrine hydrochloride (ET-HCl) is used in the treatment of hypotension. Dosage forms of orally administered tablets and parenteral injections are clinically available, but exhibit unfavorable characteristics, including cardiac toxicity, headaches, and damage at the injection site for the parenteral dosage form, and initially high plasma levels, fast elimination, and first-pass effects for its oral administration. Therefore, the buccal application of ET-HCl was herein investigated as ...
Source
#1Hiraku OnishiH-Index: 24
#2Kei YumotoH-Index: 2
Last. Osamu SakataH-Index: 6
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Background: In the previous study, buccal absorption of ritodrine (RD) hydrochloride was reported in vivo. As a result, buccal dosing of RD solution was found to be useful for the maintenance of effective plasma concentration. However, in order to find out the dosing schedule more clearly, it is important to clarify the in vivo drug behavior. Objective: The biodistributions of RD in oral cavity and buccal mucosal were investigated in order to understand the in vivo drug behavior after the buccal...
2 CitationsSource
#1Hiraku Onishi (Hoshi University)H-Index: 24
#2Osamu Sakata (Hoshi University)H-Index: 6
Last. Kei Yumoto (Hoshi University)H-Index: 2
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1 CitationsSource
#1Hiraku Onishi (Hoshi University)H-Index: 24
#2Kei Yumoto (Hoshi University)H-Index: 2
Last. Osamu Sakata (Hoshi University)H-Index: 6
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Abstract Ritodrine hydrochloride (RD-HCl) tablets containing alginate (AL) and lactose (LC) with or without microcrystalline cellulose (MC) as excipients were produced as a buccal dosage form. The RD-HCl (2 mg) tablets with AL/LC but no MC swelled and dissolved gradually in the in vitro dissolution test. The tablet showing the fastest dissolution and highest drug release rate, called Tablet A1, was selected as a tablet to show rapid and prolonged absorption. However, in the in vivo buccal absorp...
7 CitationsSource
#1Osamu Sakata (Hoshi University)H-Index: 6
#2Hiraku Onishi (Hoshi University)H-Index: 24
Background: Although ritodrine (RD)-hydrochloride (HCl), named RD-HCl, is widely used in the treatment of premature labor by intravenous prolonged infusion or frequent oral dosing of tablets, those administrations often lower patients’ quality of life (QOL) or cause undesirable side effects, such as tachycardia; therefore, in this study, the potential usefulness of buccal administration as a novel administration method was examined in vivo.Method: First, the HPLC method was assessed for the dete...
3 CitationsSource
#1Osamu Sakata (Hoshi University)H-Index: 6
#2Yoshiharu Machida (Hoshi University)H-Index: 38
Last. Hiraku Onishi (Hoshi University)H-Index: 14
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Background: In order to obtain an alternative to the intravenous (i.v.) dosage form of clonazepam (CZ), an oral droplet formulation of CZ was developed previously; however, the droplet was physically unstable. Therefore, in the present study, it was attempted to develop an easily-handled dosage form, which was more physically stable and allowed rapid drug absorption from oral mucosa. Method: A semi-solid dosage form, composed of polyethylene glycol 1500 (PEG), CZ, and oleic acid (OA) at 37/1/2 (...
4 CitationsSource
#1Hiraku Onishi (Hoshi University)H-Index: 24
#2Kennichi Koyama (Hoshi University)H-Index: 1
Last. Yoshiharu Machida (Hoshi University)H-Index: 38
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Background: Although lactoferrin (LF) possesses useful functions such as antitumor, antiviral, and anti-inflammatory acitivities, it is subject to gastric digestion, resulting in the reduction of efficacy. Therefore, it is important to develop a system delivering LF efficiently to intestinal mucosa or gut-associated lymphoid tissue. Method: Chitosan/alginate/calcium complex microparticles containing LF at a high loading were prepared using alginate, LF, and calcium chloride at the ratio of 6:3:8...
20 CitationsSource
#1Osamu Sakata (Hoshi University)H-Index: 6
#2Hiraku Onishi (Hoshi University)H-Index: 24
Last. Yoshiharu MachidaH-Index: 38
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A semisolid dosage form of clonazepam (CZP), administered to the oral cavity between the lower gum and bottom lip with small volume of saline, was developed to obtain the stable dosage which can replace the injection dosage form. Semisolid dosage forms were prepared using a mixture of CZP/(polyethylene glycol 1500 (PEG))/(oleic acid (OA)) at the ratios of 1/39/0, 1/37/2 and 2/36/2 (w/w), named CZP1-PEG, CZP1-PEG-OA and CZP2-PEG-OA, respectively, and were evaluated in vitro and in vivo. No crysta...
1 CitationsSource
#1Ken-ichi Koyama (Memorial Hospital of South Bend)H-Index: 3
#2Hiraku Onishi (Hoshi University)H-Index: 24
Last. Yoshiharu Machida (Hoshi University)H-Index: 38
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An attempt was made to prepare FITC-labeled-lactoferrin (LF-FTC)-loaded microparticles, durable under gastrointestinal conditions, first by the combination of alginate/calcium complexation and emulsification-evaporation and next by treatment with chitosan solution. The obtained microparticles were examined for particle characteristics, in vitro release profiles and physical stability in solutions of pH 1.2 and 6.8. The obtained chitosan-coated alginate/calcium complex microparticles (Ch/Al/Ca-MP...
9 CitationsSource
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