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Current Drug Delivery
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#1Jalpa Patel (Government Pharmacy College, Bangalore)
#2Dhaval Mori (Government Pharmacy College, Bangalore)H-Index: 1
BACKGROUND: Developing a new excipient and obtaining its market approval is an expensive, timeconsuming and complex process. Compared to that the co-processing of already approved excipients has emerged as a more attractive option for bringing better characteristic excipients to the market. The application of Design of Experiments (DoE) approach for developing co-processed excipient can make the entire process cost-effective and rapid. OBJECTIVE: The aim of the present investigation was to demon...
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#1Ozgur Esim (UHSA: University of Health Sciences Antigua)H-Index: 1
#2Ayhan Savaser (UHSA: University of Health Sciences Antigua)H-Index: 2
Last. Yalcin Ozkan (UHSA: University of Health Sciences Antigua)H-Index: 2
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Migraine is a chronic, painful, neurological disorder that affects approximately 15% of the population worldwide. It is a form of neurovascular headache: a disorder in which neural events result in the dilation of blood vessels that, in turn, results in pain and further nerve activation. The pathogenesis of migraine was not completely understood but it is thought that both central and peripheral stimulations can play a role in migraine. Experimental pharmacological evidence suggests that some dr...
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BACKGROUND: The scope of nanotechnology has been extended to almost every spheres of our daily life. As a result of this, nanocarriers like carbon nanotubes (CNTs) are gaining a considerable amount of interest for the use in various therapeutical and diagnostical applications. OBJECTIVE: The objective of the current article is to review various important features of CNTs that make these as the efficient carriers for anticancer drug delivery in the cancer therapeutics. METHODS: In this review art...
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#1Shweta Rajawat (NIT-B: Maulana Azad National Institute of Technology)H-Index: 2
#2M.M. Malik (NIT-B: Maulana Azad National Institute of Technology)H-Index: 3
BACKGROUND: Amongst various cancer diseases, breast cancer is frequently diagnosed malignancy in women. Existing treatments are inadequate, painful and toxic. New ways of treatments need to be explored. METHODS: The present work proposes preparation and targeted delivery of a formulation, F-1, for MCF-7 breast cancer treatment. The formulation, colloidal silver (0.76 ppm), was prepared by electrolytic deposition technique and multi surface coatings. Black tea extract (2.25%v/v) was used as cappi...
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#1Panagiotis Theodosis-Nobelos (RMIT: RMIT University)H-Index: 4
#2Despina Charalambous (RMIT: RMIT University)
Last. Maria RikkouKalourkoti (RMIT: RMIT University)
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Polymer-drug conjugates are polymers with drug molecules chemically attached to polymer side chains through a weak covalent bond (degradable bond) or a dynamic covalent bond. These systems are known as prodrugs in the inactive form of the drug passing into the blood circulation system. When the prodrug reaches to the target organ, tissue or cell, the drug is activated by cleavage of the bond between the drug and polymer under certain conditions existing in the target organ. The advantages of pol...
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#1Claudia OrtegaH-Index: 4
#2Laura S. FavierH-Index: 6
Last. Diego A. Cifuente (CONICET: National Scientific and Technical Research Council)H-Index: 6
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BACKGROUND: In many countries, the hypertension in the pediatric population is considered an important risk of mortality and morbidity. In this sense, it is important to design and develop new pharmaceutical forms for pediatric patients with hypertension. The development of orodispersible mini-tablets (ODMTs) for paediatric use has gained importance within recent years the WHO authorities set up regulations for developing suitable and palatable dosage forms for paediatric patients. OBJECTIVE: Th...
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#1Philip Penketh (Westport Innovations)
#2Hugh S. WilliamsonH-Index: 1
Last. Krishnamurthy Shyam (Yale University)H-Index: 21
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Hypoxic tumor cell sub-populations are highly resistant to radiotherapy and their presence frequently causes disease recurrence and death. Here we describe the physicochemical properties required to develop superior tumor targeted hypoxia-activated modular prodrugs that liberate extremely short-lived bis(sulfonyl)hydrazines (BSHs) as reactive cytotoxins, thereby precisely focusing cytotoxic stress on these radio-resistant hypoxic sub-populations. Utilizing the strategy described new agents will ...
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Last. Renat R. Letfullin (RHIT: Rose-Hulman Institute of Technology)H-Index: 10
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BACKGROUND: Ophthalmology applies many different ways of delivering effective drugs to eye tissue for the prevention and treatment of diseases of various etiologies. The vast majority of ophthalmologists use traditional instillation of drugs in the period of eye disease. However, this method has a number of drawbacks, in particular, when instillation of drip forms of drugs, up to 80% of the drug is lost due to withdrawal of its tear fluid and rapid absorption by the mucous membrane of the eyes, ...
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#1David S. Jones ('QUB': Queen's University Belfast)H-Index: 43
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#1Anisha A D'souza (IITB: Indian Institute of Technology Bombay)H-Index: 1
#2Ranjita ShegokarH-Index: 18
In recent years, SLNs and NLCs are among the popular drug delivery systems studied for delivery of lipophilic drugs. Both systems have demonstrated several beneficial properties as an ideal drug-carrier, optimal drug-loading and good long-term stability. NLCs are getting popular due to their stability advantages and possibility to load various oil components either as an active or as a matrix. This review screens types of oils used till date in combination with solid lipid to form NLCs. These oi...
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